Tanganil and acetyl l leucine?

[ghoegap]

Some people here started with tanganil and some with the acetyl l leucine powder. Curious to know how they are finding it? My hwp started with tanganil but kept on a low dose : 1,500 mg per day now and we reckon he is doing well. It isn't like night and day but there is a real improvement in movement and general sense of wellbeing. It is a full month now.

[Flipper_B]

Yes, I tried it for 12 weeks but have stopped. I got rid completely of my restless leg syndrome. I do not have PD but I have iRBD. Will try N-acetyl-L-leucine instead. I did not get my RLS back although it’s 3 weeks ago since I stopped.

[ghoegap in reply to Flipper_B]

Good news. Also want to transition to acetyl l leucine here

[Flipper_B in reply to ghoegap]

I am not a doctor and cannot advise you on dosage so don’t take this as a professional advice but 1,5 g is in fact a low dose. I took 5 g per day. The instructions with the medication says up to 4 g per day during maximum 6 weeks. It should be adapted a bit on body weight, I believe.

[ghoegap in reply to Flipper_B]

Yes thanks.

[amykp]

Hey...would someone (if anyone taking N-acetyl-L-leucine please comment on the taste/solubility? I bought some, but am a little concerned about the source.

What I bought is VERY sour, and doesn't dissolve in water.

(I imagine Tanganil could taste different as it is the racemic form, though I guess it would be interesting to know how that tasted as well.)

I also realize that taste doesn't prove anything, but it would help! Thanks!

[ghoegap in reply to amykp]

Park_bear commented on the taste. Said the L form has a "single tart taste note" and the DL has an "additional taste note which is not pleasant"

[park_bear in reply to amykp]

Very sour is the correct taste. It is highly acidic due to the added acetyl group. The same is true for NAC - N-acetyl cysteine - another amino acid modified with an acetyl group. This modification makes it easier to be absorbed at the cellular level.

For doing solubility testing I advise you to have a small sensitive scale that reads down to the milligram. These are inexpensive and available at Amazon and other places. The solubility of ACLL is 810 mg per 100 ml of water.

[amykp]

Thanks park bear and ghoegap! I guess it makes sense that it tastes like an acid, since it IS an acid, but I could've sworn I read somewhere that it was tasteless.

Anyway, for anyone else thinking about trying to choke 4g of it down, mixing it in commercially sweetened diluted cranberry juice is working pretty well. I imagine lemonade would too. (In my case, artificially sweetened, since I eat keto, but you get the idea.)

These are tart drinks anyway, so making them a little more sour doesn't seem that unpleasant.

[park_bear in reply to amykp]

I premix the acetyl L leucine with about 25% by weight calcium hydroxide, also known as pickling lime, to counteract the acidity, before mixing it into my bear porridge. If all the mixing is done thoroughly there is no effect on the taste of the porridge.

[amykp in reply to park_bear]

Ha--I was thinking of mixing it with baking soda, or a tums, but then I remembered the great and messy explosions we made in school with vinegar and baking soda and I thought--maybe not.

[ghoegap in reply to park_bear]

What dosage are you on now ?

[park_bear in reply to ghoegap]

1.6 G daily. So about the same as your husband