Potential mechanism of anti-diabetic activity of Picrorhiza kurroa

Kutki – Picrorhiza kurroa is a powerful Ayurvedic herb used in treating mainly chronic fever, skin disorders and diabetes. It is also used in purgation (Virechana Panchakarma) procedure.

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Picrorhiza kurroa Royle ex Benth. (Scrophulariaceae) is a traditional Ayurvedic herb known as Kutki. It is used as a remedy for diabetes by tribes of North Eastern Himalayan region of India. Present study was conducted to explore the mechanism of antidiabetic activity of standardized aqueous extract of Picrorhiza kurroa (PkE). PkE (100 and 200 mg/kg/day) was orally administered to streptozotocin induced diabetic rats, for 14 consecutive days. Plasma insulin levels were measured and pancreas of rat was subjected to histopathological investigations. Glucose transporter type 4 (GLUT-4) protein content in the total membrane fractions of soleus muscle was estimated by Western blot analysis. Plasma insulin level was significantly increased along with concomitant increase in GLUT-4 content of total membrane fractions of soleus muscle of diabetic rats treated with extract. There was evidence of regeneration of β-cells of pancreatic islets of PkE treated group in histopathological examinations. PkE increased the insulin-mediated translocation of GLUT-4 from cytosol to plasma membrane or increased GLUT-4 expression, which in turn facilitated glucose uptake by skeletal muscles in diabetic rats.

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easyayurveda.com/2014/07/17...

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  • examine.com/supplements/pic...

    This fairly remarkable hepatoprotection from picrorhiza kurroa is limited by its lack of human studies, as despite the multitude of animal research on the topic there appears to only be one study in humans which showed that a very low dose of the supplement (25mg kutkin) was effective against viral hepatitis. Future studies in humans are needed to confirm its protective effects, and currently picrorhiza kurroa is a remarkably promising herb.

  • Yes lalitharao there is lot of research on 'Milk thistle' as liver tonic... Kutki is that way bit neglected.

    here is on study...

    ncbi.nlm.nih.gov/pmc/articl...

    The present study has evolved an appropriate animal model with several features of NAFLD, correlating with those seen in humans. Intervention with standardized plant extracts of P. kurroa regressed several features of NAFLD like lipid content of the liver tissue, morphological regression of fatty infiltration, hypolipidemic activity, and reduction of cholestatis. The present study should be pursued further for drug development based on reverse pharmacology for management of NAFLD.

  • What is the brand name/ medicine name to Milk thistle in India? which compnay prepares it? I enquired in two Ayurvedic medical shops by name 'milk thestle', they are not aware of it. please tell me where can i find it?

  • check nutrilite by amway

  • Amway brand is costly

    I replied him in other thread

    Doctor' s Best Milk Thistle from ebay.in

  • Oh ok Great Shashikantiyengar

    There are many capsules available in market for silymarin...

    And Amway is really costly say about Rs.1700/- per bottle of 60 tabs

    Hmmm therefore I was looking for cheaper option...Let me check results of this patanjalee....

    I will post the results...it will be cheap and nice option I guess.

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