Failed in ICSI

[mshf]

Hi, hope you are fine

My husband and I are currently under the care of a fertility consultant, and our repeat test results show that we are dealing with male-factor issues:

The result of TUNEL Test:

2015:count:69 motility:26 abnormal morphology:%95 DNA:%27,DFI:%30

2016: count:24 motility:42.5 abnormal morphology:%98 DNA:%20,DFI:%22

2018: count:12 motility:4.1 abnormal morphology:%95 DNA:%16,DFI:%7

Testicular sonography: Normal

No history of Varicocele

Medical history: hypertension(-),diabetes(-),smoking(-)

BMI:22

Drug use for infertility:

1.Folic acid

2.anti-oxidant supplements

3.Carnitine

4.Coenzyme Q10

5.Fertility aid

6.Zinc

7.Selenium supplementation

8.Vitamins A, C, and E

9.Panax ginseng

We have a history of 3 failed in ICSI.

1.Embryo technique:

2.Embryo glue

3.Blastocyst transfer

4.Hatching

we just want to mentally and physically prepare ourselves as best we can, so we really appreciate any advice you can offer. Many thanks in advance

[Hidden]

Where was it that the failures happened? Sorry if the information is there- I am looking on a smart phone xx

[mshf]

We have a history of 3 failed ICSI in Fertility clinic in Isfahan

[Hidden in reply to mshf]

Apologies, I meant where in the process did the failures happen? X

[mshf in reply to Hidden]

We have 3 embryo transfer but we have repeated implantation failure (RIF). My physician said to me: "Implantation failure is related to either maternal factors or embryonic causes. Maternal factors include uterine anatomic abnormalities, thrombophilia, non-receptive endometrium, and immunological factors. Failure of implantation due to embryonic causes is associated with either genetic abnormalities or other factors intrinsic to the embryo that impair its ability to develop in utero, to hatch, and to implant".The thickness of my endometrium was normal and my immunological factors(anti-phospholipid, anticoagulant, and lindane ) were normal. I did not any uterine anatomic abnormalities. I think the reason for repeated implantation failure is genetic abnormalities or other factors intrinsic to the embryo that impair its ability to develop in utero, to hatch, and to implant because DFI is high.embryologist said to me the grade of your embryo is low and you must transfer blastocyst. I have the intrauterine infusion of platelet-rich plasma (PRP) to promote endometrial growth but we have the failure.

[Hidden in reply to mshf]

Wow, you have a lot more information than anyone else. So ICSI is where they have injected the best looking sperm into the egg. This should mean that would take away (in the most part) sperm issues. Have they suggested any other solutions?

Xx

[Lojane]

As you have been told that the implantation issues are related to the embryo, you could look into PGS ( pre-genetic screening ) if it is available where you live.

Then you could transfer only the euploid embryos containing the correct number of chromosomes. Although there is some debate about PGS, euploid embryos are more likely to implant and less likely to miscarry

[mshf]

Many thanks in advance

[TraceySainsbury Volunteer]

Dear MSHF

I am sorry that we can't provide medical advice, I am sorry that you have been through so much; I see you are under a fertility consultant and hope that they have in person counselling available at your clinic, do ask as often meeting face to face can help you explore options and promote a robust foundation of support as you make decisions and move forwards - however you decide to.

If you are considering changing clinic going along to the different ones and seeing how you feel can also be useful.

If donor sperm is needed than my hope is that your clinic will offer routine implications counselling, I can gladly message you more about this as I am uncertain if donor conception is an option.

I see someone has also suggested genetic screening of embryos prior to transfer, though results look good, the HFEA suggest further research is needed: hfea.gov.uk/treatments/expl...

Do use the forums for peer support and do also use the help line with more medical questions.

Very warm wishes

Tracey

FNUK Volunteer Counsellor