Acetyl-l-leucine hepatotoxicity?

[Memento_mori]

Anyone look into this question? Especially at 5 grams it is probably worth looking into. I haven't found anything.

[Flipper_B]

What is your hypothesis? N-acetyl-DL-leucine (which is not the same as N-acetyl-L-leucine) has been around since 1957 without any reported problems in this matter. Why would you want to take 5 grams of NALL? There are scientific reports on N-acetyl-DL-leucine, with the D enantiomer not being methabolised properly in the cells, but this is not the case with N-acetyl-L-leucine.

[Memento_mori in reply to Flipper_B]

You got me there buddy. I guess I am conflating the idea that N-acetyl-L-leucine is the active enantiomer with the 5 grams that were regularly being taken in that one, tiny too-good-to-be true study. So are we thinking it would make more sense to take less? I recognize that this is alla bit risky.

[Flipper_B in reply to Memento_mori]

I am not trying to ”get you”, just trying to understand, and I am very interested in finding the correct dose myself. 5 grams was with N-ACetyl-DL-leucine, which means 2,5 grams of NALL because ”DL” is 50% D and 50% L. I think if you get the N-acetyl-L-leucine it could be enough with 3 grams but it also depends on your body weight.

For me, the risk analysis is:

1. 90-95% risk of developing my REM sleep behaviour disorder into PD within a few years.

2. Unknown and not documented risk of taking N-acetyl-L-leucine.

I am going for the safest of these two: N-acetyl-L-leucine. I am avoiding risks.

[Memento_mori in reply to Flipper_B]

I think that makes good sense, and I will probably reduce the dose somewhat accordingly.Side point, but I do have the suspicion that the risk of progression from iRBD to Parkinson's is somewhat overweighted because iRBD is likely very underdiagnosed, but on the other hand there are ways of accounting for these things statistically. I do wonder.

[Flipper_B in reply to Memento_mori]

It is very underdiagnosed indeed but I have a grandmother and an uncle who died with PD so I think it is genetic in my case and needs to be avoided if possible.