I've been researching N-Acetyl-DL-Leucine (NADL) and its potential benefits for Parkinson’s Disease (PD) and Progressive Supranuclear Palsy (PSP). Studies suggest it may improve balance, coordination, and mobility by supporting neuronal function and reducing neuroinflammation. Some PSP patients have reported enhanced stability and reduced movement difficulties after taking it.
The problem? NADL isn’t widely available in the U.S., and I’m trying to find a reliable source.
Does anyone know where to get high-quality NADL supplements in the U.S. (or an affordable way to import them)? Any insights or experiences would be greatly appreciated!
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deebee114
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According to recent research, N-acetyl-DL-leucine (ADLL) shows potential to positively impact Parkinson's disease, particularly in its prodromal stage, by potentially slowing down disease progression through mechanisms like improving mitochondrial function, reducing neuroinflammation, and stabilizing dopamine levels, with early case studies indicating it may even prevent the full onset of symptoms in individuals with REM sleep behavior disorder (a known Parkinson's precursor).
Key points about ADLL and Parkinson's:
Potential to halt progression:
Early case reports suggest ADLL may be able to halt the progression of Parkinson's disease in the prodromal stage, particularly in individuals with REM sleep behavior disorder, by addressing underlying metabolic dysfunctions.
Neuroprotective effects:
Research in animal models indicates ADLL has neuroprotective properties, potentially by mitigating neuronal damage and reducing inflammation in the brain regions affected by Parkinson's.
Mechanism of action:
ADLL is thought to work by improving mitochondrial function, enhancing autophagy (cellular clean-up process), and potentially modulating the gut-brain axis, which is increasingly implicated in neurodegenerative diseases.
Clinical trials needed:
While initial case studies are promising, larger clinical trials are needed to confirm the efficacy and safety of ADLL as a treatment for Parkinson's disease, especially in the early stages.
It seems to think NALL is the more potent and researched; however it's only available for research purposes (it does give UK labs where it can be bought from).
Mon Pharmacien Conseil: Offers Tanganil Gé 500 mg in 30-tablet packages. Availability may vary, and it's essential to check if they ship to your location.
N-acetyl-DL-leucine and Nutricost Pure L-Leucine Powder are not the same.
N-acetyl-DL-leucine is a modified amino acid with potential therapeutic uses in neurological conditions.
Nutricost Pure L-Leucine Powder, on the other hand, is a dietary supplement that provides pure L-leucine, an essential amino acid important for muscle protein synthesis. It's commonly used by athletes and bodybuilders to support muscle growth and recovery
The availability of N-Acetyl-DL-Leucine (NADL) and N-Acetyl-L-Leucine (NALL) in the US can be challenging due to several factors:
Regulatory Approval
FDA Regulations: Both NADL and NALL are subject to stringent regulations by the U.S. Food and Drug Administration (FDA). These compounds need to undergo rigorous testing and approval processes to ensure their safety and efficacy before they can be marketed as treatments for conditions like PSP and PD.
Market Demand and Supply
Limited Demand: Since PSP and PD are relatively rare conditions, the demand for these specific compounds may be lower compared to more common medications. This can result in fewer manufacturers producing and distributing these compounds.
Supply Chain Issues: The production and distribution of specialized compounds like NADL and NALL can be affected by supply chain disruptions, leading to limited availability in the market.
Research and Development
Ongoing Research: Both NADL and NALL are still under investigation for their potential benefits in treating neurodegenerative diseases. As research progresses, more data will become available, which may influence their availability and approval status.
Availability from Suppliers
NADL: Information on the availability of NADL in the US is limited, and it may not be widely available due to the reasons mentioned above.
NALL: NALL is available from suppliers like Tesseract Medical Research, which offers it as a supplement for neurological health and support.
If you're looking to purchase these compounds, it may be helpful to consult with a healthcare professional or look for reputable suppliers that offer these products.
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Tanganil and acetyl l leucine?
N-Acetyl Semax
N-acetyl-cysteine in the treatment of Parkinson’s disease. 
Is there any treatment for PSP
