Fibromyalgia Action UK
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Just thinking (sort of) with all these tablets I'm taking for various illnesses - has anyone else ever wondered - How do they know which part of the body they are going to? In a lot of pain today n it also would have been my brothers birthday which sadly he has passed away - feeling a bit low but so glad I have everyone on here xxxx didn't know if anyone else thinks that lol xxxx lotsa fluffy hugs to all xx Mystique xxxx

4 Replies

Hi, so sorry at the loss of your brother, I thought the very same thing about my meds as I have been having problems finding meds for pain that didn't make me worse .. So am trying osteopathy and just my night meds which I know work.

Take care xxx


So sorry to hear about your brother Mystique, I'm sending you my condolences.

Regarding the meds' question, I have often wondered the same about my meds. If you have a toothache and take a painkiller it helps your sore gums and takes the pain away for a while as it calms the pain receptors in our bodies. Our meds work in a similar way -

Drugs generally work by interacting with receptors on the surface of cells or enzymes (which regulate the rate of chemical reactions) within cells. Receptor and enzyme molecules have a specific three-dimensional structure which allows only substances that fit precisely to attach to it. This is often referred to as a lock and key model.

Most drugs work because by binding to the target receptor site, they can either block the physiological function of the protein, or mimics it's effect. If a drug causes the protein receptor to respond in the same way as the naturally occurring substance, then the drug is referred to as an agonist. Examples of agonists are morphine, nicotine, phenylephrine, and isoproterenol. Antagonists are drugs that interact selectively with receptors but do not lead to an observed effect. Instead they reduce the action of an agonist at the receptor site involved. Receptor antagonists can be classified as reversible or irreversible. Reversible antagonists readily dissociate from their receptor. Irreversible antagonists form a stable chemical bond with their receptor (eg, in alkylation). Examples of antagonist drugs are: beta-blockers, such as propranolol.

Instead of receptors, some drugs target enzymes, which regulate the rate of chemical reactions. Drugs that target enzymes are classified as inhibitors or activators (inducers). Examples of drugs that target enzymes are: aspirin, cox-2 inhibitors and hiv protease inhibitors.

Nonsteroidal anti-inflammatory drugs work by interfering with the cyclooxygenase pathway. The normal process begins with arachidonic acid, a dietary unsaturated fatty acid obtained from animal fats. This acid is converted by the enzyme cyclooxygenase to synthesize different prostaglandins. The prostaglandins go on to stimulate many other regulatory functions and reactionary responses in the body including: inflammation and increased sensitivity to pain . Aspirin and other NSAID's work by inhibiting this pathway.

A bit mind boggling but fascinating info! :) :)


Thankyou all - paradise I agree its strange I have to have a soak every night to ease the pain a little - it does help wish there was some magic bubblebath or something that could distroy all of our pains etc lol n Libbydee thankyou so much will have to keep reading it over!! as I sort of know what you mean but mr fibrofog has taken over lol - n thankyou also to Madhelen I really appreciate it whenever anyone replies etc n I love reading all about you this site has really given me a boost - I cannot say how much as I couldn't put it into words - but my love n hugs goes out to you all xxxx


My pleasure Mystique, happy to help, take care! :) :D


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