Mitochondria, sugar, red lights and Doxazosin

[WinnieThePoo]

My scientist friend, who is working on a vibrotactile coordinated reset prototype for me, drew my attention to an article in New Scientist - which is very interesting

newscientist.com/article/mg...

Quick take aways

Mitochondria - in deep evolutionary history , they are thought to have existed as independent life forms, before entering bacteria . Mitochondrias ability to generate energy aided the evolution of multicellular organisms (that includes us guys)

Mitochondrial function needs glucose which is part of the cellular respiration equation - producing ATP - and hence cellular energy

Doxazosin (Terrazosin) may help PD by improving mitochondrial function by binding to an enzyme called PGK1 that is involved in breaking down glucose and producing ATP. Research at the University of Iowa has found that the longer people are on these drugs, the lower the risk (of PD). I've been taking Doxazosin for 3 years.

Erythropoieten is another possible candidate for mitochondrial boosting

There is a lot of research going on - including mitochondrial transplants

Not mentioned in this article, but clearly relevant, is the idea that mitochondria are boosted by red light therapy and can migrate around the body.

mdpi.com/1422-0067/23/24/15734 among many

[Bolt_Upright]

Very cool news on the vibrotactile coordinated reset prototype! Are you getting this one? youtu.be/1PfsVjnPAuQ(Not working as expected?)

[WinnieThePoo in reply to Bolt_Upright]

No. He is building something with some metal dome tweeters he has in the loft

[Bolt_Upright]

I appreciate this point: "Mitochondrial function needs glucose"

Pepsi (with Real Sugar)

[Bolt_Upright in reply to Bolt_Upright]

But... High glucose induces mitochondrial dysfunction independently of protein O-GlcNAcylation ncbi.nlm.nih.gov/pmc/articl...

[WinnieThePoo in reply to Bolt_Upright]

We run on glucose. Doesn't mean we need to overeat refined sugar.But remember

C6H12O6 + 6O2 → 6CO2 + 6H2O.

[Bolt_Upright in reply to WinnieThePoo]

6CO2 + 6H2O + light ----> C6H12O6 + 6O2

Carbon dioxide, water, and light are used to make glucose and oxygen. In plants, photosynthesis usually occurs in the leaves.

Since I don't have leaves, I guess I will stick with Pepsi (with real sugar).

(seriously, I should switch to only raw honey)

[JayPwP in reply to Bolt_Upright]

Then why are ketones beneficial to mitochondria?

[WinnieThePoo in reply to JayPwP]

ketones are another way of running mitochondria - but they were built to run on glucose. That doesn't necessarily mean that the original design brief is best. We were built to grow old and die. Ageing is a natural phenomena.

but the design spec was to run on sugar!

[WinnieThePoo]

Undoubtedly honey is better than Pepsi. But whether from photosynthesis or honey, we give back to the plants, courtesy of the mitochondria making energy with cellular respiration

C6H12O6 + 6O2 → 6CO2 + 6H2O

[WinnieThePoo]

This is GCSE biology stuff

flexbooks.ck12.org/cbook/ck...