Progesterone resistance in endo

[Lindle]

A really interesting article:

ncbi.nlm.nih.gov/pmc/articl...

[Heloo85]

Estrogen builds cells up! Progesterone tears them down! Estrogen thickens the womb, progesterone gets it to shed! That’s why estrogen is responsible for cancers! Simple biology!

Only 9% of people are actually resistant to progesterone!.. Those who likely have more aggressive types of Endometriosis! Progesterone in some people can be life changing! Especially in those with superficial types of Endonetriosis!

Not sure what this article is trying to say to be fair?

Endometriosis is an umbrella term for a collection of diseases that are similar! Just as cancer is for cancer! There’s various types of cancer and various types of Endometriosis! An article like this will put people off trying progesterone because they’ll think it won’t work! Xx

[Lindle in reply to Heloo85]

Oh my! 'Progesterone gets it to shed'? Oestradiol builds the endometrium and progesterone stabilises the endometrium and maintains it ready for a pregnancy. It is the withdrawal of progesterone when the corpus luteum decays that causes the endometrium to die and shed as dead cells and other menstrual debris when its blood supply is cut off. Simple biology.

'Endometriosis is an umbrella term for a collection of diseases that are similar!' There are various sub-types of endo but these are not classed as different diseases.

You have previously claimed I am ridiculous for stating that long term progestin treatment can mask symptoms and lead to progression to deep disease, which is well known. I wonder how you suppose progesterone 'works' in the PGE2 - aromatase - oestradiol feedback cycle that is at the core of endo.

I don't know about putting people off - you are downright dangerous for apparently claiming to know more about endo than the researchers in the field. Perhaps you might let us have the links to your expert papers since you apparently claim that progestins can apparently cure endo which is certainly not something anyone else has proved as yet.

[Heloo85 in reply to Lindle]

Basic biology is estrogen increases cell growth, progesterone decreases cell growth! Not talking about any particular cell, but cells in general! And yes, that includes the womb, hence why progesterone is used to treat hyperplasia or womb cancer! I shouldn’t have said shed, should’ve said decrease in size! Hence why I was talking about cancer not about bleeding from the womb! 🤣

[Heloo85 in reply to Lindle]

The progesterone drop triggers the uterus to shed its lining as a menstrual period. Women who have endometrial hyperplasia make little, if any, progesterone. As a result, the uterus doesn't shed the endometrial lining. Instead, the lining continues to grow and thicken

[Heloo85 in reply to Lindle]

And also, for a matter of fact, progesterone can block estrogen full stop! Most of us, through various pathology are estrogen dominant! We don’t have enough progesterone to block estrogen. Endometriosis is estrogen dependent! Because it’s a growth hormone! Estrogen grows the womb ready for fertilisation, then progesterone takes over to ‘hold’ it! If pregnancy is achieved, progesterone stays as estrogen falls! Cuz you don’t want a womb to keep growing! If no pregnancy is achieved, progesterone drops triggering menses! Jeez, basic biology really!

Progesterone treatment in some women, who can tolerate it, is likely one of the best treatment, especially, as I said, in the less aggressive types!.. A qualified Dr would be best to decide a patients best course of action!.. So I can’t speak for everyone! But not sure sharing an article that makes progesterone sound useless is very helpful! The number of cases it is useless in is minuscule!…

[Heloo85 in reply to Lindle]

Receptor status in endometriosis could be used in a similar way to how estrogen receptor and progesterone receptor status is used in breast cancer for personalizing treatment options," said lead study author Valerie A. Flores, MD, of the Department of Obstetrics, Gynecology and Reproductive Sciences at Yale School of Medicine in New Haven, CT. "Such an approach to endometriosis management could better determine which medication each individual patient responds to and minimize delays in providing the optimal medical therapy."

And it’s not new! It’s already well established in cancer, already! And markers are used to match the right treatment to the right patient!

[Moon_maiden]

I tried Progesterone only before Endo diagnosis, Fibroids at that point. It didn’t do anything to help the pain. I probably had it 2-3 months during which I had the Endo diagnosis and kept on it up until first lap. Zoladex did nothing either after lap. I’m likely progesterone resistant, had Rectovaginal Endo and lots of inflammation. I think I’ve read it correctly 🤦‍♀️😂

I’ve got so far with reading the article.

The Edinburgh research showed that Endo cells work in a similar way to cancer cells and the cancer drug they used appears to work.

I hope they get the resources to expand their research. Pity they can’t just open it up that we pay for it to take part and just monitor if it works or not to get statistics, no blind trialling, just lots of real time individual results.

[Victoria_Sponge]

Thank s for this 👍

[joey81]

This is a great article. Is there a test for Checking progesterone resistance?

[JOSANDY40]

Yes very interesting over insight to these female immune gene changes, including cancer, but still we aren't getting a treatment to stop Endometriosis! Myself on Zoladex for many yrs, though I still had Estrogen present, over time it went higher, yes the extreme pain was alittle better but I was still in pain, the Endometriosis was still growing but at a slower pace. I read a article some yrs ago about a tiny Glands in our head which generally don't do much in adulthood but have been able to create various hormones. The Thymus as well as Pineal gland can also causes the total collapse of the immune system.