Morning all
Would you mind sharing what medication doctors have recommended for repeat miscarriages. And whether these were taken in preparation before another embryo transfer or during an IVF cycle. And if you had success!
I have had 2 early miscarriages and a chemical in the last 3 years and would like to try something else before we look to transfer our frozen embryo.
🙏 thank you xx
I meant to say, I have used high dose progesterone including prontogest injections and cyclogest, Intrelipids, Blood thinner (inhixa), baby aspirin and still miscarried so looking for additional options to treat immune issues. One medication I read about is prescribed to treat Lupus and Rheumatoid arthritis called Hydroxychlorquin which people report to have helped them stay pregnant. Anyone have experience of using this medication and if so how long did you take it for and what was your dose? 😊
Sorry to hear about your miscarriage. I paid private for blood tests ager miscarrying, the Antiphospholipid tests and they'll only give you blood thinners if it's positive. It's the Anti B2 Glycoprotein Abs that could be different medication. But there is many many blood tests they can do, thyroid, endocrine etc.
If you look on Tommy's website There are loads of tests that can be done, including lining tests, ensuring your tubes don't have hydosalpinx, Hystersalpinogram x-ray with dye to ensure you have no adhesions or scarring in your womb.
I've attached a screenshot I took of private tests you can pay for from University Hospital Coventry & Warwickshire with Professor. Brosens if you don't want to wait for the NHS to refer you after 5 miscarriage. Best wishes x
Images are hidden by default on this community.
I’m so sorry for your losses 💜 it sounds like you have tried all the usual things. if implantation is happening it could be the actual embryos, are you doing PGTA? I just had to keep transferring until finding the right embryo at the right time though. Xx
That is our thoughts too. The issue we have is that we only get a low number of blastocysts each cycle. Even with donor so didn’t want to risk testing and not having anything to transfer.
I’ve been referred to recurrent miscarriage unit today so hope to get an appointment in 6-8 weeks. They apparently will do some blood tests which is good, have read they test for antiphospholipid (aPL) antibody which if positive can affect the blood supply to the fetus. If positive, I can then add any new meds needed and rule out uterus issues if they scan me and deal with anything that comes up ( I had a laparoscopy a few years ago and all was okay). Then we can hopefully narrow down if it’s an issue with me or possible sperm issues. (We’ve had sperm sos test and no dna issues were found). It’s exhausting!
Thanks for replying xx
I meant to ask, how many transfers did you do until success? Did you have early miscarriages or did they not take? xx
I think it was 11 transfers in total some of them doubles. We didn’t PGTA test for the same reason 1-2 blasts each cycle so just transferred them back, only once did we get 3 blasts. I had a mixture of negatives and miscarriages, one of the misscariages being at 9 weeks with slow growth so I kind of knew it was defo the embryo development rather than the environment. Our last round we got the least number of eggs but made 2 blasts. Fresh transfer didn’t work BFN but the frozen one did and now 25 weeks so hoping this is the one! Other than taking COQ10 higher dose I did nothing different that round. It was a down reg medicated FET with added lubion and clexane. The down reg FET worked with my son too so I’m not sure if maybe that helped me personally too? Although I’ve got pregnant with fresh transfers as well, albeit early losses. I honestly don’t know what’s made the difference this time! Xx
Thank you for sharing. Similar to us then. This pregnancy a heartbeat was seen at 7.5 weeks but baby only measured 5.5 weeks, the next scan a week later it had grown to 6.1 weeks but sadly the heartbeat had stopped. It’s so frustrating as I seem to get pregnant now we’re using donor eggs but can’t sustain it. I am going to ask the early pregnancy clinic about testing for APL. Hoping it may be the answer. Take care and enjoy the rest of your pregnancy 😊
Hi. Oh dear I hope you’re keeping plenty of support around.i like to think that your Fallopian tubes have been checked, to ensure any blockages could cause any excess lubrication in them to leak into the womb and prevent implantation. Possibly a hysteroscopy to check womb out and biopsy the lining. Sometimes a low dose steroid called prednisolone in case the body is rejecting the embryos as foreign bodies, heparin or low dose soluble aspirin to ensure blood flow and prevent clotting. All worth asking. Hope all goes well next time. Duane
Thank you for your suggestions x
Hi, im sorry about what youve been through i hope youre doing ok ❤️
I second the biopsy of the lining & hysteroscopy. I did these and ended up having two polyps removed and a positive test for chronic endometritis. The treatment for edometritis is a string course of antibiotics follwed by vaginal and oral probiotics so you could try these things anyway.
With my immune protocol I'm on prednisolone, clexane, aspirin and intralipids. I've also recently been prescribed a medication called tacrolimus which helps your body not to reject the embryo. I saw an immune specialist and discovered I have a partial dq alpha gene match with my partner and we have also had a treatment called lmit or lit (a bit controversial but willing to try anything). A few ladies recommended hydroxychloroquine on here and said it worked for them so worth a try but must start taking it 2 months prior to transfer I believe.
Wishing you best of luck for your next round xx
Thank you so much for replying. I will definitely look into your suggestions. Could I please ask, what blood tests you had done? xx
To be honest there were so so many I had about 17 vials of blood taken. All the general ones, immune panel, Chicago, natural killer cells, karyotype. They found thyroid antibodies, mthfr, high nk cells and the dq alpha gene match which are the reasons for my immune protocol. The only tests I haven't done yet are the ema, era, Alice which I'm thinking to do next and the hsg xx
Hi Jules, I had 4 early natural miscarriages so I understand what you are going through and really sorry for your losses!
We started IVF because of the recurrent miscarriages and we were recommended PGT-A testing all our embryos. Due to low AMH and high FSH we only ever got 1-2 blastocyst and it took us 3 rounds of egg collection to actually find a normal embryo and we also have a mosaic. We did our first transfer in July with the normal embryo and I am currently 20 weeks pregnant.
If recurrent miscarriage is your main issue I would highly recommend PGT-A testing, further down the line I was also told this test is far more superior to the screening the NHS does for down/edward/patau which might be relevant if you are an ‘older’ woman like myself.
For the transfer we also used embryo glue.
I wish you all the best for your next round!
Thank you for your reply 😊
The main reason we haven’t tested the embryos is not having many make it to blastocyst. We didn’t want to risk not having anything to transfer. We’re also using donor eggs so hoping PGT-A testing wouldn’t be necessary due to age of the donor.
The multiple rounds you did must have been tiring, but so pleased to hear it worked for you in the end 😊 good luck for the rest of your pregnancy. xx
Hi Jules . I know how you.must be feeling and hope you have lots of support around you. I would recommend doing a detailed blood profile and checking for antiphospholipid which is very often the cause for recurrent miscarriage and often aspirin and heparin injection is advised ad does really help sustain the pregnancy. Do PGT testing to check for your embryo. I really pray it works for you this time.
Thank you. Yes we will definitely ask the recurrent miscarriage clinic to test (I think it’s one of the main things they test for, it’s on the NHS pages for recurrent miscarriages). We already use low dose aspirin, 20mg per day prednisolone, daily inhixa injections, intrelipids every 4 weeks and we still miscarry. Am hoping the clinic have other medication they can recommend. 🙏
I had the same story as yours. 1 miscarriage and 1 chemical before finally having my bundle of joy. The loss is devastating but most important is to be positive and keep trying. I know it's hard but don't worry too much and engage yourself jn other activities to get your mind off. It's easier said than done but it definitely helps. Talk to someone get some counselling to debrief and get off things off your mind and feel more positive and then go for it. Things will definitely be better this time😘
Thank you, I needed to hear that today. Your message has helped.
Once I get a plan of action for this pregnancy/miscarriage, I’ll definitely feel better. I think it’s worse that I’m not bleeding and the pregnancy is still there. Once sorted I can dust myself off have a rest and then start making plans for next year. We will keep going, as I’m not ready to give up. 😊 xx
Did you use HCQ medication, if so what was your daily dose and how long did you take it for before embryo transfer? Thanks
No i was not on HCQ but everyone is different. If your doctor recommends it there is no harm in trying. Go for it give your 100% . Take your time get as much information as you can.
Hi, I've had 4 miscarriages and currently pregnant. However even on this medication I miscarried before but I think it has helped. Prednisolone 20mg after transfer, was on 5 then 10 then 15 leading up to transfer.. Intralipids, clexane, aspirin and hcq(400mg daily) -which is what someone else has mentioned. I dont have Lupus but the recurring miscarriage clinic recommended it after my 3rd miscarriage.. I tried genetic testing the embryos but those didn't implant. These were my last embryos and not the best grade but one seems to have stuck.. I would definitely have the hysteroscopy though and blood tests to check for anything else.
Hi Snow
It’s interesting that the tested embryos didn’t implant. How long were you taking HCG for, did they recommend so long before a transfer? Have you got to take it all the way through the pregnancy?
I will definitely ask the recurrent miscarriage clinic about doing a hysteroscopy. I should get an appointment in 6-8 weeks but who knows how long I may have to wait for any tests. Hopefully not too long as we would like to transfer our remaining embryo early next year 🙏
Did you do any other blood tests?
For bloods I did all the autoimmune ones and whatever they told me to.. It cost a fortune, hcq I started 6 weeks before transfer and I'm still on it until the end. This was my 13th transfer so it's been a long and expensive process. But very grateful that this one is nearly there
Hi there. Could I please ask, did you take low dose aspirin from day 1 and carry on I.e. taking it for the embryo transfer and onwards after positive test? If so, did the clinic say keep taking it throughout the whole pregnancy too? I ask as I’ve read it’s supposed to help blood flow through the placenta. I wondered if this could help if this cycle works (am day 7 today) and I have a positive pregnancy test. I have been taking it since cycle day 1 but have been told to stop 2 days prior to embryo transfer (like previous cycles). Our baby was small for the number of weeks before we miscarried in December so have asked the clinic if I can carry on taking it in first trimester to help blood flow. Looking online other ladies have taken it day 1 and carried on. The risk I’ve read is low but it can be very beneficial.
I have also been taking hydroxychloroquine for 6/7 weeks so hoping that helps too. 🙏
I hope all is well with you. xx
Hi, yes I took it throughout the whole pregnancy and I think it started before transfer. This time it worked on my 13th transfer and I now have a 3 month old girl. I took aspirin until the night before c section.Good luck and I really hope this one goes all the way for you xx
Wow, so pleased it’s worked in the end. 🙏😊
We did some blood tests that were sent to America or Canada for testing some years ago that showed blood clotting issues and MTHR gene. Hence why I’m using prednisolone, intrelipids etc. I also need to have the active form of folic acid. They were about £2200 4 years ago.
PGTA testing or fresh transfer
What have you done differently to achieve a successful pregnancy with a frozen embryo transfer?
EMMA and ALICE
Sitagliptin 
