Tudca and Phosphatidylcholine (PC) consideration

[ewebhook]

Was talking to my health coach about these and she just had a speaker talk about it. Here's part of the transcript she provided me. It clarifies the difference between PC and choline a bit.

I. TUDCA of Taking TUDCA

• Supports Endoplasmic Reticulum (ER) Function:

• TUDCA helps reduce stress on the endoplasmic reticulum, which can be particularly beneficial for individuals experiencing ER stress-related conditions.

• Chaperone Activity:

• TUDCA has chaperone activity, aiding in the breakdown of misfolded proteins and lipids. This can be helpful for maintaining cellular homeostasis and preventing the accumulation of dysfunctional proteins.

• Improves Bile Flow:

• TUDCA increases bile flow, which can aid in digestion and the elimination of toxins. This is beneficial for individuals transitioning to a diet higher in fats and proteins or those with impaired bile production.

• Neuroprotective Effects:

• TUDCA has been studied for its neuroprotective effects, making it a potential supportive treatment for neurodegenerative diseases such as Parkinson's and ALS (Amyotrophic Lateral Sclerosis).

Individuals Who Might Benefit from TUDCA

• Those with Neurodegenerative Diseases:

• Individuals with conditions such as Parkinson's disease, ALS, or other neurodegenerative disorders may benefit from TUDCA due to its neuroprotective properties.

• People with Poor Fat Digestion:

• Those transitioning to a higher-fat diet or experiencing difficulties with fat digestion can benefit from TUDCA's ability to enhance bile flow and improve fat digestion.

• Individuals with ER Stress:

• People experiencing endoplasmic reticulum stress or conditions related to protein misfolding can benefit from TUDCA's chaperone activity.

• Those Undergoing Detox Protocols:

• While mentioned not using binders or traditional detox protocols, TUDCA can still support the body's natural detoxification processes by improving bile flow and aiding in the removal of intracellular toxins.

• Individuals with Mitochondrial Dysfunction:

• Those with mitochondrial dysfunction might benefit from TUDCA due to its overall support for cellular health and mitochondrial function.

Usage Recommendations

• After Meals:

• TUDCA is typically taken after meals to aid in fat digestion and to support bile flow.

• Before Bed (for Neurological Conditions):

• For those with neurological conditions, taking TUDCA before bed can help maintain blood levels overnight, supporting continuous neuroprotection.

TUDCA Long-term Use Considerations

• Caution with Long-term Use:

• Speaker mentioned concerns about using TUDCA long-term due to potential imbalances in bile acids and the risk of producing toxic metabolites. Therefore, it is important to take breaks from TUDCA use periodically and not to rely on it indefinitely.

II. Phosphatidylcholine (PC)

Phosphatidylcholine is a crucial component of our cell membranes and is involved in numerous cellular functions, including energy production and redox balance. ..learned from yesterday's workshop which emphasized that PC is essential for maintaining the structure and function of cell membranes, especially in mitochondria, which are the powerhouses of our cells.

Key Points from the Transcript

• PC is vital for maintaining the structure and function of cell membranes and mitochondrial membranes.

• It helps in the natural detoxification process, supports redox potential, and provides essential nutrients to the cells.

• PC is not just a temporary supplement but an essential nutrient necessary for ongoing cellular health and detoxification processes.

Phosphatidylcholine (PC) offers numerous benefits, especially related to cellular health, mitochondrial function, and overall wellness. Here are the key benefits and the types of individuals who might benefit from taking Phosphatidylcholine:

Benefits of Taking Phosphatidylcholine (PC)

• Supports Cellular Membrane Structure:

• PC is a major component of cell membranes and helps maintain the integrity and fluidity of cellular membranes, which is crucial for optimal cellular function.

• Enhances Mitochondrial Function:

• PC supports the structure and function of mitochondrial membranes, crucial for energy production and overall mitochondrial health.

• Aids in Detoxification:

• PC helps in detoxification by supporting bile production and flow, which aids in the elimination of toxins from the body.

• Reduces Inflammation:

• By maintaining healthy cell membranes and supporting mitochondrial function, PC can help reduce systemic inflammation.

• Supports Neurotransmitter Function:

• PC is a precursor to acetylcholine, a neurotransmitter important for memory and cognitive function.

• Improves Liver Health:

• PC supports liver function and helps in the regeneration of liver cells, making it beneficial for liver health.

• Enhances Redox Potential:

• PC helps improve the redox potential by maintaining cellular membrane integrity and supporting the balance of reactive oxygen species (ROS) and antioxidants.

Individuals Who Might Benefit from Phosphatidylcholine

• Those with Mitochondrial Dysfunction:

• Individuals experiencing mitochondrial dysfunction or related diseases can benefit from PC due to its role in supporting mitochondrial membranes and energy production.

• People Undergoing Detox Protocols:

• PC aids in detoxification processes, making it beneficial for individuals undergoing detox protocols or needing support for toxin elimination.

• Individuals with Liver Conditions:

• Those with liver conditions, such as fatty liver disease or those recovering from liver damage, can benefit from PC's liver-supportive properties.

• People with Cognitive Decline:

• PC is beneficial for those experiencing cognitive decline or looking to support brain health due to its role as a precursor to acetylcholine.

• Individuals with Inflammatory Conditions:

• Those with chronic inflammatory conditions may benefit from PC's ability to support cell membrane health and reduce systemic inflammation.

• Athletes and Active Individuals:

• Athletes or those engaging in regular physical activity can benefit from PC due to its role in maintaining cellular health and supporting recovery processes.

Usage Recommendations

• Regular Supplementation:

• PC can be taken regularly as part of a supplement regimen to support overall cellular and mitochondrial health.

• With Meals:

• Taking PC with meals can help support digestion and the absorption of dietary fats.

Long-term Use Considerations

• Continuous Use:

• Unlike TUDCA, PC is considered an essential nutrient and can be taken continuously to maintain cellular health. It is not typically associated with adverse effects when used long-term.

.......There was a discussion about concerns related to choline and TMAO, but it was clarified that phosphatidylcholine (specifically in the form of PC oil) does not have the same effect as free choline, which can raise TMAO levels. TMAO levels have not been conclusively linked to adverse cardiovascular effects, and the form of PC used in supplements like BodyBio’s is absorbed efficiently without significantly affecting lipid profiles.

Key Points from the Transcript

• PC is vital for maintaining the structure and function of cell membranes and mitochondrial membranes.

• It helps in the natural detoxification process, supports redox potential, and provides essential nutrients to the cells.

• PC is not just a temporary supplement but an essential nutrient necessary for ongoing cellular health and detoxification processes.

[Mezmerric]

excellent post. Many thanks.

[Bracondale]

Thank you, excellent information.

[park_bear]

"There was a discussion about concerns related to choline and TMAO, but it was clarified that phosphatidylcholine (specifically in the form of PC oil) does not have the same effect as free choline, which can raise TMAO levels. TMAO levels have not been conclusively linked to adverse cardiovascular effects"

The foregoing is a feel good fantasy. The TMA/ TMAO problem is very real and I have personally experienced it with PC. If you're going to supplement you should also take berberine at the same time to suppress the formation of TMA by gut bacteria.

[ewebhook in reply to park_bear]

That's what I needed to hear park_bear! How would one know if TMA is an issue for them.

[park_bear in reply to ewebhook]

There is a blood test for TMAO which is a marker for TMA

[ewebhook in reply to park_bear]

Just wondering what type of diet would you eat considering potential TMAO elevation with meat, eggs, dairy, saturated fats,etc.

[park_bear in reply to ewebhook]

In my experience choline supplementation is a problem because it creates a concentrated island of choline in the gut. I do eat a single egg for breakfast, in combination with other food ingredients, from time to time. As far as I know that's not caused any problem. I stay away from red meat and dairy for other reasons. Bear diet: nuts, berries and salmon.

[ewebhook in reply to park_bear]

Love that response. So appropo!

[Wellnesslover]

very helpful!