Caution Regarding Use Of Acetyl DL Leucine

[park_bear]

I want to make sure everyone considering Acetyl DL Leucine is aware of a potential downside.

See here: healthunlocked.com/cure-par...

Please leave any comments at the linked post.

[ghoegap]

Thanks for headsup

[ghoegap]

And what about using acetyl l leucine ( minus the d) ?

[park_bear in reply to ghoegap]

That should be better. Always subject to proof in the clinic.

[Discogs_discogs]

I am trying to wrap my non-scientific head around all of this Information, and I thank you for posting it, Park Bear.

Do I understand correctly that the loss-of-cognition side effect may have been triggered by the D-leucine, but might not be a risk for those who only experiment with L-leucine instead? I remain puzzled.

In any event, I am surprised that a study was published based on only two patients. Two patients is not a study.

[park_bear in reply to Discogs_discogs]

Yes, you understand correctly that the loss-of-cognition side effect may have been triggered by the D-leucine, but might not be a risk for those who only experiment with L-leucine instead.

They labeled their work as a case report rather than as a study.

[Gcf51 in reply to park_bear]

The researchers should run a study with Acetyl-L-leucine. To see if loss-of-cognition still occurs after.

[Rufous2]

I'd add that the loss of cognition might not have been a side effect at all, but simply a coincidence, in which case both enantiomers could be safe.

If one is going to experiment, I think it's "safe to say" N-acetyl-L-leucine (NALL) is the "safer" way to go. If you can find it.

[Discogs_discogs in reply to Rufous2]

I see a dozen different brands of the dietary supplememt L-Leucine for sale on Amazon. However, those are not acetylised forms of L-Leucine. If one takes the normal supplement, L-leucine, this is what Wikipedia tells me happens next:

"Around 40% of dietary L-leucine is converted to acetyl-CoA, which is subsequently used in the synthesis of other compounds. The vast majority of L-leucine metabolism is initially catalyzed by the branched-chain amino acid aminotransferase enzyme, producing α-ketoisocaproate (α-KIC)."

I am not a scientist, but it sounds like the acetylisation of L-leucine changes it. For example:

pubmed.ncbi.nlm.nih.gov/343...

And

biorxiv.org/content/10.1101...

[Rufous2 in reply to Discogs_discogs]

Definitely changes it, and changes how it performs in the body, which is why it's considered a pharmaceutical.

I'm not a scientist either, and unfortunately I don't know any chemists whose brains I can pick. Maybe someone knows the author of this Parkinson's blog? journeywithparkinsons.com He appears to have a background that would lend itself to figuring something like this out.

Edit: his biographical page journeywithparkinsons.com/a...