How fasting helps Autophagy and boosts's your health.

Hi everyone,

In the poll Ashka9 said about the importance of autophagy, this has come up before so here's an interesting but readable article on the BBC web site on how fasting helps our bodies regenerate nerve cells which's great for long levity and helping to prevent diseases, which all sounds really good to me. 😊

So here's the article:

bbc.co.uk/news/health-44005092

[Hidden]

I've just read the article Jerry which sounds so interested, I really hope that this works with the awful diseases mentioned in the article.

Thank you for posting.

[Hidden in reply to Hidden]

Thanks Alicia and I agree what an amazing tool fasting can be...😊

[Hidden in reply to Hidden]

It certainly can be. I'm pretty sure I could do what Zest does and go without breakfast and then graduate to breakfast and lunch.😀

[Ascelus IF18]

Hi Jerry

Also just read the article and find I can relate to it,I have been fasting 18/6 for two weeks now and already notice improvements especially in my mood swings. The thing I find sad about it(the article) is how they instantly want to develop drugs(loads of money to be made)instead planning how to get the general masses to take up fasting. I am of the opinion that lots of those who survived the concentration camps after being basically starved during their imprisonment lived to a ripe old age and retain the faculties.

[Hidden in reply to Ascelus]

Thanks Ascelus I'm really pleased that you've noticed differences in mood swings and that you're benefitting from fasting. It's also very true that the best things in life are free...

Would you like an IF18 badge?

Jerry 😊

[Ascelus IF18 in reply to Hidden]

I would very much like a badge. Thank you.

[Hidden in reply to Ascelus]

That's great and all done, 😊

[Hidden in reply to Ascelus]

Well said

[S11m Volunteer 70lb IF20]

Hi, Hidden .

(Intermittent) Fasting is about so much more than weight-loss... so it is good to see autophagy advocated.

As Ascelus says - Big Pharma is trying to create drugs to sell us.

Exercise can help you get into ketosis and autophagy - but why do they mention HIIT?

Autophagy is of more interest to middle-aged or old people, so why do they use a picture of a young runner?

Why do they mention intermittent calorie restriction (5:2) when eating 500 or 600 calories in a day would drastically decrease autophagy?

I think "They" are promoting 5:2 in the paper this week - and many people will believe that it is Intermittent Fasting and get disappointing results.

[Stoozie Administrator in reply to S11m]

Re HIIT and autophagy, there are animal studies which suggest HIIT is better at instigating autophagy than longer moderate exercise: ncbi.nlm.nih.gov/pubmed/298...

[S11m Volunteer 70lb IF20 in reply to Stoozie]

I still think that gentle exercise is better for autophagy than HIIT... and I note that the study studies breakdown of muscle tissue.

It is well known that intense exercise... (and, more specifically, weight training with heavy weights) "damages" muscle tissue - which is then recycled ...this recycling might involve the same biochemical process as autophagy - but I think it is no indication of "whole body" autophagy where most or all types of tissue (and bacteria, viruses and rubbish) are recycled.

[Stoozie Administrator in reply to S11m]

I was annoyed with myself for giving a less robust piece of evidence so I also found this: digitalrepository.unm.edu/e...

[Hidden in reply to Stoozie]

This is interesting as I use HIIT training and it does work because its makes our bodies work and come alive, it definitely boosts my feel good factor. 😊

[S11m Volunteer 70lb IF20 in reply to Stoozie]

These "study reports" seem to be deliberately worded so that no-one can understand them enough to criticise them - and I thought that it was well known that you cannot measure autophagy?

[Stoozie Administrator in reply to S11m]

I'll get hold of the full text rather than the abstract and get back to you.

[Stoozie Administrator in reply to S11m]

Ok, so my understanding is that LC3I and LC3II are protein markers, only found when autophagy has been triggered. So by finding it in muscle biopsies after certain types of exercise, they can extrapolate that autophagy has been occurring?

[S11m Volunteer 70lb IF20 in reply to Stoozie]

...and where is any "proof" that:

LC3I and LC3II are protein markers, only found when autophagy has been triggered?

[Stoozie Administrator in reply to S11m]

One example here: ncbi.nlm.nih.gov/pubmed/184....

If I'm barking up the wrong tree with what you are asking for/querying, do let me know, I'm only 6m into understanding this stuff for myself

[S11m Volunteer 70lb IF20 in reply to Stoozie]

Well, logically... if you are trying to measure any biochemical process... you try to find a product (or by-product) of the process that you can measure, and this is what they have tried to do.

Thank you for the explanation - but I am not enough of a biochemist to judge if they have a methodology that works.

[Stoozie Administrator in reply to S11m]

Another article about it here: bitesizebio.com/38040/corre...

[Stoozie Administrator in reply to S11m]

Or for the more visual among us, a diagram: bmcbiol.biomedcentral.com/a...

[cheritorrox in reply to Stoozie]

Erk that is seriously hard work ... think I'll stick with what you all tell me the science means!

[Stoozie Administrator in reply to S11m]

novusbio.com/antibody-news/...

[Hidden in reply to S11m]

Hi S11m thats right and I think that we should promote all healthy aspects of fasting.

[S11m Volunteer 70lb IF20]

Hi, Hidden ...

"thats right and I think that we should promote all healthy aspects of fasting."

I am glad you agree with me... but it is not very clear with what you agree?