I have been diagnosed now for almost a year-although I have been ill for over 7 years-previously told it was 'just Fibromyalgia'-had steroids first of all-thought they were magic (so naive) then started on Methotrexate in Feb-gradually taking it up to 17.5mg, and lowered steroids, had stopped taking them orally by June-July, but had to have an injection mid August, as was feeling so shattered, and still had pain (but not as bad as before any treatment). After my latest Rheumy check up, was told to lower the Metho to 12.5 as my liver reading were high (also had a lot of hair loss),I asked him about Plaqunil and he was surprised that he had not put me on it already-so gave me some to try. Having read the leaflet, I thought they were going to take a while to work-but I felt better in days!! (I have felt nauseous and had a bit of IBS-think that is cause chemist gave me Quinoric not Plauinil) but other than that I feel very good-the exhaustion has really lifted, also the brain fog-and I just feel so much more agile-can even bend down!! And in the mornings I am so much brighter-is this just the tablets working already?