metformin & clomid. Did it work?

[ttcmamma]

Hello everyone. Has anyone had luck conceived with metformin and clomid? If you did how long did it take to work? TIA x

[DianeArnold Partner Nurse Fertility Network UK]

Hi ttcmamma. I don’t know if you know much about how Metformin works, but I will explain as simply as I can, with apologies if you already know. People who are diabetic (I realise you probably are not) - are treated in 3 different ways – diet, tablets (Metformin) or insulin injections. Women who are not ovulating properly and/or do not have regular periods and who are overweight, are often prescribed Metformin. The reason being is that they often have an excess of insulin in their body cells. Because of this the glands in the brain that control ovulation, the pituitary and the hypothalamus cannot get their message through to the ovaries to get them to ovulate properly. Metformin “mops up” the excess insulin to allow the messages to get through. Often it can regulate periods, but ovulation still does not occur. This is when a drug called Clomid is often introduced as well to hopefully ensure ovulation occurs. Metformin allows Clomid to do its job more efficiently.

It all sounds very complicated, but the mechanics of the idea work well. Of course this treatment does not work with every woman, and there is always the possibility that IVF or similar treatments may be required.

Not tried it personally, but I have known several women who have been successful. Diane

[ttcmamma in reply to DianeArnold]

Thank you Diane Arnold. Yes it's been prescribed as I have PCOS. I was already on clomid but didn't ovulate every cycle so my consultant prescribed Metformin as has said to start with 1 tablet and then work my way up to 3 tablets. I really hope this kick starts regular ovulation x

[DianeArnold Partner Nurse Fertility Network UK in reply to ttcmamma]

Hi. Thinking of you. Diane