I've been researching N-Acetyl-DL-Leucine (NADL) and its potential benefits for Parkinson’s Disease (PD) and Progressive Supranuclear Palsy (PSP). Studies suggest it may improve balance, coordination, and mobility by supporting neuronal function and reducing neuroinflammation. Some PSP patients have reported enhanced stability and reduced movement difficulties after taking it.
The problem? NADL isn’t widely available in the U.S., and I’m trying to find a reliable source.
Does anyone know where to get high-quality NADL supplements in the U.S. (or an affordable way to import them)? Any insights or experiences would be greatly appreciated!
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deebee114
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According to recent research, N-acetyl-DL-leucine (ADLL) shows potential to positively impact Parkinson's disease, particularly in its prodromal stage, by potentially slowing down disease progression through mechanisms like improving mitochondrial function, reducing neuroinflammation, and stabilizing dopamine levels, with early case studies indicating it may even prevent the full onset of symptoms in individuals with REM sleep behavior disorder (a known Parkinson's precursor).
Key points about ADLL and Parkinson's:
Potential to halt progression:
Early case reports suggest ADLL may be able to halt the progression of Parkinson's disease in the prodromal stage, particularly in individuals with REM sleep behavior disorder, by addressing underlying metabolic dysfunctions.
Neuroprotective effects:
Research in animal models indicates ADLL has neuroprotective properties, potentially by mitigating neuronal damage and reducing inflammation in the brain regions affected by Parkinson's.
Mechanism of action:
ADLL is thought to work by improving mitochondrial function, enhancing autophagy (cellular clean-up process), and potentially modulating the gut-brain axis, which is increasingly implicated in neurodegenerative diseases.
Clinical trials needed:
While initial case studies are promising, larger clinical trials are needed to confirm the efficacy and safety of ADLL as a treatment for Parkinson's disease, especially in the early stages.
Mon Pharmacien Conseil: Offers Tanganil Gé 500 mg in 30-tablet packages. Availability may vary, and it's essential to check if they ship to your location.
N-acetyl-DL-leucine and Nutricost Pure L-Leucine Powder are not the same.
N-acetyl-DL-leucine is a modified amino acid with potential therapeutic uses in neurological conditions.
Nutricost Pure L-Leucine Powder, on the other hand, is a dietary supplement that provides pure L-leucine, an essential amino acid important for muscle protein synthesis. It's commonly used by athletes and bodybuilders to support muscle growth and recovery
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