Breathing issues and Parkinson's Disease - Cure Parkinson's

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Breathing issues and Parkinson's Disease

beehive23 profile image

Knowledge is power ....learn about your disease.

Shortness of breath, a 'wearing-off' symptom in Parkinson's disease.

Khan W, Naz S, Rana AQ.

Clin Drug Investig. 2009;29(10):689-91. doi: 10.2165/11315290-000000000-00000.

PMID: 19715385

Respiratory function in Parkinson's disease.

Shill H, Stacy M.

Clin Neurosci. 1998;5(2):131-5.

PMID: 10785839 Review.

Upper airway muscles dysfunction and levodopa responsiveness in Parkinson's disease.

Brescia Morra V, Polverino M, De Luca G, Landi P, Galdi A, Campanella G.

Acta Neurol (Napoli). 1992 Aug-Dec;14(4-6):512-8.

PMID: 1293993

Respiratory dysfunction in Parkinson's disease.

Brown LK.

Clin Chest Med. 1994 Dec;15(4):715-27.

PMID: 7867286 Review.

Obstructive and restrictive pulmonary dysfunction increases disability in Parkinson disease.

Sabaté M, Rodríguez M, Méndez E, Enríquez E, González I.

Arch Phys Med Rehabil. 1996 Jan;77(1):29-34. doi: 10.1016/s0003-9993(96)90216-6.

PMID: 8554470

15 Replies

Here's a review just published last month:

ncbi.nlm.nih.gov/pmc/articl...

"The presence of respiratory symptoms in Parkinson's disease (PD) has

been known since the first description of the disease, even though the

prevalence and incidence of these disturbances are not well defined.

Several causes have been reported, comprising obstructive and

restrictive pulmonary disease and changes in the central ventilatory

control, and different pathogenetic mechanisms have been postulated

accordingly. In our review, we encompass the current knowledge about

respiratory abnormalities in PD, as well as the impact of

anti-Parkinsonian drugs as either risk or protective factors. A

description of putative pathogenetic mechanisms is also provided, and

possible treatments are discussed, focusing on the importance of

recognising and treating respiratory symptoms as a key manifestation of

the disease itself. A brief description of respiratory dysfunctions in

atypical Parkinsonism, especially α-synucleinopathies, is also provided."

It's a good review, but I don't think it goes far enough - I don't think the authors have fully explored all the possible mechanisms involved in respiratory dysfunction in PD. OTOH, I am gratified to see they drew parallels between NMLS and NMS:

" a significant reduction of anti-Parkinsonian drugs are risk factors for

the so-called neuroleptic malignant-like syndrome (NMLS), a rare but

severe clinical condition, resembling the well-known neuroleptic

malignant syndrome, characterised by hyperthermia, impaired

consciousness, autonomic dysfunction (e.g. respiratory failure) and elevated serum creatine kinase levels."

I suspect there are similar mechanisms involved in SUDPAR.

Some possible avenues for discussion and research:

- autonomic nervous system dysfunction leading to immune dysregulation which could cause chronic inflammation and increased vulnerability to infection

- direct effects of a-syn pathology on immune cell function

ncbi.nlm.nih.gov/pmc/articl...

- peripheral dopamine and its effects on the Na/K ATPase in lung epithelium

ncbi.nlm.nih.gov/pmc/articl...

- role of serotonergic system (it's implicated in sudden death in PD and MSA as well as SIDS, and is involved in ventilatory response generally)

pubmed.ncbi.nlm.nih.gov/194...

beehive23 profile image
beehive23 in reply to Rhyothemis

Very Nice! Ta for that! cheers!

more speculative - just want to add this in case I forget about it - the role of paraoxonase in oxygen sensing in the periphery. There is evidence for AMPK's role in peripheral oxygen sensing with feedback to ventilatory control in brainstem; it might act through the AMPK/PON1 signalling axis (the latter statement is just speculation).

PON1 gene variants are associated with PD, and it is thought that these variants increase susceptibility to damage from environmental toxicants such as organophosphate pesticides which could initiate the disease process. I don't know if PON1 has a role in the ongoing PD disease process. I'm also very interested in PON2 as it is expressed much more highly in females than males; it is localized in mitochondria and is probably not directly involved in response to pesticide exposure; it interacts with coenzyme Q10.

There was a medical hypothesis-type article that suggests flavonoids for prevention of SUDPAR; I like the idea but have to admit that not much evidence was presented:

kenkyugroup.org/article/9/1...

High flavonoid foods like blueberries and acai unpregulate PON1 expression. Acai also increases erythropoietin production - perhaps by acting as a hormetic effector, mimicking hypoxia:

ncbi.nlm.nih.gov/pmc/articl...

An interesting sort of related factoid is that cetaceans (whales and dolphins) have evolved to lack PON1 activity. It may have something to do with adaptations diving; type of dietary fat intake is another possibility:

youtu.be/S36zqLDrecI?t=200

{ sorry I'm blathering on about this stuff; it keeps my mind off of other things... }

beehive23 profile image
beehive23 in reply to Rhyothemis

thanks! ive been more or less aware of this data or lack thereof but i eat the rainbow because of the role of flavonoids , like berries. Im pretty concerned of SUDPAR. Thank you!

Anxiety causes breathing difficulties too and I sense this is making you very anxious.

Your problems may be caused by Parkinson’s and medication but some problems in breathing might be due to myofascial constriction. Read my early posts on myofascial stretching. If you can expand your chest using these stretching techniques it will help increase your lung capacity so you can breathe more deeply which might help if your lungs are deteriorating.

I start each morning by stretching my chest to get deeper breaths. Put a pillow under the top of your back just below the shoulder so your head is not on it but pulled down over it and stretch your arms out on each side. Breathe in deeply and out and feel the stretch in your shoulders and upper back.

Every time you think of it during the day when you are standing lean over from the waist to stretch your other side.

Try and stand and reach towards your toes. Imagine your back and chest is bound up with lots of little rubber bands and you are trying to break them.

How fascia affects your body

posturefit.nz/fascia-and-my...

healthunlocked.com/parkinso...

This also helps your flow of lymphatic and glymphatic fluids which remove waste from your brain.

beehive23 profile image
beehive23 in reply to LAJ12345

All true and good info but i am deferring to the Neurosurgical team assessment and reassessment over a period of years...... Cheers!

LAJ12345 profile image
LAJ12345 in reply to beehive23

You can do both safely😊

beehive23 profile image
beehive23 in reply to LAJ12345

Ill try that thank you!

beehive23 profile image
beehive23 in reply to LAJ12345

im trying what you suggested....Ta for that...

LAJ12345 profile image
LAJ12345 in reply to beehive23

Let me know how it goes.

I’m not sure if this regency is on any of your earlier posts already but this from outthinking Parkinson’s is interesting on breathing disorders

outthinkingparkinsons.com/a...

yes! thank you ...i am familiar! i like the way they address loneliness and how it predicts ...pd stuff....

Anyone has breathing problems

beehive23 profile image
beehive23 in reply to Leslim

yep...chest wall muscles get rigid then diaphragms.....down to 43% vital capacity....pd induced stage 3 COPD and pd induced chronic respiratory failure. Im 53.

Anyone suffering bad periods with pd ?

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