How to take sublingual B1: As many of you... - Cure Parkinson's

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How to take sublingual B1

Dap1948 profile image

As many of you know, I have had a lot of success with the sublingual version of B1. I started taking it in 2017 and after a few months realised my slowness, my fatigue and my rigidity had all gone. I was diagnosed eleven years ago and since taking B1 have not increased my medication which remains at just 200 mg ldopa per day. Yesterday I came across this very good article on how to take sublingual tablets.

compoundingrxusa.com/blog/c...

Sublingual B1 is thiamine monoitrate and I'm aware that thiamine hydrochloride (HCL) is the preferred form of B1 for oral administration. There has been talk of monoitrate being bad for the kidneys. I checked this out with Dr Lonsdale, a world authority on thiamine and he said "no" the sublingual B1, being monoitrate, is no danger to the kidneys. A sublingual tablet, if taken correctly, goes straight through the skin and into the bloodstream. Because it is so efficient you need far less of it than if you were taking the oral version. I started in 2017 on 1x 100 mg tablet a day and gradually reduced this over time, and now take just four tablets a WEEK.

Because someone will ask, I get the sublingual B1 from -

pureformulas.com/no-shot-b-...

It is very cheap!

It does taste rather bitter but if you keep it firmly under your tongue while it dissolves it's not too bad and you do get used to it in a week or so. Do follow the instructions as to how to take it though. It won't work otherwise.

A doctor friend told me that all tablets would be sublingual if it was possible to make them into tiny enough particles to pass through the skin, as it was a much more efficient way of administration. Perhaps that's why they are monoitrate. Perhaps the hcl version can't be made into small enough particles. I'm just guessing. The main thing is that sublingual tablets can be monoitrate!

I hope this information is helpful.

115 Replies

Very interesting. Do you know if sublingual levodopa exists?

Dap1948 profile image
Dap1948 in reply to Fed1000

I’m pretty sure we would be prescribed it if it did. One of the many things whose particles are too large I guess!

Fed1000 profile image
Fed1000 in reply to Dap1948

It's possible. Thanks

Fed1000 profile image
Fed1000 in reply to Fed1000

Hi Dap, Do you think the effects of levodopa would dissipate if taken in crushed form sublingually?

Dap1948 profile image
Dap1948 in reply to Fed1000

It would only work like a sublingual tablet if it was produced as one with tiny enough particles to pass through the skin. Not many substances are able to be compounded into sublingual versions.

Levod profile image
Levod in reply to Fed1000

Hi Fed1000,

It is my understanding that Levodopa always (and only) enters the blood through the small intestine.

If you crush a regular c/l tablet and put the resulting powder under your tongue, nothing will happen until you swallow it with some liquid and it makes its way to the small intestine.

Note if you crush a regular c/l tablet and stir it into some water then drink it OR crush it with your teeth and then wash it down with some liquid, it will take effect quicker, then a solid tablet, but will not last as long (smaller Tpeak and Thalf).

Lastly there is a c/l ODT tablet (orally disintegrating tablet) formulation, but it is meant for people are unable to swallow a regular tablet, and again it does not do anything until it reaches your small intestine...

Fed1000 profile image
Fed1000 in reply to Levod

Perfect Levod, thanks.

GioCas profile image
GioCas in reply to Fed1000

There is melevodopa that dissolves in water and has a rapid effect, in the trade name in Italy is Sirio.

en.m.wikipedia.org/wiki/Mel...

Fed1000 profile image
Fed1000 in reply to GioCas

Hi Gio' thank you, the product is interesting, I had never heard of it. Are you using it? Do you think it is preferable to Sinemet?

GioCas profile image
GioCas in reply to Fed1000

I Never used but prescribed to me, according to my neurologist it is complementary to the c / L that is a small immediate additional dose for difficult moments because it is very fast, Max three a day.

Fed1000 profile image
Fed1000 in reply to GioCas

Great information as always Gio'.

Levod profile image
Levod in reply to Fed1000

I think it is interesting if you want to go on faster than crushed regular c/l in water (which starts to take effect in about 20 minutes), and don't care how long it lasts (it won't last as long as crushed regular c/l in water does).

I don't know how it is actually dispensed (e.g., as an effervescent tablet or powder), but it may save you the trouble of breaking out the mortar and pestle or chewing regular c/l tablets.

Fed1000 profile image
Fed1000 in reply to Levod

Thanks again Levod.

Thank you Dap1948 for sharing this information. I personally take B12 in sublingual form. But will get some B1 for my hwp.

Good info - out of curiosity, which part of the day do you take the B1?

Ta.

Dap1948 profile image
Dap1948 in reply to Seamus6

I take it first thing, after my water

Thanks Dap,Had an issue with blood pressure rising from the Vitacost HCL. This might give me another shot.

Er5

Dap1948 profile image
Dap1948 in reply to eschneid

Oh good luck

what sign and symptoms did you have that you were prescribed levodopa?Have you had any sideeffects?how much b1hcl were you taking before sublingual? Thanks for sharing.

Dap1948 profile image
Dap1948 in reply to Smittybear7

I took sublingual from the start. I didn’t start with HCL and change. A doctor friend recommended the sublingual version. I’ve had no side effects from ldopa. My symptoms before B1 were rigidity, bradykinesia, tremor, fatigue.

Smittybear7 profile image
Smittybear7 in reply to Dap1948

How long did it take to get relief? I have right side weakness that may or may not be related to Parkinson's. I have a bulging disc L4-L5 with a bone spur pressing on the nerve. When I sit my quadriceps cramp and my big toe cramps and pulls up. Sometimes if I lay a certain way I get the same results. Standing or laying down relieve the pain. Dr wants me to get an epidural and take gabapentin. I'm trying turmeric and arthritis factors for inflammation. They also want to do a nerve conduction test. I have tremors, gait issues with arm swing and slight foot drag and occasional freezing. I sleep very well and have a good sense of smell. Just don't know which way to go. I started PT AND OT EVALUATION but had to temporarily stop due to exposure to cova.I take 500 b1 and many supplements. Any advice would be appreciated. Thanks and I hope you continue to have success with what you are doing.

Dap1948 profile image
Dap1948 in reply to Smittybear7

You have symptoms which people with PD often experience. However you also have other problems too. How long have you been taking B1? Have you seen any symptoms improve since you’ve been taking B1? Sometimes it’s a couple of months before you notice improvements. If you’ve been on 500mg for a month or more with no improvements, it may be time to move to 1000mg of B1 HCL.

Smittybear7 profile image
Smittybear7 in reply to Dap1948

Thanks I had been on 1000mg for about a month and I started having freezing episodes so I cut back to 500mg for a while,,,no change, then took a couple of weeks off and restarted 500mg. That's been about 12 weeks. I'm going through to try 1000mg again. I see my neurologist in October and will most likely agree to start medication .just scared because I don't know if I have Parkinsonism or Parkinson's. With all the tests I have recently had and the cross over symptoms of pinched nerve, osteoarthritis cramping muscle weakness right side ,tremors, I don't know where to start. Any suggestions are appreciated.

Dap1948 profile image
Dap1948 in reply to Smittybear7

It might be time to start medication. See what the neurologist says. I don’t take a lot of ldopa but I wouldn’t be without it!Do you take magnesium? I thought it might help with the cramp.

Smittybear7 profile image
Smittybear7 in reply to Dap1948

I do take magnesium 2 at night. I also take two minerals during the day. What made you go on the medication? Thanks for your help

Dap1948 profile image
Dap1948 in reply to Smittybear7

I didn’t take ldopa until I’d been diagnosed for four years. Everything was just becoming such an effort. I was slow, rigid, tremored... I’m a very determined woman and it felt a bit like giving in, but I felt so much better with a low dose of ldopa.

Smittybear7 profile image
Smittybear7 in reply to Dap1948

Good to know. Sounds like what I am experiencing. How long did it take for you to get results?The cramping and weakness are getting. me down. How did you get diagnosed?

Hikoi profile image
Hikoi in reply to Smittybear7

If you took some sinemet Smitty bear i believe ALL your symptoms would be relieved. incuding your so called pinched nerve. As to whether you have Parkinsonism or Parkinsons what difference do you expect that to make to your treatment? If you got the idea it was Parkinsonism from a doctors letter then you need to know that is universally used by neurologists at first diagnosis.Later they will write Parkinsons (or one of the Parkinson Plus conditions if that is what you have.) Parkinsonism is just an umbrella term.

Smittybear7 profile image
Smittybear7 in reply to Hikoi

Thanks for your help

Hikoi profile image
Hikoi in reply to Hikoi

PS I take regular meds and no alternatives. I do not take thiamine.

kevowpd profile image
kevowpd in reply to Smittybear7

Parkinsonism is not a condition. That term is used to refer to symptoms that could be caused by PD or some other things:

mayoclinic.org/diseases-con...

PD is probably the cause of >90% of 'Parkinsonsisms'. The other causes in that list really aren't that common.

If you have inadequately treated PD (I.e PD that is impacting your QOL and is not treated by prescription medication or equivalent doses of levodopa from some other source), all these adjunctive remedies (like thiamine) are going to be a waste of your time, money, and good QOL years.

Smittybear7 profile image
Smittybear7 in reply to kevowpd

Thanks for your advice. I'm frustrated that no one offering a game plan for me to follow. Each specialist has his own agenda and there is little communication between them. I'm starting with OT andPT .PCP and neurologist in October, continue chiropractic treatment and get an opinion from a pain specialist. I am going to hold off on the nerve conduction test until I see my neurologist. I can't get in with my neurologist until October and don't want to have the PA start medication.

Smittybear7 profile image
Smittybear7 in reply to kevowpd

I am taking the B1. I'm starting up the dose to 1000 mg

This is very good news Dap! Thank you for sharing with the forum! Thiamine Mononitrate had been considered the " wrong form of Thiamine " for so long and now it is known that in some people, it may actually be more effective than Thiamine HCL!

I would like to add that forum member Lizzy9 had been giving her husband Thiamine HCL which was beneficial for symptom reduction, but when she switched him to Thiamine Mononitrate it was a significant improvement over the Thiamine HCL and she and her husband are quite happy about that!

Art

Dap1948 profile image
Dap1948 in reply to chartist

I must stress that when you take B1 sublingually, the thiamine mononitrate does not go through the digestion, but straight into the bloodstream. I would still be cautious about taking thiamine mononitrate orally.

chartist profile image
chartist in reply to Dap1948

Why is that?

Art

Dap1948 profile image
Dap1948 in reply to chartist

Apparently, mononitrate is stored in fat cells and builds up if it is taken orally. It may also accumulate in the kidneys and cause kidney stones if taken orally in large amounts. Hopefully this link will help...pediaa.com/difference-betwe...

LAJ12345 profile image
LAJ12345 in reply to Dap1948

I assume only a small amount actually is absorbed so most would be swallowed.

Dap1948 profile image
Dap1948 in reply to LAJ12345

The article talks of “the full amount of the medication reaching the bloodstream.” by this method. I aim not to swallow till it is absorbed.

LAJ12345 profile image
LAJ12345 in reply to Dap1948

Wow. Interesting.

Lizzy9 profile image
Lizzy9 in reply to Dap1948

Hello Dap ~ Yes, we are having very good outcome with the B1 mononitrate. My husband takes 25 mg twice a day with skipping 1 or 2 doses one day a week which brings his weekly dose to 300-350mg per week.

I just looked at the link you attached and it says:

“Thiamine mononitrate is used for the preparation of multivitamin formulations and as a food additive. It is used as a food additive because it is more stable and the water absorptivity is low (non-hygroscopic). It is safe to be used as a food additive or in multivitamin formulations because once it is dissolved in water, the nitrate ion is removed and only the thiamine can be absorbed.”

So I am wondering if we should crush them and mix and let it sit in a little water before taking? Any thoughts would be helpful.

We did try the sublingual and could not get the right dose.

Thank you for your help and information.

Have a fabulous day!!

Dap1948 profile image
Dap1948 in reply to Lizzy9

I’m pleased that you’re having success. I’m afraid I have no thoughts on whether you should mix it with water to remove the nitrate ion. It’s outside my knowledge or experience. I would say that if it’s working why change. It might not work as well. Your husband takes such a small amount. Hopefully someone might comment with more knowledge.

gaga1958 profile image
gaga1958 in reply to chartist

Is Thiamine Mononitrate only taken sublingually? Considering the delivery process, can it be effective as a swallowed pill too? Thx

chartist profile image
chartist in reply to gaga1958

gaga,

In my opinion , yes, but it will likely require significantly more TM to get the same effect as a relatively low dose of sublingual TM.

Art

Lizzy9 profile image
Lizzy9 in reply to chartist

Hi Art ~ I wonder if my husband is taking the mononitrate incorrectly since he is not taking it sublingually?Any thoughts?

Thank you ~ Gail

chartist profile image
chartist in reply to Lizzy9

If I remember correctly, he is still taking a relatively low dose of TM, well below 500 mg/day, albeit orally and he still saw significant improvement over Thiamine HCL once he switched to Thiamine Mononitrate which could mean that thiamine mononitrate is simply more effective than Thiamine HCL for PwP. There really are not many people who have tested TM on this forum other than you and Dap and Dap has never tested thiamine hcl, whereas your husband has tested both and you reported a significant improvement in his symptoms once he discontinued Thiamine HCL and started with Thiamine Mononitrate. The easiest way to find out if sublingual TM is the same as oral TM is to try it. The sublingual that Dap is using is this one and it comes in 100 mg fast dissolving tablets that are placed under the tongue to dissolve quickly. I take the same one, but I do not have PD, so I can not comment on that aspect of it as I am taking solely for the purpose of lowering my IL-17 levels which is also activated and elevated in PwP.

amazon.com/Superior-Source-...

Other suppliers sell this product for significantly less than Amazon sells it for, such as this one, making it fairly inexpensive :

evitamins.com/b1-superior-s...

Art

Dap1948 profile image
Dap1948 in reply to gaga1958

B1 mononitrate can be bought in an oral version but it can cause kidney stones in high doses

Lizzy9 profile image
Lizzy9 in reply to chartist

Hi Art ~ We are still very happy with the results from the B1 mononitrate and so grateful for your help. I have looked around a little tiny bit on the internet and some "people" say it is water soluble and others say it isn't. I'm going with that it is water soluble. My HWP is taking such a small dose that I don't think it is a thing to worry about.

I so appreciate all your help.

Have a fabulous day!!

Gail

(PS~I realize this thread is on the sublingual B1, but I'll mention real quick that we are having good outcome using 3 pills of DopaBoost in place of one of his C/L's!! When I have a few moments I'l find the thread we in which we were discussing this and give you a more information. Thank you!)

only '4' stars on amazon... everyone should check the reviews for themselves -- but thanks for posting

I’ve tried this one and it does taste nasty, but I am always amused that customers think the makers can take away the taste of a dissolving product. A molecule tastes like it tastes. If it tastes nasty anything that tastes different from the real thing is not the real thing, nice flavour or not!

Dap1948 profile image
Dap1948 in reply to LAJ12345

And everyone reports that you get used to it very quickly and it stops being unpleasant. Some things are just worth going through that stage which lasted five days for me

LAJ12345 profile image
LAJ12345 in reply to Dap1948

Yes, if they work it certainly is worth it. It’s just funny people think it can be made to taste sweet.

Yes they taste bitter, but if you take them properly, the taste is contained. Who knows what the reviewers on Amazon were taking them for!!!

Thanks daphne. Very good explanation of sublingual useage. I open my b1 capsules and place on my tongue- i may follow your explanation. I hv had alot of sucess with b1 too though hcl version. I may try monotriate

Thank youp

Dap1948 profile image
Dap1948 in reply to alaynedellow

Opening a capsule won’t make it behave like a sublingual and pass through the skin. It has to be made specially with tiny enough particles. Only try mononitrate if it’s sublingual, but if you’re having success with HCL, why change?!

alaynedellow profile image
alaynedellow in reply to Dap1948

True.

Can to much B1 make tremors,Dystonia and Rigidity worse ?? I’ve tried 1000mg and 500mg a day but those symptoms have gone worse pretty quickly for me 🤔🤔😞😞

I'm copying you exactly. I take it in the morning since I found it helpful to move my rytary toward evening to reduce restless leg. I think it's working for me too. So much better than all those pills. Thanks for your post!

hanifag profile image
hanifag in reply to pmmargo

Please tell me the brand name

pmmargo profile image
pmmargo in reply to hanifag

superior source microlingual B1 from amazon

Dap1948 thanks so much for the information! I am currently taking 2g of HDT and would live to reduce my suppliment count! I have definitely seen the benefits of the HDT, and will give yours a try when I run out of mine.

Dap1948 profile image
Dap1948 in reply to SAGoodman

I understand your feeling you’d like to reduce the number of capsules you swallow, however, it may be tricky to work out how much you need of sublingual B1 compared to the oral, HCL version. It will definitely be a lot less as none gets lost in the digestion. As you’ve already found success with HCL I’m tempted to say, why rock the boat! If you’ve got something that works why change?! On the other hand if you know how 2g of HCL feels, you would presumably know whether 100mg of sublingual made you feel the same. I would think you might feel more fatigue, for example, if it wasn’t enough. If you did feel this and wanted to try more than one sublingual tablet a day, I wouldn’t take them both at once. There is probably a limit to how much can be absorbed in one go. And I wouldn’t increase to two tablets every day straightaway, I’d take two one day and one the next etc and build up gradually.

Dap,

Hubby started

amazon.com/EZ-Melts-Thiamin....

The jury is still out there. :)

Thanks for sharing again your good results with B1 sublingual.

Dap1948 profile image
Dap1948 in reply to Despe

I don’t think that these are sublingual. I think they just melt and you swallow them. Does it say anywhere on the bottle The words sublingual or microlingual?? They are a very Low dosage to be going through the digestion. I would either put your husband on HCL tablets at a reasonable dose (500 mg) or buy the superior source sublingual B1. I’m not surprised that the jury is still out!

Despe profile image
Despe in reply to Dap1948

Yes, you are right. However, I believed the melting ones had the same effect. Guess I have to buy the liquid form.

He was on IM injections for more than a year while Dr. C. was still with us. After his passing, we have been experimenting with different doses and hubby seems to be doing OK at 100mg/d.

Dap1948 profile image
Dap1948 in reply to Despe

If he’s doing ok, stay on it! However, as it is going through the digestion it should really be HCL to protect the kidneys. Is it hydrochloride or mononitrate?

Despe profile image
Despe in reply to Dap1948

It's HCL, but still sublingual, places it under his tongue and melts within a few seconds.

Dap1948 profile image
Dap1948 in reply to Despe

Interestingly it says sublingual and hcl ONLY in the write up, not on the box. I’m still not sure about it being sublingual. My gut instinct says if it is flavoured it won’t absorb so well, that the flavours will block the thiamine’s absorption, but what do I know!

Despe profile image
Despe in reply to Dap1948

What box? It's not in a box. The one you are using has milk, stevia, and cherry flavor.

Dap1948 profile image
Dap1948 in reply to Despe

Tub then. It worries me that at one point on the blurb it says the product dissolves before it reaches the digestive tract. Sublingual tablets shouldn’t go anywhere near the digestive tract. It’s a lot more expensive! But hey, if you like the product And have success with it, then use it

in reply to Dap1948

I think you are correct that those are not sublingual. The manufacturer only mentions ease of dissolving for people with difficulty taking pills: solaralabs.com/products/fas...

GioCas profile image
GioCas in reply to

neither do they, it seems to me ...superiorsourcevitamins.com/...

in reply to GioCas

"Lingual" is part of the name. Oh! And in the description on that link: "Our Instant Dissolve MicroLingual® Tablets go to work fast,under the tongue."

GioCas profile image
GioCas in reply to

“…go to work fast,under the tongue”

all other brands too, (let's talk about b1) :-)

in reply to GioCas

Huh? Now I'm confused. There was some discussion that the one Despe linked to was not sublingual, so I showed that indeed the manufacturer website does not claim that it is sublingual. The other manufacturer being discussed (that you linked to) does claim that it is sublingual, and the name implies it by including the word "microlingual." Is this not a discussion about sublingual B1? If I've somehow gotten off-topic, I apologize.

eta: I see you've added the “…go to work fast,under the tongue”... the website you linked to also shows the directions are to use it sublingually or can be swallowed like a regular tablet. But the whole topic of what makes something sublingual is one that I have no expertise in. Some people are saying that it must be a specially designed particle that is small enough, otherwise it just winds up in the digestive tract. But, again, that is not something I know anything about. (so I'm only showing what the manufacturer's claim)

GioCas profile image
GioCas in reply to

no, no it's okay. MicroLingual® is a registered trademark. Thiamine mononitrate being fat-soluble is always absorbed by the sublingual mucosa. at this point, if the product mentioned by Despe is Thiamine mononitrate and it dissolves well in the mouth, it could have the same effects as the other, but it is not written what it is. Here is an article with a simple explanation of how a sublingual product works:

m.my-personaltrainer.it/far...

in reply to GioCas

Oh, I see. I just edited based on your edit. Glad to understand what you meant, thanks!

Despe profile image
Despe in reply to Dap1948

Are we talking about the same B1? You take walmart.com/ip/Superior-Sou...

and husband takes walmart.com/ip/EZ-Melts-Vit...

Active ingredients become readily available for absorption before entering the digestive tract. Great tasting formulas are available for popular ingredients across the spectrum of health categories.

Dap1948 profile image
Dap1948 in reply to Despe

Yes I take superior source. It should go straight through the skin to the bloodstream to be ‘sublingual'. It should not go through the digestive tract.

Despe profile image
Despe in reply to Dap1948

We are talking about the same thing, Dap. :)

Despe profile image
Despe in reply to Dap1948

Dap,

The link you provided refers to what exactly B1 hubby takes does.

WinnieThePoo profile image
WinnieThePoo in reply to Despe

It's not the same. Daphnes sublingual tablet is absorbed direct into the bloodstream and is therfore, more or less equivalent to the iv injection. The one your husband is taking is absorbed in the digestion like most B1 tablets people on this forum take.

Despe profile image
Despe in reply to WinnieThePoo

WTP,

Are we reading the same thing? :)

WinnieThePoo profile image
WinnieThePoo in reply to Despe

Yes. Apart from the really simple point of not saying sub-lingual

absorption before entering the digestive tract

Means "turned into something really easy to quickly digest before it gets to the place where it has to be digested and is digested"

It does not mean "is absorbed direct into the bloodstream before it gets to the digestion"

Effectively you have stopped giving your husband high dose Thiamin and given him regular low dose, deficiency correction Thiamine

And depending on how you interpret "the jury's out" it would appear that high dose B1 did little or nothing for him, given stopping it makes no difference.

GioCas profile image
GioCas in reply to WinnieThePoo

We can say that it is sublingual if it dissolves quickly in the mouth, it is a form of fat-soluble b1 (thiamine mononitrate or benfothiamine) and does not irritate the mucous membranes. I personally think that the nitrates produced by this form of B1 could give little unwanted effects and it is very different from B1 HCL. Thiamine always affects the central nervous system at any dose and form, promoting the production of energy at the cellular level that will improve fatigue. This is easy to check, just take a test.

WinnieThePoo profile image
WinnieThePoo in reply to GioCas

"Thiamine always affects the central nervous system at any dose and form",

So are you saying taking 25mg is the same as taking 4000mg? Orally.

How do you account for those who notice no differrence taking B1?

How do you translate Despe's comment that "the jury is out"?

GioCas profile image
GioCas in reply to WinnieThePoo

1) No, but if it is thiamine mononitrate it could be sufficient according to this post.

(Please don't attribute your conclusions to me, that's not fair, I always accept constructive criticism. :-) ).

2) Is this your case?

3) As you know I don't have a good understanding of English idioms, sorry, (if you help me I am grateful).

WinnieThePoo profile image
WinnieThePoo in reply to GioCas

Hi Gio

Don't worry too much

I don't think I have experienced an obvious, noticeable increase in energy taking thiamine (the answer usually then is that it can take up to 6 months to notice )

"The jury's out (deciding whether guilty or not guilty" means "I'm not sure", and in the context Despe used it probably meant "it doesn't seem to be working"

GioCas profile image
GioCas in reply to WinnieThePoo

damn WTP, you just did it again: you attributed a thought to Despe that maybe she doesn't have.

It is a scientifically acquired fact that thiamine contributes at an appropriate dose to increase cellular energy; athletes such as extreme mountain climbers always carry it with them for very difficult times, but they are well-fed trained people and do not use alcohol and drugs while climbing.

I quote the first post taken at random on Google: “Vitamin B1 contributes to the carrying out of the important process of converting glucose into energy. Like vitamin B2, vitamin B1, or Thiamine, has the role of synthesizing the energy processes of the organism, releasing the latter the energy necessary to carry out daily activities. ".

It is not the only aspect, but for this it will take half an hour to see it, if you live healthy and the thiamine is good… emh i.e. more bitter than ever.

😜

Despe profile image
Despe in reply to WinnieThePoo

I never wrote he takes 25mg. He takes 4 of those am and 4 pm, total 200mg/d.

WinnieThePoo profile image
WinnieThePoo in reply to Despe

Thank you for clarifying. Are they working? What benefits does he get from the B1 he takes?

GioCas profile image
GioCas in reply to WinnieThePoo

Wtp

Despe has written all his story many times, the last 20 days ago, but you still don't know it?

Once more nothing will change.

WinnieThePoo profile image
WinnieThePoo in reply to GioCas

Save me looking it up gio

Same questions

GioCas profile image
GioCas in reply to WinnieThePoo

🙄

WinnieThePoo profile image
WinnieThePoo in reply to GioCas

Stop playing the geisha Gio. This is a forum for sharing information and I asked straightforward questions of Despe

GioCas profile image
GioCas in reply to WinnieThePoo

If you do not want others to intervene I recommend that you use private messages. 😜

WinnieThePoo profile image
WinnieThePoo in reply to GioCas

It's a forum Gio. And not owned by you. Just mind your own business and confine any contributions to constructive ones

GioCas profile image
GioCas in reply to WinnieThePoo

Wtp , trying to silence others like you are trying to do with me right now doesn't seem very constructive.

WinnieThePoo profile image
WinnieThePoo in reply to GioCas

Grow up

GioCas profile image
GioCas in reply to WinnieThePoo

Winnie the Poo,

Sure, but you stop watching cartoons from 100 years ago. With an avatar like yours you can't give lessons about growing up.. 😁

WinnieThePoo profile image
WinnieThePoo in reply to GioCas

I appreciate you have latin blood but if you must play the prima donna, learn to sing a top C.

Despe profile image
Despe in reply to GioCas

Thanks, Gio. :) He did restart Niacin, he feels better when he takes it, just that he doesn't like the flushing.

Despe profile image
Despe in reply to WinnieThePoo

More benefits than Sinemet! :)

WinnieThePoo profile image
WinnieThePoo in reply to Despe

So it doesn't work at all. Why else would you be so evasive? People with nothing to hide give straight answersFair enough, it doesn't help your husband in any way (although that's the fault of his personality)

Despe profile image
Despe in reply to WinnieThePoo

Lets agree that we disagree, WTP. I interpret it differently, plus HCL doesn't affect kidneys or liver.

There’s always one (again)

I take generic sinemet first thing in the morning with water. How long after that would you recommend I take the sublingual?

Dap1948 profile image
Dap1948 in reply to AmmieM

Mmmmm... my feeling is that you merely wait 10 minutes to get the water out of your mouth. The main thing is not to have toothpaste or food in your mouth beforehand which would hamper absorption

I take my 50/200 Sinemet sublingual. I swallow B1 and Mucuna Purines

Dap1948 profile image
Dap1948 in reply to Coot18

Do they make a version of Sinemet which works sublingually and passes through the skin into the bloodstream?

The link you posted Daffers says none available 😕🤔

Dap1948 profile image
Dap1948 in reply to jeeves19

They’re always going out of stock which is one of the problems with them. Guess I’ve caused a run on them!

Thank you so much for sharing!

When you say you don't swallow it, how long is that for? I'm trying it and it's well & truly dissolved in my mouth (and not so bad a taste either imo). But how long do you wait before you swallow it? Thanks

Dap1948 profile image
Dap1948 in reply to stuartj

It dissolves quite quickly but it takes time for the melted tablet to pass through the skin into the bloodstream. Half an hour is the recommended wait time...compoundingrxusa.com/blog/c...

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