Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure. Thiamine HDT significance.

[aspergerian13]

Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure. Thiamine HDT significance.

2013.

Excerpts:

Mitochondria have a very active social life style involving frequent fusion and fission events. Mitochondria that lose their ability to properly respire become excluded from the networking population and will be consumed by the cellular equivalent of a lion, the autophagosome. This forms a pathway of quality control.

However, recent studies suggest that arrest of mitochondrial fusion at the cellular level, also termed “fragmentation”, is playing a role in the adaptation to excess nutrient environment. Recognizing that excess nutrient environment places mitochondria in a biological conflict of interest may help understanding the link between metabolic and aging associated conditions.

While aging involves insufficiency of mitochondrial quality control and turnover mechanisms (such as autophagy), diabetes and obesity are influenced by the ability of the organism to deal with excess nutrient environment.

The observation that both conditions are impacted by the duration of exposure to excess nutrient environment raises the question: Are the tasks of handling nutrients in excess and maintaining quality control ever in conflict?

In this review, we discuss evidence to support a hypothesis that adaptation to excess nutrient environment interferes with quality control functions and, as a result, affects mitochondrial function in a magnitude that reflects the duration to which the organism was exposed to excess nutrient environment.

[aspergerian]

The link.

ncbi.nlm.nih.gov/pmc/articl...

[aspergerian in reply to aspergerian]

617 cite Liesa 2013: Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure.

scholar.google.com/scholar?...

[aspergerian]

If Magtein (M threonate) enters brain and csf of a person who has suboptimal mitochondrial function,

then additional mitochondrial nutrients may be helpful.

Activity influences mitochondria nutrients requirements

Mitochondria—Fundamental to Life and Health.

2014. Pizzorno.

ncbi.nlm.nih.gov/pmc/articl...

The Role of Nutrients in Protecting Mitochondrial Function and Neurotransmitter Signaling: Implications for the Treatment of Depression, PTSD, and Suicidal Behaviors.

2016.

ncbi.nlm.nih.gov/pmc/articl...

Mitochondrion at the Crossroad Between Nutrients and Epigenome.

2019.

ncbi.nlm.nih.gov/pmc/articl...

[KERRINGTON in reply to aspergerian]

So mitochondrial nutrients like acetyl l carnitine, alpha lipoid acid, vitamin E, coq 10, & C, would be good to take ?

[aspergerian13 in reply to KERRINGTON]

My hunch is yes, in moderation.

[MarionP in reply to aspergerian13]

Whoa, that's like leaping a fell. Though I might consider them for other reasons, this is not evidence supporting supplements. Interesting basic references for academic reading but still very very basic. Expect no guarantees from the management, free advice may be worth the price.

As the saying goes, "You first."

You know who knows about mitochondria, sharoncrayn. Enough to induce me to give up LaPhroaig, no easy thing.

[aspergerian in reply to MarionP]

Note the precise scientific term "hunch". Also note:

α-Tocopherol incorporation in mitochondria and microsomes upon supranutritional vitamin E supplementation.

ncbi.nlm.nih.gov/pmc/articl...

[Vegegardner in reply to KERRINGTON]

How much of each and how often ? All mixed together ??? Thankyou. We have alc ALA etc. Can NAC go with it?