I've been on depo for a bit over a year and only now have I noticed I get extreme bipolar-like mood swings right before I'm due for my next shot (I'm talking less than a week before my next depo shot). I'll go from depressed to okay to happy to angry and finally uncontrollable crying. Then I'm back to being sane for a little bit. Has anyone else had this stupid side effect? My poor boyfriend doesn't know what's going on. It doesn't help that I'm the first girlfriend that he's lived with.