"Farnesol, a natural compound of some herbs and fruits in commercial use, was seen to protect nerve cells in the brain and possibly restore some of these cells to health in multiple mouse models of Parkinson’s disease."
“Our experiments showed that farnesol both significantly prevented the loss of dopamine neurons and reversed behavioral deficits in mice, indicating its promise as a potential drug treatment to prevent Parkinson’s disease,” Ted Dawson, MD, PhD, director of the Johns Hopkins Institute for Cell Engineering and one of the study’s lead authors, said in a press release."
The information above is from this first, 2021 research article.
A few years ago, I searched for farnesol. I brought some and the bottle listed ingredients indicated more preservative than farnesol. I wonder how much preservative is in this.
wow -- your reply was a real EYE OPENER for me! I have a bottle of this stuff right in front of me that I have used several times in my diffuser. So to reply to your question I just grabbed the bottle and read the 'WARNING LABEL' on the back which specifically tells me NOT to use it the way I've been using it!!! It's so bad that now I have to call the company to make further inquiries as I thought this was a very safe to use essential oil. I'll update here later... and thanks again!
i'll update as soon as i call the company -- my guess is that they will tell me not to use it in its 'pure form' -- but only as an ingredient along with others
In Canada, farnesol is classified as a natural health product and is regulated by Health Canada. In Australia, it is classified as a complementary medicine and is regulated by the Therapeutic Goods Administration (TGA).
If you opt to go with a cool mist humidifier, be sure to use distilled water. I noticed an oddity last year when I was using a cool mist humidifier with tap water. The flame on the gas range would be yellow and orange instead of blue all day following overnight use. The humidifier was running upstairs in the bedroom well away from the kitchen. A quick search revealed the cause. The cool mist units expel all the minerals in the water into the air and react with the flame. Due to our likely sensitivity to minerals, e.g. manganese, it's best to avoid this. Rather than deal with the recurring cost of distilled water, I decided to go with a warm mist humidifier. I'm very satisfied with my new unit, and my gas range burns blue again.
One crazy thought. If it proves to be safe to breathe the farnesol oil, you could always try using a plug-in air freshener. I pop the cap off emptied refills, put Lavendar oil in them, and snap the cap back on.
"If you use a humidifier, be sure to keep it clean to prevent mineral buildup and the growth of bacteria and molds. Humidifiers that hold standing water, particularly cool-mist humidifiers, can disperse these materials into the air. Warm-mist humidifiers generally disperse less, if any, of these materials into the air."
"Emptying the tank and drying all surfaces of the humidifier daily is one way to safely keep it clean. Also, consider refilling the tank with bottled water labeled "distilled" or "purified," which has a lower mineral content than most tap water."
just wanted to confirm something with you since you just saved my health (I just canceled my Amazon delivery of a "cool mist" humidifier ... My other post had advice from mayo clinic about humidifiers and recommended "distilled" water (which gets pretty expensive if I'm using this humidifier daily) .... You said that with your "warm mist" humidifier you use "tap" water... is that correct? and you feel OK with that if you do?
Yes, I use tap water in my warm mist humidifier and feel confident it's not dispersing impurities into the air. It still needs cleaning every 4-5 days to remove residue.
This is the one I purchased. Unfortunately, it's currently out of stock. It does have a tray for essential oils.
11.28.22 -- I just spent a couple of hours online and I called '2' companies that sell Farnesol. Neither of them recommended Farnesol for therapeutic use -- but only for commercial or industrial application. I'm very confused because I bought a bottle of this stuff at.... Amazon! .... And I have used it at least a dozen times without suffering any ill (or 'PD helpful') effects. But for now, I'll err on the 'safe side' and not use it anymore. Too bad... because simply "breathing in" a remedy is so appealing to all of us... Another 'rabbit hole'... i guess...
believe me or not, I even drink a few bottle mixed with water. i bought it here: naturallythinking.com/farnesol,, no significant effect, then I stopped. i think breathing-in is fine. will try, I still have 2 bottles 50ml..
well... if you read my post... today i spoke to two manufacturers of farnesol and both said a resound 'No!' to anything except commercial and industrial use of farnesol
FYI - doTerra via email said: (approximately 1 yr ago.)
Thank you for your question! Farnesol is a group of sesquiterpene alcohol isomers—(E,E)-farnesol, (E,Z)-farnesol, (E)-beta-farnesol—that may be found in some essential oils like sandalwood (Santalum spicatum), neroli, niaouli, cananga, rose, yarrow, and magnolia. When it is present, it is typically found in lower amounts. It may be present in the aforementioned doTERRA essential oils.
I just got this email reply from a well-know company that manufactures high quality essential oils:
------------------------------
Hello,
Thank you for your question! Farnesol is a group of sesquiterpene alcohol isomers—(E,E)-farnesol, (E,Z)-farnesol, (E)-beta-farnesol—that may be found in some essential oils like sandalwood (Santalum spicatum), neroli, niaouli, cananga, rose, yarrow, and magnolia. When it is present, it is typically found in lower amounts. It may be present in the aforementioned doTERRA essential oils.
Please let us know if we can help you with anything else.
i'm not officially dx'd ... my neuro/MDS is a big dummy ... i have multiple "parkinson-like" symptoms (internal tremors, vision / eyelid tremors, left face numbing, constipation, feet and lower leg cramps) ... NONE (thank God) ... except for the constipation which I think I finally have under control ... are affecting my life... and ... they are not getting worse... my first symptom started on June 20, 2021 with my left thumb visibly tremoring for a few seconds ...
now ... i rarely, rarely, have any limb movement ... I'm taking about 40 supplements daily and i'm on an O.M.A.D. diet -- today is day #386! ... (one meal a deal with all calories eaten within a 2 hour window). I ignored the doctor's request for a DatScan and blood work because he completely ignored MY mountains of data that I had prepared for him (also a 2 page summary). ... So as for 'farnesol' ... i gave up on that when I heard about the negative effects from the companies that SOLD it. It is for 'perfume products'.... NOT... for PD therapy... Best of luck to you
I was interested in your discussion on using Farnesol in a humidifier and thought it might be possible to get Farnesol in vape form. I came up with this article about Farnesol (Green Apple Flavour) being used to stimulate reward behavior in vape users. It states:
"Our electrophysiological assays with male mice revealed that farnesol treatment increases ventral tegmental area (VTA) dopamine neuron firing frequency and this may be due to a decrease in inhibitory tone from GABA neurons"
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