Are you supposed to take your B-1 supplement at the exact time you take your carbidopa/levodopa

[James4K]

I have been taking B1 and carbidopa/Levodopa at the exact same time, twice a day, before breakfast and then before lunch. Would I get better results if I didn't take them at the same time?

[chartist]

Dr. Costantini said that dose timing was not a critical aspect of HDT. With food or without food, with C/L or different time than C/L, he felt it wasn't critical on the timing other than he suggested not taking the second dose too late in the day as it could affect sleep in some of his patients, but not all.

Art

[James4K in reply to chartist]

Thankyou Art !!!

[jujulini in reply to chartist]

And he did say to take it only with water. Not with juice, etc....,

[chartist in reply to jujulini]

Yes, I think he said especially not with citrus type juices and I think the reason why is because they can alter how B-1 is absorbed and he wanted to keep it as simple as possible in order to get the clearest picture of how the patient was responding to B-1 alone. His preference was also to drop most if not all supplements during the B-1 testing phase for the same reason and them adding them back if desired once the correct B-1 dose was found.

Art

[Coot18 in reply to chartist]

I have heard that grapefruit juice interacts positively with C/L

another reason to take B1 and C/L at different times