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Sometimes ignorance is bliss

Gcf51 profile image
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Sometimes ignorance is bliss; Probiotic “Lactobacillus plantarum 299v”(a) is supposed to increase iron absorption,    park_bear “...I always thought PWP have too much iron in their brains”. — I probably wouldn’t have tried if I remembered that (there are articles on the internet that agree(b) — at least one indicates dysfunctional iron utilization(c). I am not a strong reader or understander of medical jargon).

Day 12 of B1 break, Day 8 of 229v:

- I would recommend “Lactobacillus plantarum 299v”, if for no other reason than Mood Enhancement(d).

- Parkinson’s — I don’t remember a time (since being diagnosed) that I have had less symptoms. (Disclaimer: Last night I was up past my bedtime, I got sleepy and had balance issues for a few hours. This morning back to: I don’t remember a time (since being diagnosed) that I have had less symptoms — pretty well none.)

- I still have numb feet, my feet hurt with shoes on, I get up and walk it off; it seems to be getting better with each step I take — I speculate nerves are still healing from accumulation of unutilized iron.

- 3 days ago, I accidentally missed my midday dose of C/L with no “Off” (return of symptoms). So now I am only taking (1-1/2) 3 times a day (25% reduction in dose). You are not supposed to stop cold-turkey, but I wonder if that just applies to nonfunctioning neurons and I am praying that my hibernating ones have been woken up. (Are the hibernating neurons just in the brain or there they in the rest of the nervous system too?)

- I doubt if it’s the B1 break.

- I ended my last break at day 6 when my bad neck became unbearable (neck pain has not been a problem this time).

- Is it due to a single strain probiotic overpowering some harmful ones?

- I still occasionally have some tremor, but I am excited.

- Would this have happened if I hadn’t found success with High Dose Thiamine (HDT) a year ago?

- Should I end the B1 break?

- The box says supports regularity (I am having BMs, but not as regular as I was having with B1).

- Sleep: I am back to my normal 6 to 7 hours of sleep with B1 I had as much as 10 hours of bedtime, (4 hour of interrupted sleep and then up for restroom every 50 minutes. With 229v, I am unable to go back to sleep.)

- It could still be placebo? With the good Lord willing, I will accept what He wills. PTL.

(a) healthunlocked.com/cure-par...

(b) The reason iron is suspected is; iron is one of the metals found in autopsies of deceased PD patents’ brains.

(c) Link is on Traumatic brain injury (TBI), but TBI is suspected as a cause of PD and maybe the cause of mine. ncbi.nlm.nih.gov/pmc/articl...

(3) “conclusion, Lp299v, together with 20 mg of iron, could result in a more substantial and rapid improvement in iron status and improved vigor compared to 20 mg of iron alone.” pubmed.ncbi.nlm.nih.gov/323...

Notes:

1) I have downloaded the Booklet from the following linked site. Interesting reading. [Benefits: Irritable Bowel Syndrome, Inflammatory Bowel Disease, Gastrointestinal infections, Iron absorption, Other (Gut-Brain Axis, Metabolic Health)]

“A disturbed GI microbial balance and decreased bacterial diversity have been coupled to mental health in several conditions (such as Parkinson’s, Alzheimer’s, major depression, autism spectrum disorders).”

probi.com/solutions/lp299v-...

2) I am taking (1) twice a day. “The Booklet says It has been re-isolated more than ten days after administration ceased.”, so less often should be sufficient.

3) The key may be leaky gut and less toxins in my blood stream — and iron has nothing to do with it.

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Gcf51
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14 Replies
Bolt_Upright profile image
Bolt_Upright

Thank you for the detailed post!

I did not understand this: "With 229v I can’t go back to sleep."

Are you saying with 229v you can't get back to sleep if you get up to use the bathroom?

Gcf51 profile image
Gcf51 in reply toBolt_Upright

Right

Bolt_Upright profile image
Bolt_Upright in reply toGcf51

Thanks!

Gcf51 profile image
Gcf51

My restless leg has only been occasionally -- I haven’t had reoccurrences since starting taking 299v.

healthunlocked.com/cure-par...

Romulus13 profile image
Romulus13

I can't seem to find a way to order this on the web page you linked. Is this where you are buying it from (probi.com/solutions/...)?

Gcf51 profile image
Gcf51

I am using amazon.com/gp/product/B00O4...

Romulus13

JayPwP profile image
JayPwP

Here's the article

academic.oup.com/brain/arti...

Gcf51 profile image
Gcf51 in reply toJayPwP

I am not saying the arguments in the article are not valid. But, they are attempts to explain why iron is accumulated in the tingles of PD brains. One can argue that people with yellow fingers get lung cancer (someone told me this as a joke), when in fact they have yellow fingers because they smoke and get lung cancer because they smoke. I am not anemic trying to increase my RBC; I am not taking iron supplementation, and I will have my iron levels tested, but if tested high, I could argue it is because iron is high because iron is being unaccumulated (dissolved) elsewhere.

PD has not been cured yet, and it is entirely possible it is because of wrong assumptions.

JayPwP profile image
JayPwP in reply toGcf51

I agree. Till causation is established, everything is speculation.

JayPwP profile image
JayPwP in reply toGcf51

I am not for or against the article. I just put it there because I thought you were looking for it

Gcf51 profile image
Gcf51 in reply toJayPwP

I would like to know, but I will enjoy this bliss of my N-of-1* trial for as long as it last.

* N-of-1 trials in clinical medicine are multiple crossover trials, usually randomized and often blinded, conducted in a single patient (my N-of-1 trial is self instead of clinical). effectivehealthcare.ahrq.go....

JayPwP profile image
JayPwP in reply toGcf51

👍👍👍

Gcf51 profile image
Gcf51

Rereading my post, I need to emphasize that numb feet and shoes hurting feet are nothing new. Improvements seem to be nothing more than by imagination.

also, I chatted with someone about HDT. They indicated that they once took a B1 break for 2 months and the only symptom that returned was fatigue. As of today, I have only been on B1 break for 2 weeks. Time will tell.

Gcf51 profile image
Gcf51

Now I know why my shoes were loose. healthunlocked.com/cure-par...

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