I know everyone is different but I am only on Paroxetine (Seroxat) at the moment. But when I was diagnosed with fibro the rheumo told me that Amitryptiline helps a lot of people with fibro and can be taken with Paroxetine. Not being one to take any more pills than I have to, I have never taken Amitryptiline but as the Paroxetine has added a lot of weight I thought maybe Amitryptiline would be better, so mentioned to my GP and she prescribed Amitryptiline to take as well as Paroxetine. She wasn't sure if I would lose weight but she said it would help with my migraines and sleep problems. However, needless to say I've not taken it yet. I read the list of side-effects (always fatal!) and haven't taken any. I don't want to add on any more weight (I want to lose it) and I don't want any scary side-effects.