I have found out I am positive for the gene Kir AA through my Spanish clinic. Complex area but may explain my miscarriages and difficulty getting pregnant over last 3 years. We are going for donor eggs in Spain now. No consultant has ever tested me for this gene in the UK. It’s a bit similar to NKC issues however I am normal for that test.
we now have to find a donor with specific genes (HLA11) so that my body doesn’t reject the embryo and also less chance of pre eclampsia with this type of embryo gene (another risk for me carrying this AA Kir gene)
Feeling rather blurgh about it but have read a lot.
Has anyone else found out they have this gene AA Kir? If so how did you get on?
Was it natural pregnancy or donor? Do you have any good areas to read about as I’m just getting my head around the HLA concept too ?
thanks very much I appreciate it if so x
Sarah
Written by
Sarslouise
To view profiles and participate in discussions please or .
Hi. I wish you well with this as it can’t be easy for you. Anyone replying please be mindful re advertising and reply by PM if necessary. Good luck. Diane
hello! Yes I was tested and I have this gene too. KIR AA is more likely to reject ‘foreign’ things, like sperm/embryo etc. it particularly rejects embryos that have an ‘hla c2’ gene. So if the sperm provider or egg donor have that then they are more likely to be rejected. My husband had that Hla c2 gene. We had had two failed transfers of tested embryos when we found out. For KIR AA they will normally give you a drug called ‘Neupogen’ - this is what I was given, I took it every few days from transfer till 10 weeks pregnancy and that was the key that helped me keep the baby. I did develop preeclampsia though in the end but all was fine and I had a c section just before 37 weeks.
Thank you SO much for your reply - I felt I was alone with this gene. So pleased to hear you had a successful pregnancy and delivery. Congrats!
That’s great to know about the drug too. I have a no of qus for my clinic, so I’ll add that to it
I’m not sure if they tested my husbands HCL genes but again I’m going to ask as it seems more of an issue if he’s HCLA2 as you say. Also hence they need to find a donor who is HCLA-C1C1 - which of course cuts things down a bit in terms of donor options. So I have to be patient.
Still wonder why I wasn’t ever tested with my UK clinics - they liked to blame it all on my age sadly which isn’t 100% the case it seems - I am super healthy with regular ovulation and periods. But I have to move forward now
It’s not widely tested in UK, the science is ahead in Spain and other parts of Europe. Our clinic, though in london, was a Spanish company so they recommended it. We ended up seeing their reproductive immunologist who specialises in it (she was based in Spain so we saw her remotely) and that is how we were able to move forward etc. Really hope you manage to find a donor etc, but yes I imagine it’s harder when you have to test them etc. Hopefullh your clinic will give you lots of help xx
Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.
Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.
Another failed attempt - losing hope 
PGTA result gutted
Overseas for donor embryos
Success stories please with top grade embryos 
