Urolithin A (UA)

[pvw2]

Anyone familiar with Urolithin A . See article:

Urolithin A protects dopaminergic neurons in experimental models of Parkinson's disease by promoting mitochondrial biogenesis through the SIRT1/PGC-1α signaling pathway

pubs.rsc.org/en/content/art...!

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

pubmed.ncbi.nlm.nih.gov/274...

[park_bear]

The the nut and berry diet:

"urolithin A (UA), a gut metabolite produced from ellagic acid-containing foods such as pomegranates, berries and walnuts,"

[Raphaekg]

Just gotta say it: tons of stuff protects dopaminergic neurons in nonhuman models...but it fails to work in the human brain. Our brains are unique. We are the Only species who have vulnerable dopaminergic neurons with neuromelanin.

[park_bear in reply to Raphaekg]

The other part of the problem is most studies pretreat with the test substance and then apply the toxicant. In the case of actual Parkinson's the toxic exposure is long gone and the damage already done.

[Zardoz]

sciencedaily.com/releases/2...

This link describes a "small cohort of people over age 65" who benefited from a 1000mg dose of urolithin A over a four month period.