Sign of hope: different stimulation = very different result!

[Gueritarubia]

Hello everyone,

Just had my second egg retrieval: 15 hopefully-soon-to-be-embryos taken out!

Not bad for a 37 year-old I reckon?

My first cycle I was quite chuffed with 8 eggs, but then most were immature. Eventually 5 fertilised but all had cleaving issues, fragmentation and eventually nothing was good enough to transfer.

That was on a long protocol with Gonal F.

The stimulation phase was long (14 days if I remember correctly, maybe even 15)

This time we went to short protocol, Menopur instead, AND a double trigger (two different drugs) to ensure a good final push on the maturation front and this is where it has gotten us. And after only 9 days of injections!

Yes, more pain during pick up, more pain after, but also tons more hope as with nearly double the amount of eggs and some measures in place that hopefully should lead to more success.

I'm cautiously optimistic...

They do make me wait till Wednesday morning though before I'll know how they're getting on. Annoying, as last time it was the next day?!

Also annoying as Wednesday I'll have a training day at work and will need to nip out to do the call - nerve wrecking and going back in after will be a real challenge, especially if bad news...

Hey ho, onwards and upwards.

Just wanted to share this to give those of you hope where the stimulation didn't have the desired result. It might be very different next time!

Good luck to all!

Xx

[NDE1987]

Hey Hun thanks for writing this, i started down regulation yesterday and this is my second cycle. First time i was on bemfola but now i will be on menopur. It's nice to know things worked out different for you. I am 29 and i only had 3 eggs last time around. I was so upset. Hope this round i get more and mature ones. I do wonder about the double trigger, sounds good! Good luck with you results xxx

[Gueritarubia in reply to NDE1987]

Thank you

Fingers crossed the change of regime will work for you too. Maybe ask your consultant about the double trigger? The double trigger apparently is good if you had egg maturity issues - it gives them a harder final push to mature. Someone else on here said she had a double trigger too and it was explained to her that it helps the eggs release from the follicle wall better too. Good luck and keep me posted! Xx

[NDE1987 in reply to Gueritarubia]

Thanks so much!! Hope it all goes well this week for you! I will ask about the double trigger at my next appointment. Last time i had 2 eggs which were borderline mature and 1 was immature. Keep us updated to! Xx

[Gueritarubia in reply to NDE1987]

Keep me posted! Xx

[Gueritarubia in reply to NDE1987]

Hey, how are you getting on? Had my transfer today. 6 top class embies already and another 3 that are catching up. So one inside me now, 5 already frozen and up to 3 more going into the freezer tomorrow. What a change from 8 shit ones to 15 incl 6 AA! Hope all goes well for you!

[NDE1987 in reply to Gueritarubia]

Thanks so much for updating me Hun, I really hope it works out this time for you. I hope the change in medication helps me aswell. Only time will tell, currently still down regulating waiting for my bleed, should be next week sometime and then I can get my first scan booked hoping it dosent take me 4 weeks go down regulate again! Well done again and for having some to freeze!!! Xxxxx

[Gueritarubia in reply to NDE1987]

Thanks lovely. Fingers crossed all will go smoothly for you! Keep me posted xx

[Lizzielizzielizzie]

I'm so glad to hear you had a better result! I hope that my change in regime helps me too. You have given me hope!

[Gueritarubia in reply to Lizzielizzielizzie]

Hi Lizzie, glad to hear I've given you some hope. Where are you now in your cycle? Fingers crossed you have a great outcome...

[Gueritarubia in reply to Lizzielizzielizzie]

I didn't believe my consultant when he said next round might be very different, but now I trust he knows what he's talking about! How are you?

Had my transfer today. 6 top class embies already and another 3 that are catching up. So one inside me now, 5 already frozen and up to 3 more going into the freezer tomorrow. What a change from 8 shit ones to 15 incl 6 AA! So change between first and second cycle is very very possible. Hope you'll follow a similar path!

[Lizzielizzielizzie in reply to Gueritarubia]

Wow that's a great result. I'm waiting for a scan on Monday to see when my EC might be. Baseline scan was more positive... 12 follicles and none below 6mm this time. Am starting to feel hopeful... only got one embie last time and it was a 3 so really want better quality!

[Gueritarubia in reply to Lizzielizzielizzie]

I hope you'll go down the same path as me! I've heard other ladies where the second round was that more successful. Keep me posted! X

[Hidden]

Yeah! This is what happened to me, a bad cycle followed by a great one (menopur + double trigger did the trick). I am now 12 weeks + 1 day, hoping you the best for you in the next few days!!! XX

[Gueritarubia in reply to Hidden]

Thanks Christina, I so hope we're striking gold here! Congratulations to you, you must be over the moon! How are you feeling? Relieved you've passed the 12 week mark I reckon? Enjoy the remainder of your pregnancy, hope all goes well for you! Xx

[Nesfin]

Glad to hear this! Short protocol with a double trigger did the trick for me too 😊😊 Lots more side effects but well worth it so far.. xoxo

[Gueritarubia in reply to Nesfin]

Good to hear from you. Seems a common trick then! Hope I'll have an equally successful outcome as you Hope it's still going well with your girls? Xoxo

[Nesfin in reply to Gueritarubia]

Thanks, I think the change in protocol and drugs are really important, like you I didn't really believe my consultant in the beginning - so glad to be proven wrong! I've been down with all sorts of infections lately but so far the girls seem to alive and well, looking forward to my next scan in just over three weeks ❤️ Fingers crossed for you and your top embie 😘 xoxo

[Gueritarubia in reply to Nesfin]

Thank you Nesfin! Sorry to hear you've been having infections, but glad to hear they don't seem to be affecting the girls. Keep us posted on how your scan goes, so exciting! Xx