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Cure Parkinson's

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Farnesol

JayPwP profile image
39 Replies

healthing.ca/diseases-and-c...

A compound that occurs naturally in herbs, berries and other fruits was able to prevent — and even reverse — the effects of Parkinson’s disease in early tests on mice, a new study has found.

The research, published in the journal Science Translational Medicine, found that farnesol, a compound commonly used to flavour food and make perfume, prevents the death of dopamine-producing neurons by deactivating PARIS, a different protein that fosters the gradual progression of Parkinson’s. Without the protective effect of these neurons, movement and cognition becomes impaired, giving rise to the tremor, muscle rigidity, confusion and dementia associated with the progressive disorder

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JayPwP
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CPT_Helen profile image
CPT_HelenPartner

The challenge we have is we have no idea of safety in humans yet - so this is the essential next step.

JayPwP profile image
JayPwP in reply to CPT_Helen

I agree Helen, but if it is present in fruits, then safety concerns may be minimal... in my opinion, I am not a doctor, just a person with PD

in reply to CPT_Helen

What can we, PWP do to encourage and support Cure Parkinson’s to pursue farnesol as a potential Parkinson’s treatment? It is my intention to make the same inquiry with John Hopkins.

healthabc profile image
healthabc

I will be adding a cup of soothing lemongrass tea to my regimen...

Baron1 profile image
Baron1

Good Afternoon JayPwP, it would be great if someone from the "Health Unlocked" community could find a palatable source that is of significant quantity that would be of some benefit in trying. I mean no extreme excessive quantity, but some meaningful amount. As others that have replied have mentioned, if it is in fruit, berries, herbs, etc, surely there must be somewhere or some way of finding out how much is in each fruit or herb. What other medical uses has it been tried for? If there has been others, then there must be a certain amount that would trigger some benefit. I am still researching to find somewhere it has been used in certain distinguishing quantities to ascertain how much is safe and what product has the most amount. Thanks for the posting this article.

JayPwP profile image
JayPwP in reply to Baron1

Farnesol is a sesquiterpene alcohol that exists widely in fruits such as peaches, vegetables such as tomatoes and corn, herbs such as lemon grass and chamomile, and in the essential oils of ambrette seeds and citronella

hindawi.com/journals/ecam/2...

However the human dosage, efficacy and safety must be established first.

Baron1 profile image
Baron1 in reply to JayPwP

faithful-to-nature.co.za/in...

JayPwP profile image
JayPwP in reply to Baron1

Is this edible?

JayPwP profile image
JayPwP

pubmed.ncbi.nlm.nih.gov/343...

Abstract here

Baron1 profile image
Baron1

I have sent an e-mail to this company, requesting more information and I am waiting for a reply. I will post the answer about whether this is for human consumption or whether they know of another Farnesol product that is for consumption.

JayPwP profile image
JayPwP in reply to Baron1

Thanks

in reply to Baron1

Hi there, any response from this company? Any other insights? Thank you for having inquired!

Baron1 profile image
Baron1 in reply to

Good Morning, one of the representatives of the company replied back and stated that their products are not for human consumption.

JayPwP profile image
JayPwP in reply to Baron1

Thanks

JayPwP profile image
JayPwP

In a 1994 report released by five top cigarette companies, farnesol was listed as one of 599 additives to cigarettes.

Can this be contributory to cigarette induced protection against PD?

in reply to JayPwP

Wow! Jay! That is truly a discovery!

JayPwP profile image
JayPwP in reply to

😆😆😆

Bolt_Upright profile image
Bolt_Upright

alibaba.com/product-detail/...

I guess this means it is edible:

Usage:

Daily Flavor, Food Flavor, Industrial Flavor

Bolt_Upright profile image
Bolt_Upright in reply to Bolt_Upright

This one looks better. Costs more too. alibaba.com/product-detail/...

Taima organic pure Farnesol

in reply to Bolt_Upright

What about topical skin application? I know it’s common to infuse skin cream with essential oils ?

Bolt_Upright profile image
Bolt_Upright in reply to

Are you thinking topical application as a means of delivery? It says it is a food flavoring. I'm thinking an eye dropper full in my smoothie.

in reply to Bolt_Upright

Good idea! You are so solutions oriented. You are so inquisitive and motivated!

Bolt_Upright profile image
Bolt_Upright in reply to

Before my neurologist told me I was doomed on April 2nd I was feeling as good as I had ever felt in my life. Good to know my brain is still working (but today I forgot what kind of car I own. Just the name of it. It's an Element. Only had is 17 years).

Thanks, Bolt.

Getz profile image
Getz in reply to Bolt_Upright

If you buy some from this supplier could you please let us know. Tamia seems a bit more professional, I am very very interested.

Bolt_Upright profile image
Bolt_Upright in reply to Getz

Tamia?

Getz profile image
Getz in reply to Bolt_Upright

Taima. Sorry.

Bolt_Upright profile image
Bolt_Upright in reply to Getz

I'm sorry. What is Taima? Is that a person?

Getz profile image
Getz in reply to Bolt_Upright

This one looks better. Costs more too. alibaba.com/product-detail/...

Taima organic pure Farnesol

This was your post and I simply spelt it incorrectly.. I was hoping you would order some and give some feedback,

in reply to Getz

I want to make sure I’m looking at the right thing. A link if you don’t mind?

Bolt_Upright profile image
Bolt_Upright in reply to

alibaba.com/product-detail/...

Getz profile image
Getz in reply to

Go 11 posts up for the original by Bolt_Upright.

Bolt_Upright profile image
Bolt_Upright in reply to Getz

Thanks! I'm an idiot.

Getz profile image
Getz in reply to Bolt_Upright

Not at all. You have located and shared some very good information.

Bolt_Upright profile image
Bolt_Upright

Here is a nice presentation on Farnesol for MS. It's a graduate student, but good info: dc.ewu.edu/srcw_2020_oral_p...

Getz profile image
Getz in reply to Bolt_Upright

To quote a conclusion in this report"We demonstrate that there is a correlation between EAE severity and FOL oral treatment. Understanding the neuroprotective effects of FOL may provide insight into novel therapeutic approaches for MS."

Sounds pretty good for taking it orally.

Bolt_Upright profile image
Bolt_Upright

Good Farnesol article. More detailed than most.

Chemical in essential oils may treat Parkinson's disease

medicalnewstoday.com/articl...

bassofspades profile image
bassofspades

Mice, huh? Hmmmm...?

Discogs_discogs profile image
Discogs_discogs

If you order this from Amazon, I am not sure that they will ship it on ice or have kept it frozen. I was reading somewhere else that Farnesol must be kept frozen and shipped on ice. Also, on another website, here are the warnings about Farnesol which I have cut and pasted below. It is not clear to me that it is safe to ingest:_______________

FARNESOL

$15 - $390

Product name:FARNESOL

CAS:4602-84-0

MF: C15H26O

MW:222.37

EINECS:225-004-1

MDL Number:MFCD00002918

Synonyms:6,10-Dodecatrien-1-ol,3,7,11-trimethyl-2 ;farnesol,mixtureofisomers ;Farnesyl alcohol;10-dodecatrien-1-ol,3,7,11-trimethyl-6 ;2,6,10-trimethyl-2,6,10-dodecatrien-12-ol[qr] ;3,7,11-trimethyl-2,6,10-dodecatrien-1-ol[qr] ;3,7,11-Trimethyl-2,6,10-dodecatrienol;farnesylalcohol

Price

Brand:Sigma-Aldrich

Product number:F203

Product nameFarnesol

Purity:95%

Packaging:25g

Price:$44.6

Updated:2021/3/22 19:32:49

Buy:Buy

Brand:Sigma-Aldrich

Product number:F203

Product nameFarnesol

Purity:95%

Packaging:100g

Price:$138

Updated:2021/3/22 19:32:48

Buy:Buy

Brand:TCI Chemical

Product number:T0608

Product nameFarnesol (mixture of isomers)

Purity:

Packaging:5g

Price:$18

Updated:2021/3/22 18:33:13

Buy:Buy

Brand:TCI Chemical

Product number:T0608

Product nameFarnesol (mixture of isomers)

Purity:

Packaging:25g

Price:$46

Updated:2021/3/22 18:33:12

Buy:Buy

Brand:TCI Chemical

Product number:T0608

Product nameFarnesol (mixture of isomers)

Purity:

Packaging:100g

Price:$123

Updated:2021/3/22 18:33:11

Buy:Buy

12 3 4

Properties

Melting point:25°C

Boiling point:149 °C4 mm Hg(lit.)

Density 0.886 g/mL at 20 °C(lit.)

FEMA 2478 | FARNESOL

refractive index n20/D 1.490(lit.)

Flash point:205 °F

storage temp. 2-8°C

pka14.69±0.10(Predicted)

form Liquid

color Clear colorless to faint yellow

Water Solubility Not miscible or difficult to mix in water.

Sensitive Light Sensitive

Merck 14,3937

JECFA Number1230

BRN 1763926

Stability:Stable. Combustible. Incompatible with strong oxidizing agents.

CAS DataBase Reference4602-84-0(CAS DataBase Reference)

NIST Chemistry Reference2,6,10-Dodecatrien-1-ol, 3,7,11-trimethyl-(4602-84-0)

EPA Substance Registry SystemFarnesol (4602-84-0)

Safety Information

Symbol(GHS)

Signal wordWarning

Hazard statements

H315:Causes skin irritation

H317:May cause an allergic skin reaction

H319:Causes serious eye irritation

H411:Toxic to aquatic life with long lasting effects

Precautionary statements

P273:Avoid release to the environment.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P391:Collect spillage. Hazardous to the aquatic environment

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.

P337+P313:IF eye irritation persists: Get medical advice/attention.

P501:Dispose of contents/container to..…

Description

It can be used to induce apoptosis in cell cultures. It is also used as an antimicrobial agent. It is used in perfumes and as a flavoring agent.

Related product price

Tetrahydrolinalool

$20-226

(-)-LINALOOL

$50-1020

FARNESYL ACETATE

$19-200

Suppliers and manufacturers

J & K SCIENTIFIC LTD.

Meryer (Shanghai) Chemical Technology Co., Ltd.

3B Pharmachem (Wuhan) International Co.,Ltd.

Alfa Aesar

TCI (Shanghai) Development Co., Ltd.

Energy Chemical

Nanjing Chemlin Chemical Co., Ltd

Shanghai Hanhong Scientific Co.,Ltd.

BEST-REAGENT

Tianjin heowns Biochemical Technology Co., Ltd.

Discogs_discogs profile image
Discogs_discogs

Farnesol is in blueberries, strawberries, raspberries, peaches, tomatoes, corn and more, but would it require us to eat thousands of these fruits to receive the same amount of farnesol as used in this Johns Hopkins study? I wish I knew.

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