I am 28 and have been in artificial menaupose GnRH injections with add-back HRT for 3 and a half years continuously, since shortly before my endo diagnosis(under a PMS specialist who is treating both my endometriosis and severe PMS with this treatment - initially thought it was severe PMS my problem). I started for the first year and a half on Prostap with add-back HRT including the Mirena coil. I have always spotted from the start, spotting nearly everyday even if my PMS was shortened and mild. After a year and a half, Prostap was failing, with the reappearance of more mood swings, 'mini-periods' influenced at the same time as my female flatmates' periods, and of course more endometriosis symptoms too. I was therefore switched to Zoladex(still with add-back HRT), and it is the same story: severe PMS has returned, severe mood swings, pains and other endo symptoms, spotting everyday too. What I noticed too is that these injection given to me every 3 months, eventually faded after 2months. I do notice these injections affect my memory and concentration and find myself 'not on the ball', I also have noticed I get bouts of depression around the 2nd week after the injection, and that when the injection fades I get a lot of anxiety I cannot control, depression and mood swings (It is currently very bad, i can't follow myself and my mind that flips between anxiety and depression). These are what I have noticed, however it is so complexe, especially with my continuous spottings that fluctuate between minimal and moderate (which I am convinced affect my moods too and cause me to PMS), it still makes me go 'crazy' and wondering what is me,what is the drugs, the endo back and so on. I am therefore wanting to ask if anyone has/is going through a similar experience in a way or another, or reports of having been on these drugs long term and their effects.
I would also like to inquire if some of you endometriosis sufferers also suffer from severe mood swings and severe PMS (which I never used to suffer from so much until my spotting was 'all over the place' (and this already before being on the long term treatment), which makes me think that endometriosis is subsequently causing all the mood swings and severe PMS?!