New paper below [1].
In 1995, Edward Giovannucci was responsible for triggering the PCa lycopene craze.
"Of 46 vegetables and fruits or related products, four were significantly associated with lower prostate cancer risk; of the four--tomato sauce, tomatoes, and pizza, but not strawberries--were primary sources of lycopene."
Suddenly, pizza was a health food?
I often wondered about the lack of interest in fisetin (from strawberries). By ten years later, shortly after I was diagnosed. no product had emerged.
PCa studies began appearing in 2006, with 4 appearing in 2015.
The product I was waiting for did emerge: Novusetin, from Rhus succedanea (stem), but the PCa world yawned.
It turned out that fisetin was waiting for Life Extension to jump start the senolytics craze. Lots of competing fisetin products now.
But rutin? [3].
"Rutin, a phytochemical constituent found in a number of plants, showed remarkable capacity in targeting senescent cells by dampening expression of the full spectrum SASP."
{"Senescent cells develop the pro-inflammatory senescence-associated secretory phenotype (SASP), which significantly contributes to organismal aging and age-related disorders."}
"Further analysis indicated that rutin restrains the acute stress-associated phenotype (ASAP) by specifically interfering with the interactions of ATM with HIF1α, a master regulator of cellular and systemic homeostasis activated during senescence, and of ATM with TRAF6, part of a key signaling axis supporting the ASAP development toward the SASP."
"Conditioned media produced by senescent stromal cells enhanced the malignant phenotypes of prostate cancer cells, including in vitro proliferation, migration, invasion, and more importantly, chemoresistance, while rutin remarkably downregulated these gain-of-functions."
"remarkable capacity", "remarkably downregulated" - unusual language in PubMed papers. I have to get some [4].
-Patrick
[1] pubmed.ncbi.nlm.nih.gov/374...
[2] pubmed.ncbi.nlm.nih.gov/747...
