Liver detoxification pathways phases 1,2,3

[realk]

S

omehow I feel my "type" of Parkinson's has something to do with liver detoxification pathways...I was exposed to pesticides between my 20-25yo picking up the grapes and another plants, overeating sweets, extreme sensitivity to alcohol and any pharmaceuticals,Nac,ala, sensitivity to vitamins - especially B vitamins make me feel like there is some toxic burden stocking inside me to the point that I am getting really sick having headache heart arythmias, difficulty to breathe.when i stop using it all the symptoms disappear within few days and I am having" only" my Parkinson's ... Any thoughts?

The liver's phases of detoxification play a crucial role in neutralizing and eliminating toxins. An imbalance between these phases can lead to health issues, as toxins are either not processed effectively or remain in the body for too long. Here's a guide to understanding and identifying such imbalances:-

1. Symptoms of Imbalance Between Phases

Overactive Phase 1 (Excessively Fast Phase 1):

Toxins are rapidly transformed into reactive intermediates, but Phase 2 cannot keep up with their neutralization.

Symptoms:

Increased sensitivity to chemicals (perfumes, cleaning agents, paints).

Headaches, migraines.

Fatigue, insomnia, irritability.

Elevated oxidative stress (e.g., accelerated skin aging).

Inflammation in the body.

Underactive Phase 1 (Slow Phase 1):

The body struggles to transform toxins into intermediates quickly enough.

Symptoms:

Intolerance to alcohol.

Slower drug metabolism (medications last longer and feel more intense).

Increased fatigue.

Difficulty digesting fats.

Underactive Phase 2:

Intermediates from Phase 1 are not neutralized and eliminated quickly, leading to their accumulation.

Symptoms:

Chronic fatigue.

Muscle and joint pain.

Weight gain (especially around the abdomen).

Allergies and food sensitivities.

Skin problems (eczema, acne, rashes).

Brain fog, concentration issues.

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2. Laboratory Tests

Blood Tests:

Liver Enzymes (ALT, AST, GGT): High levels can indicate liver overload or inflammation.

Bilirubin: Elevated levels may suggest issues with Phase 2.

Glutathione Levels: Low levels indicate weakened Phase 2 detoxification.

Oxidative Stress Tests:

Measure the level of free radicals and the body’s antioxidant capacity.

Helps determine if Phase 1 is overactive (excess production of free radicals).

Specific Detoxification Tests:

Tests with caffeine, paracetamol, or aspirin:

These track how quickly the body metabolizes these substances, indicating the speed of Phases 1 and 2.

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3. Lifestyle Analysis

Imbalance may stem from lifestyle factors affecting both phases:

Overactive Phase 1:

Excessive alcohol, caffeine, medication, smoking.

Exposure to pesticides and chemicals.

Underactive Phase 2:

Deficiency of key nutrients (glutathione, sulfur, B vitamins).

Low fruit and vegetable intake.

Chronic stress and poor sleep.

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4. How to Balance the Detoxification Phases?

If Phase 1 is faster than Phase 2:

Increase antioxidants to neutralize reactive intermediates:

Vitamin C, E, selenium, zinc, glutathione

[park_bear]

As I understand it you are saying that any of N acetyl cysteine, alpha lipoic acid, and B multivitamins cause you to have headache, heart arythmias, and difficulty to breathe.

I would advise you to consult with a doctor, without delay, about these symptoms, and, yes, get the liver-related blood work you have mentioned done.

We are not in a good position to do diagnosis as compared to a doctor seeing you in person. The doctor can get your detailed medical history, your medication regimens, and is in the position to ask many questions. Plus the doctor is broadly trained in the diagnosis and treatment of medical problems, which is not the case for myself and most others here.

[realk in reply to park_bear]

Thanks for your feedback, park_bear! the problem is that when I start to talk about that with my neurologist he suggests to put me on antidepressants. My liver tests results are within the normal range and he is not going to further investigate..I would need to visit functional neuro but there is only one I know is located about 330 Km who is not covered by insurance ,so I am out of the "game"..

[park_bear in reply to realk]

So this neurologist thinks your problems are all in your mind. It does not strike me that way. It is apparent that you do not agree with that either. It seems to me that getting another opinion is in order, from someone like an internist or even a general practitioner.

[park_bear in reply to realk]

Also, liver issues are not the only possible problem. It could be something like leaky gut, where unregulated absorption of just about anything could be problematic.

[Bracondale in reply to realk]

My gut feeling is that you would be better off seeing a functional medicine practitioner. A lot can be done remotely, though you may need to have blood drawn when finger tip samples or urine isn't enough. An organic acids (urine) test can give a huge amount of information. I think that you are on point that your body is 'permitted' to detoxify when you take these supplements but that the rate at which it is doing so is too much for the liver (phases become unbalanced...phase2 slower than 1.... And often overlooked phase 3 ...bile flow and elimination of stool may not be very good.) Wishing you well!

[realk in reply to Bracondale]

Thank s a lot for your comment , I have acctualy the same gut feeling ..and after the years of surrender when I was trying and adding various remedies I am always coming back to the point ending up with the same feeling of being poisoned from inside ... Wilson's disease was also considered when my symptoms began to get worse 10 years ago as went to liver biopsy...I would really need to visit some functional Medicine MD , but there is no practitioner in my country ..

[Bracondale in reply to realk]

Functional medicine practitioners are mostly not MDs, though some are trained in both (as more and more are recognising the limitations of conventional training!) I do know that some of those in the US and Australia and likely UK too, work entirely remotely using zoom consultations, so where you live need not be a barrier. (Presumably Wilson's Disease was excluded?) I have mast cell issues and a contributing factor was mercury affecting heme synthesis enzymes in the liver (and bone marrow) diagnosed using urine tests. Other deficiencies including B1/thiamine was detected using an organic acid (urine test). So no in-person visit needed.

[Fibro2021 in reply to realk]

Let me ask if you had your blood ammonia levels determined. There is sometimes confusion between the diagnoses of Parkincon's disease and hepatic encephalopathy (HE) due to ammonia. I'm not saying that this is exactly the case in your case, but ammonia detoxification is one of the most important functions of the liver, and the symptoms may overlap.

[realk]

For more details on liver detox phases just google it or chatgpt it...