What tests do you recommend after recurrent miscarriage?

[Becatoms]

Hi all,

I have my follow up consultation with LWC tomorrow.

After 2 chemical and 1 silent miscarriage are there any tests/investigations that I should ask for?

My husband has low morphology <1.5%, so that is also an issue which we may need to also explore.

Thank you 😊 xx

[Hidden]

Sorry for your losses. After my third MC I had a number of tests:

- 7 different blood tests to check for issues with blood clotting etc

- A hysteroscopy to check the inside of my womb

- An MRI to check the whole view

Hope this helps xx

[Becatoms in reply to Hidden]

I’ve had a hysteroscopy, but that was 4 years ago, I’ll certainly ask again- thank you. x

[LuxFleur]

Hello, I'm sorry for your losses. Have your embryos been PGS tested?

[Becatoms in reply to LuxFleur]

Hi LuxFleur, none of our embryos have been PGS tested. Would you recommend this?

[LuxFleur in reply to Becatoms]

Well, the most common cause for miscarriage is genetic problems. I had a miscarriage this past spring and we sent a tissue sample for tests and found out that she had a fatal genetic condition, meaning she was never going to be able to be born sadly. Babies with her condition always die in utero. Genetic tests on embryos are illegal where we are getting treatment, so we can't get them, but they can help you see where the problem might be. If your embryos are normal, then you will know that something else is going on, such as with implantation. If the tests are available to you next time you have embryos, it may be worth finding out. xo

[Jess1981]

I'm so sorry for your losses it's hard enough having one but when it's one after another it is extra devastating 🥲I've had 4 - one before our 2 year old daughter Francesca and 3 in a row since having her. Most of the tests were done when we lost Amelia at 20 weeks the only tests we had was via miscarriage specialist was checking me for blood clotting and thyroid function. Like our Amelias full post mortem all came back "normal ". The miscarriage specialist said the only "proven" treatment for recurring miscarriages was herapin. There is also a trial on using progesterone until 16 weeks even tho the placenta takes over at 10 weeks. I concluded my miscarriages were most likely due to my age (39) and was a numbers game. But my miscarriage specialist did agree to the prednisone that I had had with Francesca due to higher nk cells but it was banned with Covid. For me I think that was the difference and I can say I'm now 10 weeks and so far it's going ok. I do have a list of miscarriage tests that Tommy's emailed me. If you would like I can pm you the list ( as not to clog this page up) I also want to say women with recurring miscarriages do go onto have a baby it is possible. Also even if they don't discover the reason for the losses ( 60% won't know why) does not mean that you can't go onto have a healthy baby Xx

[Becatoms in reply to Jess1981]

Hi Jess, my goodness you have been through an awful lot, I’m so very sorry for your losses, extremely heartbreaking. Congratulations on Francesca, and on this pregnancy, I have everything crossed for you.

If you could dm me the tommys information that would be fantastic, especially as I have the follow up call tomorrow.

Thank you. xx

[ToughCOOKIE78]

Miscarriages happens mostly due to old eggs (more common from 35 years of age) which contain abnormal DNA.So I suggest you do PGA testing to check that your embryos have normal DNA prior to implant them, unless you have other chronic health conditions you haven’t mentioned, so worth asking if they could interfere with the miscarriage.

But 90% of miscarriage cases is due to abnormal embryos DNA.

Your husbands sperm parameters aren’t a worry because with ICSI they can select the ‘perfect’ sperm to inject in the egg so mobility, quantity and morphology aren’t really an issue. Again, if he has DNA fragmentation then that could pose some problems but it’s generally the DNA in the eggs that matters most.

Also, eggs with normal DNA can repair defects of sperm if there are any so again sperm is much less of an issue.

Good luck 😉

[Snow345]

Hi, I would definitely check for NK cells in the uterus. I had 3 failed implantations and then they found this was the cause. I’ve since got pregnant twice with ivf but with intralipids and steroids to treat the NK cells issue. However both miscarriages so now going for a new cycle with PGS testing. If it’s possible you can do both and then be more confident before you try again. Good luck xx