In the poll Ashka9 said about the importance of autophagy, this has come up before so here's an interesting but readable article on the BBC web site on how fasting helps our bodies regenerate nerve cells which's great for long levity and helping to prevent diseases, which all sounds really good to me. π
Also just read the article and find I can relate to it,I have been fasting 18/6 for two weeks now and already notice improvements especially in my mood swings. The thing I find sad about it(the article) is how they instantly want to develop drugs(loads of money to be made)instead planning how to get the general masses to take up fasting. I am of the opinion that lots of those who survived the concentration camps after being basically starved during their imprisonment lived to a ripe old age and retain the faculties.
Thanks Ascelus I'm really pleased that you've noticed differences in mood swings and that you're benefitting from fasting. It's also very true that the best things in life are free...
Re HIIT and autophagy, there are animal studies which suggest HIIT is better at instigating autophagy than longer moderate exercise: ncbi.nlm.nih.gov/pubmed/298...
I still think that gentle exercise is better for autophagy than HIIT... and I note that the study studies breakdown of muscle tissue.
It is well known that intense exercise... (and, more specifically, weight training with heavy weights) "damages" muscle tissue - which is then recycled ...this recycling might involve the same biochemical process as autophagy - but I think it is no indication of "whole body" autophagy where most or all types of tissue (and bacteria, viruses and rubbish) are recycled.
This is interesting as I use HIIT training and it does work because its makes our bodies work and come alive, it definitely boosts my feel good factor. π
These "study reports" seem to be deliberately worded so that no-one can understand them enough to criticise them - and I thought that it was well known that you cannot measure autophagy?
Ok, so my understanding is that LC3I and LC3II are protein markers, only found when autophagy has been triggered. So by finding it in muscle biopsies after certain types of exercise, they can extrapolate that autophagy has been occurring?
Well, logically... if you are trying to measure any biochemical process... you try to find a product (or by-product) of the process that you can measure, and this is what they have tried to do.
Thank you for the explanation - but I am not enough of a biochemist to judge if they have a methodology that works.
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