Hi All, I was diagnosed with sle in february & started on plaquenil, prednisone & tramadol for knee pain. When I last saw my rhuemy he said I have arthritis too & need to go on either methotrexate or azathioprine as plaquenil alone isn't working. Researched both & don't want to go on either. I would greatly appreciate any advice from anyone who has been on these drugs & who they affected/helped you. Many thanks in advance, Sezzie.