PGT Result X Chromosome Low Level Mosaic

[MollyRobs]

hello, we have had one low level mosaic reported from a recent PGT-A test. The report states “chromosomes impacted: +X” then “low level mosaic”. I’m struggling to research this chromosome defect and whether it’s worth transferring. Would anyone have come across this at all? Thanks

[Habibi87]

Hi MollyRobs I am no expert on this at all, but I wanted to share this. We did PGS for all our embryos (after batching) and one of them came back low mosaic (I don’t have the full details). The clinic recommended using other embryos first but still freezing that one as we might be able to use it after genetic counselling. This happened over a year ago. Less than a week ago I got a random call from the clinic saying that their advice on low mosaic has changed based on new research and that they will now treat them the same as euploid and good for transfer as studies have shown the same chances etc as euploid. I can send you the pdf they sent me if it helps at all ? Wishing you lots of luck in this journey xxxx

[MollyRobs in reply to Habibi87]

wow. Yes please Habibi87. Thanks for replying!

[Jumpppy]

Replied on your other thread. On 2nd pregnancy with low-level mosaic (awaiting CVS results but they tell me it looks really good). Definitely consider using.Here are some articles that may help:

Y.X. Zhang, J.J. Chen, S. Nabu, Q.S.Y. Yeung, Y. Li, J.H. Tan, et al.

The pregnancy outcome of mosaic embryo transfer: a prospective multicenter study and meta-analysis

Genes, 11 (2020), p. 973

Nathan R. Treff, Diego Marin,

The mosaic embryo: misconceptions and misinterpretations in preimplantation genetic testing for aneuploidy,

Fertility and Sterility,

Volume 116, Issue 5,

2021,

Pages 1205-1211

scholar.google.com/scholar_...

sciencedirect.com/science/a...

[Jumpppy in reply to Jumpppy]

Just an update for future mes that might find this thread - CVS results (karyotype + microarray) all normal.

[JA-fnuk Partner Nurse Fertility Network UK]

Maybe you could have a discussion with your fertility dr/embryologist about your concerns

Wishing you good luck with future treatments

Janet

[Chel91]

It's definitely worth transferring! Low level mosaics may as well be euploids basically, they are almost always euploid when they test them at birth. The cells tested come from the placenta, so not actually the baby. I transferred 2 of my mosaics xx