failed third transfer with DE

[Ladycoco20]

so here we are ! 5 AA blast donor embryos & 3 transfers & no pregnancy, after my clinic highly recommended the ERA as everything else was “perfect “ last transfer didn’t work .. added one more day of progesterone after era report .

No endo

3 years , pandemic, loads of bloods & scans , ERA & 5 trips to Greece for absolutely nothing .

I’m numb & angry.

Looking to move clinics to Prague & hoping I can connect with any ladies who sadly have found themselves in this situation with deivf ?

This forum has been so helpful x

[Beatrix_K]

sorry to hear this Ladycoco it’s so difficult to get your head around when everything seemed right… But well done for keeping your chin up and keeping looking forward . Xx

[Ladycoco20 in reply to Beatrix_K]

thank you … think I’m more hanging on for dear life 🙃 so confused & I just don’t seem to get any answers without having to pay for more investigations 🥲xx

[Sw1234]

I don't have any experience with DE but had the ERA and it was the second transfer after the ERA that worked for me so there's every chance the next one could be your one x

[Boo718]

I’m so sorry you’re going through this I have been there soo many times. Have you pgd the embryos? What about the Alice and Emma tests xxx I hope you are ok xxx

[Ladycoco20 in reply to Boo718]

my clinic do not test de embryos & we have none left anyway iv had the full era tests done & I needed one day more progesterone xx

[Boo718 in reply to Ladycoco20]

I just wondered as we had a double donor round and they were alll abnormal 🤦‍♀️😩 xxx

[Ladycoco20 in reply to Boo718]

that’s so sad , & also shocking ! Was that in the uk ? Xx

[Boo718 in reply to Ladycoco20]

nope abroad. They offer to check them all as they say quality and age is no guarantee of normality xxx

[Ladycoco20 in reply to Boo718]

wow 😮 I’m going to see if any potential clinics will test moving forward xx

Thanks for sharing

[Boo718 in reply to Ladycoco20]

I honestly would my donor was only 23 xxx

[Chel91]

I'm so sorry to hear, it's devastating. Have you thought about getting a laproscopy to check for / remove endometriosis? I transferred 10 embryos including 1 PGT-A normal embryo with no luck until I had this surgery. I also saw a reproductive immunologist who helped me control the inflammation and immune issues that often occur with this. I believe it made all the difference xx

[Aninha85 in reply to Chel91]

Hey! What were the recommenations? Supplements, diet? I am in the same boat, 5 top grade embryos, all transfers failed, beta was 0 every time. All my hysteroscopies have shown signs of inflammation, I also have endometriosis.

[Chel91 in reply to Aninha85]

The reproductive immunologist prescribed me heavy duty medications, including prednisone, hydroxychloroquine and IVIG. Unfortunately, nothing worked for me prior to this x

[Aninha85 in reply to Chel91]

Thank you so much! For my last transfer I had prednisone and Intralipid, still nothing... I will start looking for a reproductive immunologist where I live, but this might prove tricky.

[Chel91 in reply to Aninha85]

Prednisone and intralipid didn't work for me either. I'm not sure where you live, but there is one in London and one in Athens, they are very few of them unfortunately. Did you also get your endometriosis excised? This is the gold standard I believe. Best of luck to you xx

[Ladycoco20 in reply to Aninha85]

no recommendations as yet ! They say it’s bad luck or a numbers game 😮

They do not believe I have endo & obviously iv trusted their medical opinion

[Ladycoco20 in reply to Chel91]

I had the era in October & no endo was found x

[Chel91 in reply to Ladycoco20]

Unfortunately, the ERA can't diagnose or rule out endometriosis. Endometriosis is only diagnosed through a laproscopy surgery with a specialist.

Adenomyosis and endometriosis tend to co-occur, so if you have signs of Adenomyosis it can be a sign of endometriosis. Period pain is a strong sign of endometriosis, but many ladies have "silent endometriosis", in which fertility issues is the only sign. My doctor believes that laproscopy and hysteroscopy should be standard before saying anyone has "unexplained infertility", as many times they can find the reason with these. All the best to you xx

[Ladycoco20 in reply to Chel91]

I do not have endo x

[Ladycoco20 in reply to Chel91]

iv trusted my clinic & they do not believe I have endo 🤔 all the pre transfer scans I gave here & send them to my clinic in Greece… every single transfer my scans are perfect & so are my bloods … I’m obviously now second guessing it all 😭 would my gp refer me for lap ? Xx

[Chel91 in reply to Ladycoco20]

It really is unfair that clinics often don't mention this as a possibility, the same thing happened to me for several years, and I was fobbed off by GPs too. I would personally consider paying privately for a consult with an endo specialist if you are able to - they can sometimes refer you back through the NHS or give you a letter to take to the GP I believe (but I went privately if I'm honest). GPs are often reluctant if you don't have any "classic" symptoms - do you have painful periods or pelvic pain at all? xx

[Ladycoco20 in reply to Chel91]

The Alice report does clearly state that no endo was found , I hear what you’re saying & thanks for helping . We are taking with a new clinic this week so fresh eyes will be welcomed .

I did have a lap over 10 years ago & they removed a tiny bit of endo .

My periods are sometimes painful probably more since going through ivf & fets for 4 years & im 47 next month so most likely pre menopause as well … deep joy 🥹 xx

[Chel91 in reply to Ladycoco20]

The ERA Alice checks for endometritis, which is a bacterial infection. Unfortunately not at all the same thing as endometriosis (I do hate how they are spelled so similarly!).

Wishing you good luck with everything xx

[Pos1tivelybaby]

So sorry to hear that.

Have you had a hysteroscopy to see that there are no uterus concerns? After 2 failed DE transfers, a hysteroscopy confirmed I had scarring from a previous miscarriage and my fibroids are distorting my uterus. Having surgery next month for that.

It also sounds like you need to move to a clinic that is more open-minded and progressive.

I wish you the very best xx

[Ladycoco20 in reply to Pos1tivelybaby]

iv had the era and no uterus problems x

[Corchi in reply to Ladycoco20]

Heathrow copy is completely different and checks for scar tissue and inside your uterus. Nothing to do with lining. Also unfortunately pgs testing has been banned in many countries as an ethical thing unless you can prove a reason. (Miscarriage history, age I guess etc)

I’m based in athens if you want I can DM you my clinic they are amazing. Xx

[Pos1tivelybaby]

They are very different procedures. A hysteroscopy checks the health of your uterine cavity using a narrow telescope. Most clinics do that before starting ivf treatment.

This link may help:

yourivfjourney.com/hysteros...

[Banana77]

So sorry to hear this xx

[Hidden]

My clinic did a 3D saline scan of my uterus (it was mandatory before transfer). It checked for scar tissue, uterine abnormalities (eg weird shape, heart shaped etc), polyps and fibroids. It made sure your uterus was in 100% top condition for transfer (less microbiome, more anatomy wise). Would recommend one if your clinic offer it x

[Staceywacey]

hi,I’m so sorry your going through this to,I’ve had 8 DE transfers the 1st transfer was lost at 6 weeks then the other 7 all BFN.

I’ve had all the test ERATRIO etc all come back normal.

Apparently everything is perfect 🤷🏻‍♀️ I’m having a break as I just can’t take anymore of this.

Infact this is the first time I’ve been on here in months as I just needed to not see/think about fertility as I felt I really was headed for a break down.

Just wanted to reach out & let you know you are not alone & sending love your way 😊

[Ladycoco20 in reply to Staceywacey]

hi , thank you for reaching out . I’m so sorry to read you are in the middle of this horrific situation like me 😣 iv been awake half the night now doubting every single step of my treatment! We fully trusted our Greek clinic & now it all feels shady.

My inbox is always open if you need a friend xx

[Summertime12]

It could be that you have an immunes issue. Our first cycle failed but 2nd cycle worked after we added immunes treatment and had very close monitoring with a clinic here in the UK.

[Ladycoco20 in reply to Summertime12]

thanks for sharing x

[Nevergu]

I'm on the same boat. 3 x pgt tested embryos with immune protocol from the famous RI in London and not a snippet of implantation. Had endometrium trio tests ( ERA twice with different results) , 2x hystos and for nothing. 5 x transfers in total over 2 years. Just before my ivf journey I had 2naturally conceived miscarriages and nothing. The only thing I haven't done is lap but I consulted with a soevialist in London who did a 3D scan and said all is perfect. I don't have any signs of endometriosis and endometritis biopsy came back negative. I'm about to turn 42. Feel so lost just like you and second guessing all the tests and procedures so far. There must be something that is missing. I'm also getting so stressed over it. Its affecting my life .

[Kimbob82 in reply to Nevergu]

Have you had an MRI to rule out adenomyosis? I only ask because I was always told there was nothing wrong with my uterus and everything was perfect. 6 years of infertility , 15 embryo transfers, 4 miscarriages later on a full immune protocol and they decided to do an MRI as a last resort. My uterus is full of adeno which is not visible on ultrasound. We are now moving onto surrogacy but just thought I'd chime in because adeno can be totally asymptomatic. X

[Ladycoco20 in reply to Kimbob82]

thanks for sharing , I haven’t looked into mri tbh iv been led by my clinic & they haven’t mentioned me needing it but obviously my mind is going nuts now panicking that there is more to it all than I expected… iv had a baby & they told me it’s just a numbers game ! & I had very high chance of conceiving with DE 🫠 x

[Nevergu in reply to Kimbob82]

Hi. Thanks for sharing. I was told by a leading proffesor in the uk I don't have adeno. I suffer from secondary infertility after having my daughter nearly 11years ago. They think I have very strong immune response that destroys all my embryos and makes my uterus unhospitable. I'm waiting for the immunectests to come back to put another protocol together. I will try mri if this doesn't work.