Phosphatidylserine, a substance that occurs naturally in the brain and shows promise in several studies. This supplement may increase levels of brain chemicals involved with memory. DO NOT take phosphatidylserine if you are taking anticoagulants (blood thinners), and use caution when combining it with ginkgo for the same reason.
Our studies have indicated that DHA supplementation promotes phosphatidylserine (PS) accumulation and inhibits neuronal cell death under challenged conditions, supporting a notion that DHA is an important
Phosphatidylserine synthase plays an essential role in glia and affects development, as well as the maintenance of neuronal function 2021 sciencedirect.com/science/a...
• Loss of Pss leads to developmental defects and neurodegeneration
• Loss of Pss causes a mitochondrial defect, elevated ROS, and secondary necrosis
• Pss functions in glia are essential for synaptogenesis and neuronal maintenance
• Glial Pss expression level must be tightly regulated to maintain a healthy nervous system
Might be able to treat the sleep problems with PD: ER Lipid Defects in Neuropeptidergic Neurons Impair Sleep Patterns in Parkinson’s Disease 2018 sciencedirect.com/science/a...
• Parkinson’s disease (PD) models (parkin/pink1 loss) have circadian and sleep defects
• Increased ER-mitochondria contacts cause neuropeptide accumulation in ER in PD models
• Depletion of phosphatidylserine from ER causes sleep pattern phenotypes in PD models
• Phosphatidylserine supplementation rescues circadian and sleep defects of PD models
“It is also important to note that the disordered circadian rhythmicity and sleep patterns are caused by neuronal dysfunction and not neurodegeneration, which implies that it can be corrected, as we show here in flies by the addition of [phosphatidylserine] to the food,”
Was advised to take in AM by functional MD. According to Theraputic Natural Medicines pharmasist DB reported adverse effects:
Orally, phosphatidylserine can cause insomnia. Insomnia is more likely to occur with a higher dose of 600 mg (7121,68844). Headache has also been reported.
Listed Drug interactions as follows:
ANTICHOLINERGIC DRUGS
Interaction Rating = Moderate Be cautious with this combination.
Severity = Moderate • Occurrence = Possible • Level of Evidence = B
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
- Details
Phosphatidylserine is thought to increase acetylcholine levels (2437,8857,8858), which could theoretically interfere with the activity of anticholinergic agents.
CHOLINERGIC DRUGS
Interaction Rating = Moderate Be cautious with this combination.
Severity = Moderate • Occurrence = Possible • Level of Evidence = B
Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
- Details
Phosphatidylserine is thought to increase acetylcholine levels (2437,8857,8858), which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.
I did years ago but noticed no huge difference so I put it aside, but also must mention that I did not take the minimal effective dosage many report around 300mg plus where it gets pricey. It has virtually no major side effects, increases ATP in nerve cells, lowers biomarkers of stress, and helps with memory/cognition.
You need to start responses like this with "I don't have PD, but". Even if nedim is aware that you are not a PWP, there are potentially thousands of lurkers here reading this that aren't.
Thank you Rescuema! As always, I appreciate your sharing your knowledge, the depths of which amazes me and your experience. I know of your many years of caring for a PWP and we are so blessed to have your years of research and wisdom to benefit us.
I've been really upping nootropics recently, actually motivated by you cc! I've also added bacopa (will use it for at least 4 weeks daily) so definitely hazing my Hup A and uridine personal Guinea pig trial, but I do believe nutrients/trophic support all tend to work in concert and there can always be a rate-limiting factor to stall progress. I'm revisiting all these "expired" substances again - past inefficacy could've been B1 brain deficiency and acetylcholine imbalance, so I may actually try adding PS again later at a higher dosage to my stack to see it also makes a difference. 💕
A good choline supply from your diet (up to 2 egg yorks at a meal separated by 5 hrs or more, or 1 egg at a time to maximize absorption to limit TMAO) or Citicoline/Alpha-GPC. Some people need more choline than others for methylation needs or your homocysteine will stay high and cause insulin resistance.
And don't forget B1 (spark to an engine), which if you lack (due to a poor diet, sugar, alcohol, etc) then it's a bottleneck to everything including neurotransmitter synthesis.
For basics, combine with a good methyl B complex, such as Pure Encapsulations B-Complex Plus or other fully active formulations (in case of MTHFR SNPs affecting methylation/homocysteine), don't be deficient in zinc in appropriate proportion with copper (Jarrow's Zinc Balance), Magnesium, D3, Omega3/DHA, and good multivitamins for trace minerals - alternate based on diet.
You did it again, Rescuema! That is helping us, the lay care spouses, determine the right nootropics for our loved ones.
Like you, Uridine and Hup A are on alternate days. In addition, as I mentioned before, hubby is on BodyBio Complex of Phospholipids. He takes this with Uridine and Fish Oil (Metagenics 720), Tuesday, Wednesday and Friday. On Mondays and Thursdays, he takes Hup A without the rest of the nootropics. However, when hubby was diagnosed, FM recommended Ashwagandha, Bacopa, and Gingko. He has been on these for a long time. Makes me wonder now if I should have him stop them and cycle them instead.
After about 3 months of Hup A, depending on what you notice, I wouldn't hesitate to cycle with Ashwagandha and Bacopa, both of which are adaptogens along with cerebral circulator Ginkgo as long as they help. You can also carefully choose to use them all together at lower dosages as many nootropic formulas often do. I've been titrating down still to find the right dosage based on my sleep patterns and how I feel since pushing acetylcholine definitely contributes to insomnia. If your husband doesn't wear FitBit (Charge 5) or other fitness watches, I highly recommend one so that you can monitor various health metrics objectively along with sleep scores.
Although "Newbie" 😀, you have been a tremendous help/asset to this forum. Excellent finds.
Speak with your physician. Who could that be??? I am being sarcastic towards these kinds of remarks. I know of NO MD who has the foggiest about supplements and side effects.
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Make your own Spermidine with buckwheat sprouts (neuroprotective)
Believe the unbelievable
A theoretical way to make mannitol work better
Laurie Mischley on Using High DHA Fish Oil to Reduce Levodopa-Induced Dyskinesia (Updated) 
