Old Trimix?

[Wolfnbear]

So my Trimix has a use by/dispose after date. Anyone ever use it beyond the date? I found that it certainly doesn't work as well and requires an increase in dosage to be effective.

[Jack71]

I have used bi-mix for over 10 years. I keep it refrigerated, and use a standard starting dose with each new prescription. I also gradually increase the dose over time, and I can go well beyond the expiration date with no issues. I think it should be safe for up to one year with each prescription. The trick is to learn how much to increase the dose each time. Start conservatively, and if all is well, then add slightly more the next time. I typically end up using around twice as much at the end of a vial, with a consistent result.

[JPnSD in reply to Jack71]

6 weeks refrigerated...then falls off dramatically. Freeze any extra vials and defrost as needed. I have never heard of it being used beyond 3 months...seems right from what I learned during Covid period. Tends to create more blood blisters as it gets older.

[Jack71 in reply to JPnSD]

I should amend my previous comments as follows.

Each prescription I get comes in 2 vials. I freeze one and use the other as described above until empty (usually about 3 to 4 months). Then, I thaw the second vial and repeat. I have gone well beyond the use-by date using this method.

[JPnSD in reply to Jack71]

Not had that experience at all. Nor is it recommended by chemists/pharmacists I have spoken to. I have gotten to 8 weeks for something that express in 30 days...but it has not worked past that date for refrigerated.

[Jack71 in reply to JPnSD]

You can keep your vial frozen, and then thaw it by holding in your hand for a few minutes until it is almost all liquid. (Important, as the ingredients don't all thaw at the same rate.)

Extract what you need, and then re-freeze it until the next time. I used bi-mix for over 10 years that way and have never had any problem with extending the time of use. The only effect is the need for a somewhat larger dose as time passes. (In my case, about 10% more every few weeks or so. Be careful to not overdo the increase and keep some Sudafed around in case you go past 2 hours.)

Keep your hands clean, and prep the injection site with alcohol wipes before injecting. I used 31 gauge needles which are small enough to cause almost no pain on injection.