mosaic embryo

[Sansan87]

Has anyone had any luck transferring a mosaic embryo? Or heard of any positive stories?

Thanks!

[Chowlady14]

Hi Sansan, I had a transfer in January and our embryo didn’t survive the thaw on transfer day so we were left with only a mosaic. We transferred it as we were there at the clinic and would still have to pay and had prepared my body etc but it didn’t stick unfortunately. The consultant said she wouldn’t transfer if it didn’t have a chance though. I think if circumstances were different I would have probably done a double transfer with one being the mosaic but we didn’t have any embryos left from that cycle. Currently waiting to see if we can increase my lining this week after egg collection yesterday to do a fresh transfer Thursday. Do you only have the one mosaic embryo? xxx

[Sansan87 in reply to Chowlady14]

Thanks for your response Chowlady. Sorry to hear about your embryo not surviving the thaw. That must have been really tough news

We’re in a fortunate scenario where we have the following

1 euploid

1 (maybe) Euploid - we did the embrace test on this first and it came back as abnormal and then they retested a year later under normal pgt and came back as normal. I’m a bit worried about the fact it’s tested abnormal in one test though - it’s hard to ignore it.

1 mosaic

Maybe we can transfer the mosaic and the euploid and see what sticks.

[Chowlady14 in reply to Sansan87]

I think you have to listen to your consultant but I would be definitely tempted to ask if you could transfer the mosaic with one of the others. It’s such a lot to put our body’s through to get to transfer isn’t it. As long as your comfortable with the risk of twin pregnancy xxx

[Football61 in reply to Sansan87]

Hi - do you mind me asking what the Embrace test is? Not heard of that before. If the embryo came back Euploid after PGT-A testing, that sounds reassuring? Personally, I would probably transfer that one ahead of the mosaic. Wishing you the very best of luck x

[Sansan87 in reply to Football61]

Hey!

It’s a new type of test which is not invasive. It basically tests the fluid that the embryo secretes rather than removing cells from the embryo. Perhaps also why it isn’t as accurate.

[Sansan87]

I’d love a twin pregnancy! My only worry is that the mosaic doesn’t implant/miscarries and impacts the other one

[Ive_K]

Hi there, I had a low mosaic embryo transferred in February and I’m now 13 weeks and 4 days pregnant. So ours stuck.

I’m not sure what your consultant is recommending, but I’d personally go ahead with the euploid embryos for a peace of mind. Good luck! x

[Sansan87 in reply to Ive_K]

Congratulations! That’s lovely news and wishing the rest of your pregnancy goes smoothly. X

[Stylishinsa]

Hi we also had only 1 low grade mosaic last year on our Oct cycle and unfortunately it did not stick, I would go with the euploid first, I would not add the mosaic in with the euploid in the event the bad impacts the good .. all the best

[Sansan87 in reply to Stylishinsa]

Thanks for replying and I’m so sorry to hear it did not stick. Wishing you all the best for future rounds. It’s a difficult journey I know.

[Crisp-monster]

Hi there, once we started PGT (5 failed transfers prior to this) we had 3 embryos, one normal (failed transfer), one abnormal (so didn’t transfer) and one mosaic. I was hesitant to try it as more chance of miscarriage and failed transfer but I thought “ok, let’s try it rather than going through a whole new round and there’s a chance it could work” So we went ahead and now I have a very healthy, energetic 3.5 year old boy! So I would say go for it and I wish you all the luck in the world. We are currently trying for a second but 3 failed transfers and 1 left so once again I’m hoping that will be the one 🤞🏻xx

[Sansan87 in reply to Crisp-monster]

That’s great news. Congratulations it gives me hope! Good luck for your next round!

[HalifaxCalifornia]

yes! Norbert Gleicher, MD, Wrote an article about a success transfer of a mosaic envyto an older woman in 44ish using her own eggs… and had a totally health baby girl… it about 5 years ago ish you probably can find it if you look

[Sansan87 in reply to HalifaxCalifornia]

Wow he’s published so much! Makes me rethink PGT testing altogether!

[HalifaxCalifornia in reply to Sansan87]

I know totally!I didn’t even bother doing it with our because we were so old, honestly didn’t think we had a chance, and our baby is perfectly healthy. Reading that the mosaics can repair themselves was amazing. It made me doubt. the testing altogether. Especially his comment about throwing out thousands of perfectly good embryos because of the tests

[Sansan87 in reply to HalifaxCalifornia]

Yes I definitely agree! I think the whole way they test them and report on them is so bizarre. On the call with the genetic counselor she said that anything below 30% abnormal cells is reported as euploid and anything above as mosaic. So basically you can have someone who has an embryo with 29% abnormal cells as euploid and 31% will show as mosaic! It really makes me doubt the whole thing!!

I’m so pleased to hear you have a beautiful healthy baby!

[Sansan87]

thank you! I’ll have a look!

[Axel131]

Hi Sansan87, there's new literature coming out all the time about mosaic embryos and basically the thinking now is that most embryos at some stage are mosaic because they contain some abnormal cells. It just depends which of the cells that the pgt testing happens to biopsy and test as to the result. Whether these cells are pushed out to the placenta or just self correct, nobody knows and there are many success stories with mosaic embryos, both low level and high level mosaics. Check out the facebook groups My perfect mosaic embryo and pgs/pgta abnormal embryo support. lots of info on there and success stories.

[Sansan87]

Thanks so much. I had no idea there were groups on Facebook about this. You’re so right - there’s so much research now suggesting that they aren’t actually that reliable. Also I just can’t imagine that in natural pregnancies, every single embryo is 100% perfect on day 5!

[Wishinandahopin]

sorry for the late reply! I produced a lot of mosaic embryos for some reason- out of 8 embryos (across 2 cycles) 5 were mosaic. This as unusual and is nothing to do with age etc.

My two Euploid embryos failed to implant. So we moved on to my mosaic embryos (we did do some failed implantation and immune testing in between and changed my protocol accordingly). And my first mosaic embryo is currently lying on my chest breastfeeding- he is 10 weeks.

We did tonnes of research on this and the thinking in Europe now is that a lot of mosaics have the same chance as Euploids - especially segmental ones.

I found ‘my perfect mosaic embryo’ group on Facebook immensely helpful. And the website of ‘Embryoman’ who collates a lot of research and writes them into easier to understand and more concise articles- he has loads on mosaics.

Hope that helps!

[Sansan87 in reply to Wishinandahopin]

Hello!

Congratulations! What lovely news!!!

Yes I did read that mosaic embryos have nothing to with age etc. so interesting to hear yours was successful.

Ours is high mosaic so I’m not that hopeful but I also don’t want to completely disregard it!

Thank you for responding and congrats again!

[Wishinandahopin in reply to Sansan87]

Thank you - we are hoping one of the other mosaics will bring us a future sibling.

If it’s a segmental mosaic whether high or low it’s got a great chance. But even other types of high mosaics have worked for some people - there are tonnes of success stories in the Facebook group 😊

[Sansan87]

thank you! You’ve given me so much hope and good luck for the next one!!!

[HalifaxCalifornia]

found it! thecut.com/2017/09/ivf-abno...

[Sansan87]

oh wow!! What a great article. It’s made me want to even transfer my aneuploid embryos!!!