Chances of a PGS normal embryo at 42 years old

[JenRoy]

Feeling very despondent and nervous.

We just did a 4th IVF cycle.

We had a successful cycle in 2018.

And 2 failed cycles in 2020 - rubbish response on short protocol...7 eggs and a double 3 day transfer BFN and then only 5 eggs and a single 2 day transfer.

We then switched clinics and have just had a significantly better result.

16 eggs collected!!

13 mature, 9 fertilised and 4 got to blastocyst.

We opted for PGS testing this cycle due to the high risk of miscarriage and genetic abnormalities.

Out of our 4 blastocysts, only one is good quality and at the appropriate stage for biopsy. The other 3 were allowed to grow to day 7 to see if they got to the right stage but all stopped growing overnight 😢

So...it’s all resting on this one embie.

We’ve only a 20-30% chance it’s normal. And even then it’s not guaranteed it will implant.

Would love to hear stories of hope! Feels like we’re reaching the end of our journey 😥

I don’t know if I should or could do any more cycles.

[LCharlton]

Fascinated to hear how much better this cycle went! I have a friend who successfully had a baby with her own eggs at 43 on her 5th cycle, it was the only one that tested PGS normal - so it does happen even though the decks are stacked against us x

[JenRoy in reply to LCharlton]

It went SO much better!!! We did loads of things differently.

To improve egg quality I was advised by my consultant to take low dose growth hormone (daily injections), Ubiquinol, Resveratrol, NADH, Melatonin and the Zita West pre conception meds

I was on a long protocol and took the pill the month before

For stims I was on Pergoveris (recombinant FSH/LH)

For trigger I took a double trigger x2 Ovitrelle

And stimmed for 13 days with EC day 15

The protocol was so much better. More like the one I’d had in 2018 which worked

My consultant also found a small fibroid which although small was in the worst place so he advised freeze all before any transfer and get fibroid removed ASAP

And they advised taking embryos to day 5

We chose to do PGS

[Crabonks]

Hi there, I'm 42 as well (my 43yo partner had to have his sperm surgically removed due to vasectomy) I had 30 eggs retrieved, 18 mature and only 4 fertilised, 2 made it to PGS testing and only one came back - and it was low level mosaic (Trisomy X) so I had her transferred and am now 8w3d pregnant and according to the doctor everything is going perfect! I'll find out at the 12 week scan if she has TrisomyX or if her good cells corrected the not so good cells Good luck!

[Sunnydance]

Hi Jen, this might be the golden egg 🤞

Intrigued to know about the differences in protocol which led to improved response?

[JenRoy in reply to Sunnydance]

Have replied to LCharlton above. The difference was incredible!

[Florencehill]

Hello, I think you are in with a good chance. I'm the same age as you and in my last round 9 were suitable for PGS. 3 came back 'normal'. (one is borderline - they could not detect that it was mosaic arent and said definitely worth transferring) So my maths isn't great but my odds ended up being a rough 1 in 3. I really hope you get lucky and if not you seem to be in good hands with your current clinic for another go.

[Rainbow2023]

I’m 42 and my last (4th) round result was similar to yours. 16 collected, 7 fertilised (via ICSI) and 2 made it to blastocyst. Both were PGTA tested and we were shocked both came back normal. Keep faith miracles happen 😊

[Lilus_Mom in reply to Rainbow2023]

Omg this is amazing! I'm 42 (almost 43) and undergoing my 4th round of IVF. I'm waiting for PGT result of my last round where I had 2 embryos. This far I've had a total of 10 embryos and have a LLM but no euploid yet. Praying so hard for these embryos and this next round! Did you transfer any embryos yet??

[Rainbow2023 in reply to Lilus_Mom]

In total we had 3 embryos tested (1 from our 2nd round a few months earlier, where 4 eggs were collected and 1 blastocyst formed). This embryo also came back normal and was the first one we had transferred in February. I’m currently 9 weeks pregnant 🥹 Keeping everything crossed for you! 🙏🏽

[Lilus_Mom in reply to Rainbow2023]

Omg girl I'm sooo excited for you that I wanna cry! Thank you for your reply. I'm going to be praying for you so hard for a smooth, pregnancy and healthy baby! Please keep me posted. You can also send me a private chat to stay in touch. I will absolutely love to follow your story, which gives me so much hope. Blessings to you! And thanks for the good thoughts. I need them!