5th failed FET - dont know what to do next

[Daisy2024]

I did 2 transfers of untested embryo's which didn't take. So I made sure to do PGT testing on embryo's going forward. Next transfer took, but I miscarried at 13 weeks. I then transferred a low level mosaic without success. Most recently I transferred a euploid, blood test beta came back with 17, but today (2 days later it dropped to 9).

What should I do? Just keep transferring euploids until it works?

I am on baby asprin, steroids and progesterone for support.

We are taking serious strain on this journey and feeling mad just doing the same thing expecting a different result. I am 40 years old, and getting a euploid every cycle. I have 2 euploids left and don't think I can do another egg collection round.

What would you do?

[hoping_for_our_time]

Are you in blood thinners? I only achieved implantation once I added these. 3 years and various more failures and miscarriages down the line I've just gone done the route of immune testing and so wish I'd done this sooner.

[Daisy2024 in reply to hoping_for_our_time]

Hi there! I am on ecotrin, which is asprin I take orally. Are you on the injections?

Who did you go to for immune testing? When are you next trasnferring?

[hoping_for_our_time in reply to Daisy2024]

Yes I've been on clexane injections as well as aspirin. I did immune testing at the clinic I'm now with in the Czech Republic. x

[Daisy2024 in reply to hoping_for_our_time]

Oh interesting! I thought Clexane and aspirin did the same thing. I thought clexane was a stronger form of aspirin. I will ask my doctor if I need both as well.

All the best to you!

[Doodlebug23]

I did Bondi protocol for my successful transfer. Prednisolone and Clexane. I was also on progesterone support.

[Daisy2024 in reply to Doodlebug23]

Hi there, thanks for taking the time to reply.

It sounds like I am on a similar protocol. Prednisolone is a steroid and I am on that. I am not on Clexane but oral blood thinners. The Doc has mentioned Clexane, I think I should consider it. Finally, I am also on progesterone.

Congrats on your successful transfer. Has your baby been born yet?

[Doodlebug23 in reply to Daisy2024]

I was taking baby aspirin but I don’t think it’s obviously anywhere close to the clexane. It wasn’t pleasant or cheap but as you know we will do anything to get what we want!

I’m only 14+2 today so it’s still all fairly new and still fresh in my mind the struggle but took to get here. X

[Daisy2024 in reply to Doodlebug23]

Congrats on your news, that is great!

Did you do a transfer with baby aspirin that didn't work and then you moved onto Clexane and it worked? I will def chat to my doctor about taking clexane for my next transfer.

[Doodlebug23 in reply to Daisy2024]

Thankyou 💖

I was taking baby aspirin off my own back - clinic said I could be it wasn’t their recommendation. They added clexane to transfers 6 and 7 and 7 was successful.

[Daisy2024 in reply to Doodlebug23]

Wow you have been in this for the long haul. 7 transfers, I am so pleased with your progress. I hope my journey is the same as yours. Clexane keeps coming up so will def ask my doctor about it.

[Doodlebug23 in reply to Daisy2024]

7 transfers over 18 months so it’s been intense though not as drawn out time wise as a lot on here. My clinic just says it’s a numbers game. My embryos were all untested. I’d def give the clexane a go. Good luck 🤞🏼

[Daisy2024 in reply to Doodlebug23]

I am so pleased with your outcome. Well done for staying the course. Thanks for the luck - I feel like I need it. Beginning to loose hope. But stories like yours make me feel like I am not alone.

I hope the rest of the pregnancy goes well. x

[Doodlebug23 in reply to Daisy2024]

Just know I never thought it would happen. But it has. So it does. I’m sending positive thoughts and vibes your way. You’re not alone. There’s lots of us on this forum who have been there, or are there.

Thankyou 💖

[Daisy2024 in reply to Doodlebug23]

It does happen! Thank you for all the good vibes and support. I am in desperate need of it and am so grateful. x

[Coming_up_Roses]

Have you had any tests carried out? Hysteroscopy and laparoscopy, and blood tests to check for blood clotting or immune issues? Personally I would be checking for an underlying cause, or just to rule things out, before transferring again.

[Daisy2024 in reply to Coming_up_Roses]

Hi! Thanks for the advice. I have had a hysteroscopy and a HSG and everything is fine. I have done a blood test for blood clotting and immune issues. Very slight blood clotting issue so and on blood thinners.

Are there any other tests you can recommend?

[Coming_up_Roses in reply to Daisy2024]

That's good, and hopefully it's just a case of playing the odds. One other thing I thought of... I've previously needed a round of antibiotics after doing the EMMA ALICE biopsy. I had got an infection after a miscarriage which went on for a couple of months with failed intervention and resulted in dysbiosis- so that's maybe something to think about especially if you've had a D&C. Wishing you the very best for your next transfer

[Daisy2024 in reply to Coming_up_Roses]

I hope the odds fall in my favour soon!

My doctor gives me antibiotics before every egg retrieval so I do take. But maybe I need to consider a week to clear all possible infections. I chose not to have a D&C and everything came away with my miscarriage.

[HedgehogMad]

The stats say 3 euploid transfers are needed for a 95% chance of live birth - I'd transfer one more and if that doesn't work reassess. Most likely you've been unlucky so far 🤞 and I say this as someone with recurrent implantation failure who has done a lot of research into the (limited) studies! Sending lots of luck your way xxx

[Daisy2024 in reply to HedgehogMad]

I really hope I am 3rd euploid lucky! Thanks for the encouragement to do one more. Hopefully it has just been unlucky.

Sorry for your experience. It is heartbreaking. Sending luck to you too! Are you going for another transfer? How many transfers have you done? I hope we both get there. xxx

[HedgehogMad in reply to Daisy2024]

Fingers crossed for you 🤞 we've had 7 transfers, 9 embryos - 3 confirmed euploids and 6 untested (but given we make 3-4 euploids per cycle there were likely 3-4 euploids in there). We are now starting an altruistic surrogacy journey with our amazing friend. It was a difficult decision but definitely influenced by the stats. We are in the <1% who failed more than 5 euploid transfers so very unlucky. You have every chance of the next one working 🤞

[Daisy2024 in reply to HedgehogMad]

oh wow, what a journey for you! And so much is unknown - did they give you a reason for he failures? You are so brave to stay true to your dream of becoming a mom. I have thought lots about it and for me, it isn't genetics that makes us parents, rather the love we give to kids. And so much to be grateful for with all these options to be parents these days. All the best on your journey! You deserve all the success. xxx

And thanks for the vote of confidence that the next one should work. I really hope so!

[HedgehogMad in reply to Daisy2024]

I've since been diagnosed with deep infiltrating endometriosis - after our first egg collection I started having awful ovulation pains which have gotten worse after each subsequent egg collection. It is likely that the hormone surge with the egg collections drove the endo. We've been told that surgery might slightly improve implantation rate - but I decided I couldn't do another egg collection which might make the disease worse. So we are saving our last tested embryos for use with our surrogate.

Thank you so much for the well wishes! I know how awful this journey is - I ended up having loads of investigations along the way (you can look at my bio) but none of it made a difference. Sending you lots of luck xxx

[Daisy2024 in reply to HedgehogMad]

Wow, the things women have to go through. What a journey for you. I will check your bio out. I am sorry it has been so tough, especially the physical pain.

Sending you, the embryo and your surrogate all the wishes for your journey ahead. x

[HedgehogMad in reply to Daisy2024]

Thankyou so much lovely ♥️ the same for you xxx

[Seyedeh]

I would do egg collection and store embryo as much as I could “financially and reasonably “and then start to transfer them in casual way in time …only take one rainbow embryo

Not in harry and devestation

Store your embryo and then try one by one

Think of it, like even when people try naturally they try over time and test and it takes different attempts to become pregnant

[Daisy2024 in reply to Seyedeh]

Thank you for the advice! I was on this path, I had 4 PGT test euploid embyros. Now I am down to 2. Life will dictate if I do another transfer or another egg retrieval. It depends on my dates of travel. The thought of another egg retrieval fills me with dread, but its only about 10 days of injections and then the procedure. Thanks for sharing and for the support. It means so much! x

[MVS22]

I did microbiome and infection testing with a place in Greece. You send your samples over (blood/menstrual blood and vaginal swabs depending on the tests chosen). Will PM you

[Daisy2024 in reply to MVS22]

Thanks for this! I have heard about it but don't know that many details. Definitively need to look into this. I have heard great success stories from this approach. I look forward to hearing from you. x

[Nes1005]

Huge good luck to you, I’ve had 5 Egg Collections and 6 transfers in the last 2.5 years. Just had my BFP on Friday from this 6th transfer, the eggs were collected in May a week before my 44th birthday! The last 3 ivfs hadn’t worked, the first did although we lost our boy. The difference on this transfer was blood thinners (clexane) taken earlier from Start of stims, because I’ve recently been diagnosed with sticky blood (APS) and Hydroxy which I started taking around 8 weeks before the transfer. The Hematologist who diagnosed my sticky blood recommended the Hydroxy alongside Clexane. I also take aspirin and steroids but have had these on other transfers. I really believe the Hydroxy and earlier blood thinners has helped get a positive, although it’s extremely early days and I’m living in terror that this will be taken away.

I’ve transferred 14 embryos in total… and had two natural pregnancies ending in loss in between all these ivfs..it’s so so hard to do multiple eggs collections so I hear you, but sending you strength and keep going if you can, hopefully we will all get to our happy ending❤️❤️❤️

[Daisy2024]

Hi Nes1005. Congrats on your positive!!! That is great news! Interesting that you took blook thinners for your egg collections - I havent heard of that. Maybe worth considering.

What a journey for you. It makes me feel like I am not alone on this crazy journey.

How are you feeling about the pregnancy? Are you staying on Clexane, Hydroxy, aspirin and steroids for the first trimester?

I am taking stock of what I am capable of doing right now. I have a doctors appointment tomorrow, so just seeing how it goes day by day. xxx

[Daisy2024]

Hi all, I received the news that my 6th transfer didn't take I was on clexane and baby aspirin, steroids and progesterone. I also took a course of antibiotics. I have one euploid left, so I will do another egg collection. I am also 41 this month so want to make euploids while I can.

I went back and read through all your helpful and supportive messages. THANK YOU for taking the time to help me on my journey. Any advice now? And where are you on your journeys?

Given that there have been 3 euploids that haven't worked (one was a miscarriage) I'm want to get a second opinion just to see if there is anything my doctor is overlooking.

I am also moving to the Netherlands in September so will look into the European offerings as some of you have mentioned.

Please share any other thoughts or suggestions?