I started penile injection therapy nearly 7 months ago when Cialis stopped working for me after many years of use. Tri-mix was prescribed but within the first month I was in the ER with priapism 3 times!! Next came Papaverine alone, which produced NO erections. Then PGE-1 alone, which caused extremely painful erections that lasted nearly long enough for more trips to the ER. Obviously, I don't tolerate PGE-1 very well. I've been pressing my Urologist to prescribe a bi-mix of Papaverine and Phentolamine but he's not been responsive to my queries about this. Have any of you had a similar experience? How did/does bi-mix work for you?