One ovary over responding and the other under responding- stimulation drugs

[Ranchu90]

I had my ultra sound scan after 6 days of stimulation. My right ovary is looking good 11 big follicles, left one is very slow only 4 big follicles and lots of small ones and this after adding 75ml of Lepori (when I had already 225ml of Meriofert). Has anyone experienced this - one ovary over responding and the other one under responding? 🤔 Will left ovary recuperate until EC?

[AuroraXen]

Hi Ranchu. When I had my last scan a week ago, one ovary had considerably more than the other (11 on one vs 5 on the other). I was happy with that as my first round I had 7 total (and even that I know is great for some of us). It's hard to tell how they're going to behave, especially if you're a bit older like me. We're all SO different. Try not to worry- somd of the small ones might even catch up to the larger ones but even if they don't, there's no reason you can't have a great shot with what you've already got xx

[Ranchu90 in reply to AuroraXen]

Many thanks for your reply. I was hopping to have more follicles this time round as the other 2 cycles I didn’t had as many, never had embryos to blastocyst 🥺. I am quite young (29 years old) but considered by my previous doctor a poor responder to medication 😏

[Caitlin-m]

I also had this and had 7 eggs collected in total. Dr said it was not unusual when we had our debrief appointment x

[Ranchu90 in reply to Caitlin-m]

last time I had 7 eggs collected and 2 embryos to day 3, transferred both and ended in biochemical.

This time I am hoping to have more 🤞but doesn’t look that i will have plenty...

thank you for the reply, good luck to you xxx!

[MumofaSpaniel]

Hi, I had an uneven count with my cycle. Don’t worry it’s about quality and if an egg is in that wee follicles. I Was focused on numbers because it was more chances in my head but then my lovely Nurse calmed me down and reassured me that it was still going well, I had to adjust my dose and collect on day 12. 9eggs from one side and 5eggs from the other X

[Ranchu90 in reply to MumofaSpaniel]

You are absolutely right quality is more important than quantity. Problem it is that on my first IVF try doctors focused on quantity on my second one on quality and both failed. Now I don’t know where to focus ... ☹️

[MumofaSpaniel in reply to Ranchu90]

Focus on yourself be positive and will on your ovaries to produce, sounds stupid but I read a book ‘trying to get pregnant and succeeding’ and it totally changes the way I was thinking xx

[Lojane in reply to Ranchu90]

I think that the differing responses of the ovaries is common.

Regarding quality versus quantity my daughter’s experience is that medicating to get the maximum number of eggs was the right approach.

The first clinic took the approach that getting small number of eggs with a more gentle regime would yield less but better quality eggs. Unfortunately for her that wasn’t the case. After 3 rounds there were none that were euploid ( normal)

She changed clinics and they took the approach that getting the maximum number of eggs gave a better chance of finding that one good one. She had two egg collection rounds back to back designed to collect the maximum number of eggs. It was a very demanding regime but after PGS testing she found that she had a number of euploid embryos and is now 7 months pregnant.

This obviously just one person’s experience but reading up on the research it shows that the more eggs collected the greater the chance of success.

Wishing you all the best x

[Ranchu90 in reply to Lojane]

I always had this in the back of my mind- the more eggs the better chances as on each stage you are losing some of them.

Thank you!

[Cinderella5]

I had one ovary that was lazier than the other, think it's pretty common to be honest!! They canr do anything to bring either one on or calm down the other unfortunately. Good luck.xx

[Ranchu90 in reply to Cinderella5]

Thank you! Xxx

I really thought that is very uncommon, thanks for reassuring me.

[Peony85]

Hi Ranchu, the same thing happened to me on my first cycle. I also didn’t get any to blastocyst but a big part of that ended up being due to sperm fragmentation which we didn’t find out til later. One thing that really helped me was changing the drugs. I was on Menopur on my first disastrous cycle and then changed to Gonal F for my next 2, at a higher dose. I read some articles that Menopur and drugs like it can have negative effects on quality for younger ladies and the synthetic FSH only drugs can be better. Definitely was in my case.

[Ranchu90 in reply to Peony85]

I am using now Meriofert but I think is from the same group of drugs with Menopur 🤔. You made me curious now, I will have few questions tomorrow to my doctor.

Thanks!