Can antibiotic eye drops affect your INR?

[travelnut]

I managed to get corneal ulcers in both eyes a couple of weeks ago. The eye doctor thought it was due to wearing contact lenses and having very dry eyes. I was prescribed antibiotic eye drops for 7 days - exocin (ofloxacin). Took my INR yesterday and in a week it had gone from an in range 3.8 (my range is 3.5-4.0) and had rocketed to 8.0!! I can't think of anything I have changed aside from the eye problem and using the eye drops. I did ask the eye doctor whether it would affect my INR and he said no as they were drops. I just wondered whether anyone else has found that eye drops can alter INR.

[Hidden]

Yes. Exocin will increase warfarin effect.

[travelnut in reply to Hidden]

Thanks Jim. It is the only thing I could think of that could have caused such a dramatic increase in my INR in a week but it didn't say anything about an interaction with warfarin on the package information insert.

[Hidden]

Virtually all medication will effect how well warfarin works.

[travelnut]

Thanks Lyn. I thought it must be the eye drops but after having antibiotics previously that haven't seemed to influence my INR and the Dr telling me the drops wouldn't affect my INR I was really surprised when my INR zoomed up by 4.2 in one week. I willl be testing more frequently this week now!!

I think you may be right about the other things going on as I have been extremely tired the last few days and have needed a couple of hours sleep each afternoon and I am still tired in the evenings.

[Hidden]

Hope the INR normalizes soon and stays in therapeutic range for you with little side effects.

How are the eyes? I know I had the corneal ulceration back in April and I don't use contacts.... They said it can be common in Autoimmune illness. I was seen at Aldenbrokes eye clinic.