Some people here started with tanganil and some with the acetyl l leucine powder. Curious to know how they are finding it? My hwp started with tanganil but kept on a low dose : 1,500 mg per day now and we reckon he is doing well. It isn't like night and day but there is a real improvement in movement and general sense of wellbeing. It is a full month now.
Tanganil and acetyl l leucine?: Some people... - Cure Parkinson's
Tanganil and acetyl l leucine?
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ghoegap
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Yes, I tried it for 12 weeks but have stopped. I got rid completely of my restless leg syndrome. I do not have PD but I have iRBD. Will try N-acetyl-L-leucine instead. I did not get my RLS back although it’s 3 weeks ago since I stopped.
Good news. Also want to transition to acetyl l leucine here
I am not a doctor and cannot advise you on dosage so don’t take this as a professional advice but 1,5 g is in fact a low dose. I took 5 g per day. The instructions with the medication says up to 4 g per day during maximum 6 weeks. It should be adapted a bit on body weight, I believe.
Hey...would someone (if anyone 
taking N-acetyl-L-leucine please comment on the taste/solubility? I bought some, but am a little concerned about the source.
What I bought is VERY sour, and doesn't dissolve in water.
(I imagine Tanganil could taste different as it is the racemic form, though I guess it would be interesting to know how that tasted as well.)
I also realize that taste doesn't prove anything, but it would help! Thanks!
Park_bear commented on the taste. Said the L form has a "single tart taste note" and the DL has an "additional taste note which is not pleasant"
Very sour is the correct taste. It is highly acidic due to the added acetyl group. The same is true for NAC - N-acetyl cysteine - another amino acid modified with an acetyl group. This modification makes it easier to be absorbed at the cellular level.
For doing solubility testing I advise you to have a small sensitive scale that reads down to the milligram. These are inexpensive and available at Amazon and other places. The solubility of ACLL is 810 mg per 100 ml of water.
Thanks park bear and ghoegap! I guess it makes sense that it tastes like an acid, since it IS an acid, but I could've sworn I read somewhere that it was tasteless.
Anyway, for anyone else thinking about trying to choke 4g of it down, mixing it in commercially sweetened diluted cranberry juice is working pretty well. I imagine lemonade would too. (In my case, artificially sweetened, since I eat keto, but you get the idea.)
These are tart drinks anyway, so making them a little more sour doesn't seem that unpleasant.
I premix the acetyl L leucine with about 25% by weight calcium hydroxide, also known as pickling lime, to counteract the acidity, before mixing it into my bear porridge. If all the mixing is done thoroughly there is no effect on the taste of the porridge.
Ha--I was thinking of mixing it with baking soda, or a tums, but then I remembered the great and messy explosions we made in school with vinegar and baking soda and I thought--maybe not.
What dosage are you on now ?
1.6 G daily. So about the same as your husband
I'm curious how you settled on a 1.6g daily dose? In the published paper I saw the daily dose was 5g.
Ok, I am not to suppose to rely on Gemine AI. But, I asked: “Will taking N-acetyl-L-Leucine and calcium hydroxide together neutralize the N-acetyl-L-leucine and effect the amount of N-acetyl-L-Leucine absorbed?”
Answer:
It's unlikely that taking N-acetyl-L-leucine (NAL) and calcium hydroxide together would significantly neutralize NAL or significantly affect its absorption.
Here's why:
• Different Mechanisms of Action: NAL primarily functions within cellular processes, while calcium hydroxide is a base that neutralizes stomach acid.
• Limited Direct Interaction: There's no known direct chemical reaction between NAL and calcium hydroxide that would significantly alter NAL's structure or bioavailability.
However, some indirect effects are possible:
• Stomach pH: Calcium hydroxide can neutralize stomach acid, potentially altering the environment where NAL is absorbed. However, the impact on NAL absorption is likely minimal.
• Individual Variations: Individual factors like gut health and overall diet can influence the absorption of both NAL and calcium hydroxide.
My short answer: It’s OK to take NALL with an antacid.
I read the list of contents of Tanganil, and except for the active ingredient N-acetyl-DL-leucine, it also contains calcium carbonate. This is most likely to increase the pH to a level suitable for the stomach and to swallow. My plan is to weigh the pills and see how many milligrams of inactive ingredients there are and make my own mixture approximately with the same relative mix(edit: but using N-acetyl-L-leucine instead). There is also some magnesium stereate in it which is added to make the surface of the pill smoother. Magnesium stereate is probably not necessary as long as you don’t manufacture pills with professional machines. Would love some comments on this topic from someone who has a better knowledge of chemistry. I asked a lab in Sweden to help me with this but they refused when they found out what I wanted to do.
BTW I am now off the Tanganil since 4 weeks and I had zero bad dreams, talking or kicking or any movement while sleeping. I have never experienced such a long period without symptoms since it started almost 2 years ago. So knock on wood it seems to be working!!
Sorry, you are off of the tanganil because tanganil gave you bad dreams etc. , or because tanganil stopped your bad dreams? Have to ask because your sentence allows for two contradictory results.
Sorry, I wasn’t clear. I took Tanganil for 12 weeks and did not see a clear decrease in bad dreams, but I was already very low on those and had only one mild dream every ten days or so. But after I stopped, I had zero dreams, now 4 weeks in a row. So, yes, I think NADL or NALL is working in my case. I also got rid of most of my restless legs syndrome.
Is your RLS still reduced, or gone? Did the Tanganil work right away? Did you slowly wean off any RLS medications (ie: Mirapex, or other)?
Good questions! It seems that the RLS is slowly coming back, last night I got up to walk a little. The Tanganil seems to work faster for reducing RLS but it is also coming back faster. I have never used anything for the RLS (except Tanganil).
How much time went by after you stopped taking Tanganil, until the RLS came back? It sounds like you might need to continue Tanganil at a lower does indefinitely.
Hard to say but perhaps a month? Yes, it could be a good idea to continue with Tanganil in lower dose. On the other hand right now I want to see if my nightmares will come back. I believe they will because Tanganil is probably not removing the basic cause of the disorder, even if it would reverse the damages in the brain. So I guess it will be necessary to take it forever, but I’d rather take a cure at a high dose for a few weeks and then stop, and then start again. Just a gut feeling I have.
7 weeks from now I will have a brain scan and that could give me more information on what to do.
A question for those of you using acetyl l leucine powder...is it from Mark Nature or is there another source? Also, has anyone tried to fill their own capsules to avoid the taste issues?
That’s my plan, it is possible to buy empty capsules and there are very cheap fixtures for filling manually. I am planning to mix NALL and calcium carbonate to get the pH up a bit. Right now I am away for a long stay but will do this when I get home in April.
Not sure I see the point of adding the calcium hydroxide if you're going to capsulize the NALL. The calcium is added to make the substance more palatable, but if you're swallowing capsules that isn't necessary, since you won't taste it anyway.
If you're worried about the acidic effect on the stomach, much easier to just chew an antacid when you take the NALL. This will also save you on capsules, and a lot of work filling them, since 1 gram of NALL fills a very large size 000 capsule all by itself, and that's when tightly packed. If you use smaller capsules for more comfortable swallowing, you'll be filling a lot of them, since the appropriate dosage seems to be between 2 and 4 grams (2000 to 4000 milligrams.)
The prescription med Aqneursa comes in packets, each containing 1.7 grams of granules, of which 1 gram is levacetylleucine. The dosage for anyone weighing more than 35 kg is 4 packets (4 grams) a day. So for those who want to try the highest GRAS dose, powder in juice might be the easiest way to consume it.
I have just ordered from MarkNature. Been using Tanganil till now. I am comfortable using the product from them as park_bear and another person whose name i now forget verified that that what they received was indeed acetyl l leucine.
Thank you. I'm going to order from them also.
MarkNature confirmed to me that their product is food grade and if it is, it should be OK to take.
A little question about this - is it right that the L enantiomer is the active one but the D seems to help with absorption? Actually I'm not sure where I got that notion. My situation is that I have just a little Tanganil and the big MarkNature bag. Considering combing the two in order to stretch the Tanganil supply.
Do not mix. The D-enantiomer competes with the L enantiomer for monocaboxylate uptake.
See item 7 - Drug Interactions.
aqneursa.com/wp-content/pre...
Thanks. Should one take a break between tanganil and starting acetyl l leucine?
What was the consensus on the development of cognitive impairment in the two patients in the trial? Was that ever explored or explained, or is it still a large concern?
Sorry there are many NALL threads, maybe it was mentioned in another.
Going by the anecdotes I've read on here of people using Tanganil etc, they have generally experienced the opposite of cognitive impairment.
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