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Fibromyalgia Action UK
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I am thinking of taking a natural product calls 5-htp which is a seratonin enhancer, however it does say it may interact with amitriptiline ( I am on 50 mg at night) I just wondered if anyone else takes/ or has tried this and how things are with taking it with amityptiline, I realise we are not all the same but just interested in feedback from others, cheers EJ X

6 Replies

Please make sure you consult your gp before u take anyting, you dnt want to make ur self poorly...mxing some drugs can leave u with nasty side affects if u find one lot of medication dnt work go back to ur gp and ask to try something else

1 like

Hi, no i've even heard of it, where do you get it from? You be very careful, get professional advise before taking it. Good luck.x

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I have never personally tried this, but I want to sincerely wish you all the best of luck with this. Your pharmacist should be able to advise on this matter?

All my hopes and dreams for you

Ken x


Hi, I take 5HTP daily supplement to boost serotonin and help with sleep also, I feel it particularly helps and is essential during winter time. I'm unable to take even 5 mg of Amitryptiline as not able to tolerate the side effects so can't give my experience with contraindications on taking both. Yes, as the others mention best under medical supervision.

Your mail prompted me to find out more and I came across this link which may be of interest.

5-Hydroxytryptophan (5-HTP) | University of Maryland Medical ...

umm.edu › altmed › supplement

Best Wishes Alice


Hi all, I would not try the 5- htp without speaking about it to g.p first to see what he says, because if I tried it and had a bad reaction without telling him it would be embarrassing having to tell him I had taken it!!

So don't worry I wouldn't just buy it until I had spoken to him


I take 5HTP and it has helped my depression. I also take a small amount of one of the SSRI antidepressants. The thing is, if you don't have enough serotonin in your system, an SSRI, which keeps serotonin in your system longer, does not have much to work with. I believe you can get serotonin tested, and it would be good to learn about serotonin syndrome, which you get if you have too much.


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