APS & Infertility – Which Antibodies Were You Tested For?

[tsisanoe1986]

Hi everyone,

I wanted to reach out because, like many of you, I’ve been on my own difficult journey with pregnancy loss and searching for answers. After my miscarriage, I started digging deeper and eventually learned about Antiphospholipid Syndrome (APS)—a condition that can cause recurrent losses and failed IVF cycles. But what shocked me was how hard it is to get tested for it.

💬 If you’ve been tested for APS as part of your fertility journey, I’d love to hear your experience:

Which antibodies were you positive for?

Anticardiolipin (aCL)

Anti-beta2-glycoprotein I (anti-β2GP1)

Lupus anticoagulant (LA)

Did your doctors test for all three, or just some?

Did you have to push for testing, or was it offered to you early on?

If you were diagnosed, did aspirin, heparin, or other treatments help?

I’m now working on developing a faster and easier APS test that fertility clinics could use right away, so people don’t have to go through multiple losses before finding out. Right now, APS testing is slow, expensive, and often overlooked—we want to change that.

If you’re comfortable sharing, I’d love to hear your experiences. Your stories could help shape a test that gets people the answers they need, sooner. 💙

Thank you so much! Sending love to everyone on this journey. 💕

[Sharbertn]

Hi,

was tested for all three and some other stuff too at the time (clotting screen and ANA. I was very lucky and managed to get this after 2 failed implantations and 1 chemical (if you can call that lucky but most don't get it until 2/3 miscarriages).

My Anti-B2 glycoprotein IgM and Anti-cardiolipin IgM were both high but IgG's were in range and I had Lupus Inhibitor Demonstrated. Based on this I am going to be using aspirin and clexane. I have not done any transfers since this diagnosis so can not say whether this is going to help or not.

That is great that you're looking into a quicker more cost effective testing, may I ask what area you work in?

[tsisanoe1986 in reply to Sharbertn]

Hi,

Thanks for your message! I really appreciate you sharing your experience.

ArcLight’s APS biomarker test works similarly to a lateral flow test but is faster and more precise. It’s designed to detect APS-related antibodies quickly, making it a more efficient and cost-effective alternative to traditional testing. The goal is to integrate it into IVF and unexplained infertility diagnostics, helping patients get the right treatment sooner.

I work in translational cardiovascular therapeutics, but my personal experience with APS has led me to focus on improving APS testing accessibility. Right now, I’m developing an Innovation-to-Market (I2M) strategy with London Business School and UCL to bring this test into clinical use, especially in fertility care.

I had a chemical pregnancy after my first transfer too, pushed for answers and was prescribed aspirin and fragmin. I had second transfer which led to our lovely almost 3-year old daughter. I wish you to meet you rainbow baby soon! Wishing you all the best on your journey, and I’d love to hear how things go for you!

[DianeArnold Partner Nurse Fertility Network UK]

Hi. Have you had a look at thr HFEA website to see what tests are best hfea. gov. Uk

[tsisanoe1986]

Hi Diane. Yes, I did. However, it seem unfair that the tests are only offered only once miscarriages occur (or 3). So I wanted to find out patients' experiences and how they felt about the testing and the treatment