Make your own Spermidine with buckwheat sprouts (neuroprotective)

[Reetpetitio]

Here's the how-

eng.healthbiocare.com/anti-...

and here's the why!

neurores.org/index.php/neur...

headline - promotes autophagy and is a brain antioxidant which protects against α-synuclein neurotoxicity

[Bolt_Upright]

I did not think it really was what it sounded like.

What is spermidine?

Since this substance was first discovered in male seminal fluid in 1878, it was given the name spermidine. However, nowadays it is known that this polyamine is present in all living organisms and body cells. This natural substance is not only produced by our cells, but we also absorb it to a large extent through our diet.

Spermidine in food

Spermidine is a secondary plant substance found in a variety of foods – for example, legumes, wheat, mushrooms, cauliflower, aged cheese, or mangoes. Spermidine is formed during the germination process, so sprouts such as germinated wheat, buckwheat sprouts, and soybean sprouts are particularly good sources of it.

[Bolt_Upright in reply to Bolt_Upright]

Looks like Spermidine is another good thing I am getting in my daily broccoli sprouts!

Polyamines in Different Organs of Brassica Crop Plants with or without Clubroot Disease 2015 tandfonline.com/doi/pdf/10....

"broccoli sprouts were rich in putrescine, spermidine and agmatine as shown in the present study. Therefore, the Brassica organs are useful as nutrient-rich vegetables for polyamine intake."

My broccoli sprouting instructions: rbd-pd-protocols.blogspot.c...

[Reetpetitio in reply to Bolt_Upright]

Yes! Just nothing like the quantity that is in buckwheat. You need 100g of buckwheat sprouts a day to get the recommended neuroprotective dose of spermidine - that's already quite a lot.

I like buckwheat and imagine the sprouts would be delicious 🤞🏼 Also love roasted buckwheat tea - hopefully it's in that too

[SilentEchoes in reply to Reetpetitio]

Buckwheat and rhubarb are in the same plant family - high in oxalate. Be careful how much you consume.

I wonder if spermidine supplement has oxalate. I know curcumin does. I found a brand that does not contain oxalate, it's spendy.

SE

[Reetpetitio in reply to SilentEchoes]

Aaarghh. I really appreciate you telling me that. And I have a part of me that is overwhelmed with another dietary thing to pay attention to! But googling oxalates I can see it really is relevant.

[Gymsack]

what does this mean?

"The mechanism of polyamine aggregate formation for α-synuclein has been studied in detail. It has been established that spermine, spermidine and putrescine drastically accelerate the aggregation and fibrillation of α-synuclein [9] by binding to the N-terminal region of the amyloid beta peptide (binding site of metal ions such as Cu2+ and Zn2+). Obviously, polyamines can compete with metal ions for binding to proteins. Accordingly, a hypothesis has been proposed that decreasing polyamine content in PD can contribute to correction of neurodegenerative processes in the brain [9]. The authors conclude that lower polyamine levels can be viewed as a potential therapeutic goal for the treatment of PD and that lower values can be reached by administration of compounds that either enhance the catalytic activity of the polyamine in question or inhibit polyamine synthesis. However, these conclusions do not show promise [9].

Another molecular mechanism by which polyamines affect the structure of brain proteins is their interaction with glutamyl residues of proteins, such as neuronal tubulin and transglutaminase, which form an irreversible post-translational modification of γ-glutamylamine [82]. Transglutaminase activation boosts formation of protein aggregates with polyamines [82]. On the other hand, increased polyamine content leads to cytotoxic effects by promoting formation of toxic metabolites, including aldehydes and H2O2. This begs the question, whether polyamine-related protein aggregation is in fact neuroprotective or neurotoxic [28].

[SilentEchoes in reply to Gymsack]

Poly = many

Amine = ammonia derivative

ase = enzyme

Numerous empirical studies support the claim that spermidine, the most abundant polyamine in mammals, acts as an elixir of life.

Previous studies have demonstrated that polyamine concentrations tend to decrease with age. Polyamines within mammalian cells are irreplaceable, as the depletion of polyamines will completely halt cell growth and proliferation.

Polyamines, which are small polycationic compounds with a positive charge, are found in all types of living cells, including those of mammals, plants, and prokaryotes. It is well known that there are three primary types of polyamines present in mammalian cells: putrescine (Put), spermidine (Spd), and spermine (Spm). The discovery of polyamines, specifically spermidine and spermine, dates back to 1678 when Antonie van Leeuwenhoek made the initial observation. Although all eukaryotic cells are capable of synthesizing the three major polyamines, polyamines can also be obtained through diet and other alternative sources, including *intestinal bacteria*.

Consequently, the regulation of polyamine concentration and activity is of the utmost importance and is achieved via a complex network of pathways. The regulation of intracellular polyamine levels and activities is governed by pathways involved in polyamine synthesis, degradation, and transport, which have been extensively studied in bacteria, yeast, and higher organisms.

There is good and bad in everything - all things in moderation

SE

Overview of Polyamines as Nutrients for Human Healthy Long Life and Effect of Increased Polyamine Intake on DNA Methylation ncbi.nlm.nih.gov/pmc/articl...

Polyamines: their significance for maintaining health and contributing to diseases biosignaling.biomedcentral....

[Gymsack in reply to SilentEchoes]

You are correct

The papers conclusion does not say that more Polyamines ingested would be beneficial. It says that more study should be done to confirm it's role in PD because it could be a cause or detrimental to the treatment or have a positive roll , they dont know.

But as my grandfather would have said

" Hold them Newt, they are heading for the Buck Wheat "

[JayPwP]

Also have a look at this

healthunlocked.com/cure-par...