I have CFS/me and Zoladex floored me, extreme fatigue, flare up of symptoms and new symptoms. So specialist now recommended fitting mirena coil. I read so many bad experiences of this. Then zoladex I couldn't have predicted I'd react in the way I did - except that ME sufferers do respond badly to hormone treatments as your nervous system is compromised. After 5 + years of fatigue etc that has radically compromised my life - can't work, can't walk far, stand for long etc - it fills me with despair that all the endo treatments seem to equal increased fatigue and more pain with no guarantee of improvement.