As many of you know, I have had a lot of success with the sublingual version of B1. I started taking it in 2017 and after a few months realised my slowness, my fatigue and my rigidity had all gone. I was diagnosed eleven years ago and since taking B1 have not increased my medication which remains at just 200 mg ldopa per day. Yesterday I came across this very good article on how to take sublingual tablets.
Sublingual B1 is thiamine monoitrate and I'm aware that thiamine hydrochloride (HCL) is the preferred form of B1 for oral administration. There has been talk of monoitrate being bad for the kidneys. I checked this out with Dr Lonsdale, a world authority on thiamine and he said "no" the sublingual B1, being monoitrate, is no danger to the kidneys. A sublingual tablet, if taken correctly, goes straight through the skin and into the bloodstream. Because it is so efficient you need far less of it than if you were taking the oral version. I started in 2017 on 1x 100 mg tablet a day and gradually reduced this over time, and now take just four tablets a WEEK.
Because someone will ask, I get the sublingual B1 from -
It is very cheap!
It does taste rather bitter but if you keep it firmly under your tongue while it dissolves it's not too bad and you do get used to it in a week or so. Do follow the instructions as to how to take it though. It won't work otherwise.
A doctor friend told me that all tablets would be sublingual if it was possible to make them into tiny enough particles to pass through the skin, as it was a much more efficient way of administration. Perhaps that's why they are monoitrate. Perhaps the hcl version can't be made into small enough particles. I'm just guessing. The main thing is that sublingual tablets can be monoitrate!
I hope this information is helpful.
Very interesting. Do you know if sublingual levodopa exists?
I’m pretty sure we would be prescribed it if it did. One of the many things whose particles are too large I guess!
It's possible. Thanks
Hi Dap, Do you think the effects of levodopa would dissipate if taken in crushed form sublingually?
It would only work like a sublingual tablet if it was produced as one with tiny enough particles to pass through the skin. Not many substances are able to be compounded into sublingual versions.
It is my understanding that Levodopa always (and only) enters the blood through the small intestine.
If you crush a regular c/l tablet and put the resulting powder under your tongue, nothing will happen until you swallow it with some liquid and it makes its way to the small intestine.
Note if you crush a regular c/l tablet and stir it into some water then drink it OR crush it with your teeth and then wash it down with some liquid, it will take effect quicker, then a solid tablet, but will not last as long (smaller Tpeak and Thalf).
Lastly there is a c/l ODT tablet (orally disintegrating tablet) formulation, but it is meant for people are unable to swallow a regular tablet, and again it does not do anything until it reaches your small intestine...
Perfect Levod, thanks.
There is melevodopa that dissolves in water and has a rapid effect, in the trade name in Italy is Sirio.
Hi Gio' thank you, the product is interesting, I had never heard of it. Are you using it? Do you think it is preferable to Sinemet?
I Never used but prescribed to me, according to my neurologist it is complementary to the c / L that is a small immediate additional dose for difficult moments because it is very fast, Max three a day.
Great information as always Gio'.
I think it is interesting if you want to go on faster than crushed regular c/l in water (which starts to take effect in about 20 minutes), and don't care how long it lasts (it won't last as long as crushed regular c/l in water does).
I don't know how it is actually dispensed (e.g., as an effervescent tablet or powder), but it may save you the trouble of breaking out the mortar and pestle or chewing regular c/l tablets.
Thanks again Levod.