Fibromyalgia - Neuroinflammatory Disease?

[Ian123]

From health rising for your consideration

cortjohnson.org/blog/2015/1...

[Regnofibro1]

The only problem is I am allergic to antidepressants. Some literally stop my heart. It's interesting to see that research. I hope it can help a lot of people!

[Ian123 in reply to Regnofibro1]

A reason for future research that uses an alternative method of reducing neuroinflamation because you are a long way from alone with an intolerance of antidepressants. Keeping the autonomic nervous system balanced whilst changes in lactate levels are made will be a major challenge.

[Natura]

Very interesting....always believes this all stems from something going on inthe brain...thanks for. Sharing.

[Ian123 in reply to Natura]

Always interesting getting other views, though we share a common belief in something going on in the brain that should not.

[rosewine]

Very interesting reading there were one or two bits above my head but it does make alot of sense.x

[Ian123 in reply to rosewine]

We get a diagnosis not a doctorate from the hospitals. Going on what makes sense from our own experience is top drawer for me.

[Shadows-walker]

That really interesting going to mention this to my gp going to print it off for him to have a read thanks Ian , hugs.

[Ian123 in reply to Shadows-walker]

Your welcome as always

[littleeffie]

Very interesting and thanks for posting .

Mind you it says brain? I have heard of them but don't think I remember having one so that might be part of my problems .

Well there you go at least someone is taking an active interest and if you have one of those gps you can tell them that they were right it is all in your head Literally!

Same as first post adverse reactions to antidepressants and gab meds.

Have a lovely evening.

[Ian123 in reply to littleeffie]

In your head but not in your imagination as was suggested by many that had no better answers at the time. With neuroinflamation a hypersensitive nervous system will likely need delicate changes in brain chemicals, greater subtlety than one size fits all dose rate currently the fashion.

[TheAuthor]

Thank you Ian123, that was a very interesting and eye opening read! I genuinely hope that one day we can say for sure what Fibro actually is and that everyone agrees that it is correct and researches then come up with suitable treatments.

All my hopes and dreams for you

Ken

[Ian123 in reply to TheAuthor]

Hopeful I will see better treatment sooner rather than later for everyone.

[achydunlin]

Very interesting, but I wonder about the clumping together of CFS and ME - I read somewhere (I will try to find the article) that they are completely different conditions (although a person can have both) and medical professionals do confuse the two.

It's interesting that they say it's inflammation of the neuro system.. I was found to have paired 'o bands' in my spinal fluid and one doctor said there was system-wide inflammation.

I am a bit concerned though about the number of subjects in the study - 34 altogether. that seems a bit low (speaking from a science grad point of view) it would be interesting to see further studies.

[Ian123 in reply to achydunlin]

CFS is an invention sponsored by the medical insurance companies that do not pay for mental health it was brought into play during the 80s as a dustbin diagnosis for unexplained illness.

The Institute of Medicine would like CFS replaced with SEID as ambiguous criteria have poorly served the clinical,research and patient communities.

Jared Younger and Leptin as further study suggestion of material.

[Hidden]

I'm a bit sceptical. Firstly, because there is no clinical evidence of inflammation in FM. Secondly, because there is a comprehensive review that found the medication they are discussing actually did not cause much more symptom relief than the placebo.

That post also lumps together CFS/ME and FM which always makes me feel uncomfortable.

[Ian123 in reply to Hidden]

There is clinical evidence of micoglia activation causing neuroinflammation.

Not much more symptom relief may not be statistically significant for researchers, in clinical settings how many will refuse symptom relief with few side effects.

Estimated 40% of ME/CFS have FMS as a comorbid condition avoiding lumping is far from simple.

[Hartleyhare2]

There are two points that stick out for me here. Firstly I have never seen a neurologist but I believe fibromyalgia belongs in their realm and pain specialists/physio rather than Rhumetologists.

Secondly I am comfortable with CFS, ME and Fibro being used within the same context as there are so many overlapping features. Could it not be that there is a spectrum that spans all these conditions and also allows for other symptoms to be factored in too?

Patrick

[Ian123 in reply to Hartleyhare2]

Other neurological conditions have been through this process Parkinsons was The Shaking Palsy and the dopamine brain reaction was not found until the 1960s. MS was Hysterical Paralysis and again the domain of psychiatrists until accepted as a medical condition into the 1950s and 60s.

Dr Lucinda Bateman believes the similarities between CFS/ME and Fibromyalgia increase with the severity of the condition so that in the most severe cases, telling them apart becomes almost impossible.

Coming from different points in the spectrum into a common meeting point where most features of both conditions present.