with high dose thiamine therapy for almost 2 yrs. Diagnosed with PD for 7 yrs. Main issue is increasing stiffness in both legs. I try to do fast walking every day but it is becoming harder and harder. I have been taking a B-complex from Bronson’s which contains 50 mg of B1 everyday, along with 100 or 200 mags of B1.
As my legs have stiffened up (along with more toe curling of my left foot), I have stopped taking the extra B1 for several weeks at a time, but I see no change, I’ll go back to taking 100 or 200mgs of B1. Still no change.
My questions, as I prepare to order more B-complex are: what are the best B-complexes to take. with Dr. Constantine’s recommended low content, and, re the HDT B1, should I try higher or go lower? I take 25/100 Sinemet 4x daily and an increase of a half tablet at night solved for now the legs seizures I was having at bedtime.
I’ll be very grateful go for any input anyone may have to offer on the above and thanks to healthinlocked for this time wonderful site!
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I’ve read and totally appreciated her 2022 book and her generosity. I’m not on Facebook, but joined about a year ago just to have access to the group, but I don’t think I’m on it any more. Thanks for your reply.
I'm not on the therapy (I'm not diagnosed, but fear I will be at my upcoming neurologist appt) but I've been trying to learn about my options. I belong to the Facebook group and have been doing a lot of reading the past week.
From my understanding of the protocol, if what you're taking is oral Thiamine HCL you swallow (not sublingual) then you are still near the minimum recommended starter dose and likely need to increase it.
I'd really recommend checking back in over there, they seem very quick to respond to questions!
After following Dr. Constatine some 3 + years ago, I began my husband on 500mg of B1 thamine HCL from Vitacost once in the morning. I then increased it to once at lunch and then 2 each time. He has been on 1000 twice a day. His feeding himself improved and remains, his OT is good. I’ve been comfortable staying at 2000 daily for years. Go for it!
The working dose could be higher 2000-3000mg. But it coukd be that you need co-factors. You are pulling a wheel but the wheel needs more then b1 alone. B2, niacinamide, b5, b6, biotin, b12, folate, and you need minerals (all of them) to work with b1. Also omega3 could be needed, and coQ10. I use all the b-vitamines and all the minerals seperatly. So I can finetune the dose for each. I also use binders to grab what supplements pull out of the liver and the cells.
Piping Rock B Complex (B100% 360 tablets) is indeed low-dosed and therefore safe, but the choice of 100% of the RDA is rather arbitrary. Each B vitamin has its own specific bioavailability and metabolic effects. The bioavailability of B6 is particularly high, meaning you need relatively little more than the 100% RDA. Conversely, the bioavailability of B1, B2, and B12 is much lower, so higher adjusted dosages are recommended. The 'ideal B complex,' which does not exist, should take this into account.
Additionally, it is not a bioactive B complex, as no P5P is used as a form of vitamin B6. Although the B6 dosage is low, I do not recommend this due to the potential for toxic effects.
While I have not made a recent update, more information can be found in my earlier post:
You must be blind if, after three years at HU, you still haven't taken note of the B1 protocol... 🙂 Nevertheless, I initially chose to monitor and address any vitamin/mineral deficiencies and overdoses (including a severe B6 deficiency). So far, the pursuit of balance in nutrition, supplements, exercise, and stress management has been paying off. In fact, I've been able to go a year without needing medication. High doses of supplements like HDT and extreme diets don't fit into that approach. It's not exactly trendy nowadays to seek balance and nuance, but you don't just throw away a personal success formula. If my situation worsens—and according to my neurologist, I can expect that soon—I will certainly consider HDT.
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Hoping for the best
B1 HCL: before, after or with meal
Dosing Information On HDT / B1 / Thiamine HCL / HCI For New Members Considering HDT Including a Link To Some of Dr. Costantini's Info
