Re occurent implantation failure

[GinaUnicorn]

Hi Everyone, we got 3 good quality embryos in december, 1st transfer failed and following 2 ended in early pregnancy loss (bio chemical) in September we have got a re occurent implantation failure appointment just wondering what to expect?? And has anyone had any positive outcomes even though they have had chemical pregnancies. Thankyou x

[Lovemylion]

Hi GiaUnicorn. I'm afraid I cant offer much advice about this but it's something that concerns me about my last couple of cycles so it's nice to hear positive stories. I remember reading about a lady who had numerous chemicals, implantation issues I think her username is Ranchu90 and she is now pregnant. There are lots of other ladies with similar issues too. So might be worth having a chat with her. Good luck! Xxx

[XOXO13]

Hello, I had three unsuccessful transfers with good quality embryos (5AA hatching blastocysts, 4AA and 2x 3AB). My third ended in a CP.

We explored all kinds of evidence based tests such as karyotype screening, HyCoSy, Hysteroscopy etc., and nothing was evidently wrong.

I was convinced my immune system was interfering with implantation because I would always get unwell around transfer with swollen glands and a fever - the clinic didn’t believe in that type of thing and the doctor put it down to stress. Anyway, I moved clinics and explored immunology and it turns out I have elevated NK cells and elevated TG antibodies, both of which are managed with steroids.

For my fourth transfer, I was on low dose steroids and intrapilids amongst lots of other medicine and I’m now 9w5d pregnant with twins.

Keep pushing for answers, they will be there. Good luck ☘️ Xx

[GinaUnicorn in reply to XOXO13]

Thanks for responding, you dont have to answer this but i was wondering what the cost of the tests were?? Weve used our nhs round and as far as im aware the tests they may suggest are not available on the nhs. X

[XOXO13 in reply to GinaUnicorn]

I can’t remember exact costs for everything but if I were to estimate then I think the following:

- hysteroscopy NHS so didn’t pay

- HyCoSy est., £500 but you can also get done via NHS with a referral maybe from your doctor (there’s a long waiting list which is why I paid private to rush it through)

- Karyotype screening for both me and my husband I think was like £350-400, could have been a little less (not available on NHS I believe)

- Immunology panel I think was about £1,300 for my initial tests and I now repeat them every three weeks at roughly £900 (not available on NHS)

So fairly pricey for these things frustratingly and unfairly - I feel like that’s the case in the fertility world! Xx

[GinaUnicorn in reply to XOXO13]

Thankyou for getting back to me! I will have to see what they say in september wont i! Its just so i can prepare myself 😂😂

[DianeArnold Partner Nurse Fertility Network UK]

Hi GinaUnicorn. Oh dear! Not easy to grasp when all seems to be going well, then a negative result. I hope you've got plenty of support just now. Your specialist may discuss with you, the use of low dose soluble aspirin and/or heparin to ensure even blood distribution to your womb and its lining. Also helps to prevent clot formation too. Ladies often eat pineapple core too, as it apparently can have a similar effect. Hope the meeting goes well and good luck for next time. Diane

[GinaUnicorn in reply to DianeArnold]

Yep lots of support, currently going through the end of the chemical pregnancy now

[Marisa32 in reply to GinaUnicorn]

I don't have any implantation issues but I've had chemicals in the past. I was told those are caused by chromosomal abnormalities of embryos. Have you had yours tested?

[GinaUnicorn in reply to Marisa32]

I havent no, as it was an NHS round. So that could be something to look at x

[Lancal]

I could be completely wrong here, but I thought recurrent implantation failure was when there was no implantation at all. Wouldn’t the two chemicals indicate that the embryo implanted and then failed? I’m just looking for clarity on this subject, because I only ever get stark white BFNs!I hope you get some answers at your upcoming appointment. x

[GinaUnicorn in reply to Lancal]

I thought that too, its obviously implanting and then not carrying on. I got to 7 weeks last time it was the scan which showed nothing on it. But thats the appointment shes booked me in for xxx